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Sci Rep ; 11(1): 757, 2021 01 12.
Artículo en Inglés | MEDLINE | ID: mdl-33436814

RESUMEN

Receiving timely and appropriate treatment is crucial for better health outcomes, and research on the contribution of specific variables is essential. In the mental health domain, an important research variable is the date of psychosis symptom onset, as longer delays in treatment are associated with worse intervention outcomes. The growing adoption of electronic health records (EHRs) within mental health services provides an invaluable opportunity to study this problem at scale retrospectively. However, disease onset information is often only available in open text fields, requiring natural language processing (NLP) techniques for automated analyses. Since this variable can be documented at different points during a patient's care, NLP methods that model clinical and temporal associations are needed. We address the identification of psychosis onset by: 1) manually annotating a corpus of mental health EHRs with disease onset mentions, 2) modelling the underlying NLP problem as a paragraph classification approach, and 3) combining multiple onset paragraphs at the patient level to generate a ranked list of likely disease onset dates. For 22/31 test patients (71%) the correct onset date was found among the top-3 NLP predictions. The proposed approach was also applied at scale, allowing an onset date to be estimated for 2483 patients.


Asunto(s)
Registros Electrónicos de Salud/estadística & datos numéricos , Servicios de Salud Mental/estadística & datos numéricos , Procesamiento de Lenguaje Natural , Trastornos Psicóticos/diagnóstico , Evaluación de Síntomas/métodos , Humanos , Salud Mental , Estudios Retrospectivos
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