Marginal Bone Loss in Posterior Implants Placed at Different Levels and Different Prosthetic Designs: A Retrospective Study."

Various factors influence marginal bone loss following implant placement. This study explored the association between marginal bone loss and posterior implants positioned at different bone levels. Computer records and radiographs of patients with at least two adjacent implants were retrieved. Cases were categorized into non-splinted prosthesis and splinted prosthesis groups. Radiographic measurements were conducted at the time of abutment placement (T0), 1-3 years follow-up (T1), and the last visit (T2), measuring the vertical distance between adjacent implants. Multilevel linear regression models using generalized estimating equations were employed, with a significance level set at 5% (α=0.05). Fifty-six patient records were included, comprising 120 implants: 84 non-splinted (70%) and 36 splinted (30%). In the non-splinted group, marginal bone loss progression significantly depended on crestal height differences. For the mesial sides of posterior implants, marginal bone loss measured 1.0 ± 0.6 mm from T0 to T1, 2.4 ± 1.1 mm from T1 to T2, and 3.4 ± 1.2 mm from T0 to T2. Similarly, the distal sides of the most anteriorly placed implant exhibited marginal bone loss of 1.0 ± 0.7 mm from T0 to T1, 2.4 ± 1.0 mm from T1 to T2, and 3.5 ± 1.2 mm from T0 to T2. Non-splinted implants demonstrated a higher progression of marginal bone loss. This study suggests that non-splinted implants may lead to a more pronounced progression of marginal bone loss, particularly concerning crestal height differences, underscoring the need for further research.

Provenance, diagenesis, and depositional environment of Miocene Kamlial Formation, Azad Jammu and Kashmir, Sub Himalayas, Pakistan: Evidences from field observations and petrography.

Petrographical characterization and field observations were caried out to evaluate Kamlial Formation in Bagh district, Azad Jammu and Kashmir. Based on detailed petrography, the lithic arenite consisted of quartz (20-25%), feldspar (7-11%), rock fragments (20-37%), cementing materials (11-21%), and accessory minerals. Grains are mostly angular to subrounded and poorly to moderately sorted. The analysis revealed that the lithic arenite is mineralogically immature; also, the current activity during the time of deposition was low. Polycrystalline quartz indicates that the sandstone was derived from metamorphic source, while monocrystalline quartz indicates a granitic origin. Quartz having an angular shape suggests the source rock was near the depositional site, while quartz having a rounded shape represents long transportation. The presence of feldspar in the lithic arenite suggests the rocks were deposited at high relief or cold temperatures. Primary porosity in sandstone was reduced by calcite cements around the grain, while secondary porosity was developed by fracturing of quartz and feldspar. Tectonic uplift in the study area was demonstrated by fractured quartz and mica in thin sections. Field observations of various sedimentary structures were observed such as load casts, ripple marks, and mud cracks, etc. The presence of conglomerates and load casts in the study area indicates that the Kamlial sandstone was deposited by fluvial and shallow marine environment. Furthermore, the ripple marks indicate that the tidal flat environment controlled the deposition of the sediments.

High-pressure response of vibrational properties of b-AsxP1-x:in situRaman studies.

The structural evolution of black arsenic-phosphorous (b-AsxP1-x) alloys with varying arsenic concentrations was investigated under hydrostatic pressure usingin situRaman spectroscopy. High-pressure experiments were conducted using a diamond anvil cell, which revealed pressure-induced shifts in vibrational modes associated with P-P bonds (A1g,A2g,B2g), As-As bonds (A1g,A2g,B2g), and As-P bonds in b-AsxP1-xalloys. Two distinct pressure regimes were observed. In the first regime (region I), all vibrational modes exhibited a monotonic upshift, indicating phonon hardening due to hydrostatic pressure. In the second regime (region II), As0.4P0.6and As0.6P0.4alloys displayed a linear blueshift (or negligible change in some modes) at a reduced rate, suggesting local structural reorganization with less compression on the bonds. Notably, the alloy with the highest As concentration, As0.8P0.2, exhibited anomalous behavior in the second pressure regime, with a downward shift observed in all As-As and As-P Raman modes (and some P-P modes). Interestingly, the emergence of new peaks corresponding to theEgmode andA1gmode of the gray-As phase was observed in this pressure range, indicating compressive strain-induced structural changes. The anomalous change in region II confirms the formation of a new local structure, characterized by elongation of the P-P, As-As, and As-P bonds along the zigzag direction within the b-AsxP1-xphase, possibly near the grain boundary. Additionally, a gray-As phase undergoes compressive structural changes. This study underscores the significance of pressure in inducing structural transformations and exploring novel phases in two-dimensional materials, including b-AsxP1-xalloys.

N-Phenyl acrylamide-incorporated porous silica-bound graphene oxide sheets with excellent removal capacity for Cr(iii) and Cr(vi) from wastewater.

The sophisticatedly altered Hummer's and sol-gel procedures were applied for the synthesis of graphene oxides and porous silica monolith particles respectively. The Fischer esterification protocol was used for coupling silica monoliths with graphene oxides. A N-phenyl acrylamide-incorporated porous polymer was synthesized at the surface of composites via reversible addition fragmentation chain transfer polymerization. The composition was confirmed by Fourier transform infra-red spectroscopy, FE-SEM, X-ray diffraction, zeta potential (zeta pH), Brunauer-Emmett-Teller (BET/BJH) analysis, and EDAX analysis. The resulting polymer-bound composite efficiently removed Cr(vi) and Cr(iii) from waste water. Adsorption parameters such as contact time, pH effect, temperature, and adsorbent and adsorbate concentration were optimized for the optimal output of the composite. The kinetic and equilibrium models were applied to the adsorption of Cr(vi) and Cr(iii) at the adsorbent surface. The maximum adsorption capacity (qe) of Cr(vi) and Cr(iii) was found to be 298.507 mg g-1 and 401.874 mg g-1, respectively, using the same initial concentration of Cr(vi) and Cr(iii) [10-60 ppm]. The adsorption data of both states of the Cr-metal followed the pseudo 2nd-order kinetic model with regression values of 0.996 ∼ Cr(vi) and 0.999 ∼ Cr(iii) at ambient temperature. Similarly, the adsorption data of Cr(vi) best fit into the Langmuir adsorption isotherm (R2 = 0.972) while that of Cr(iii) followed the Freundlich model (R2 = 0.983).

Synthesis of monolith silica anchored graphene oxide composite with enhanced adsorption capacities for carbofuran and imidacloprid.

Highly efficient adsorbent was prepared for the removal of carbofuran and imidacloprid pesticides from wastewater. The silica monolith anchored graphene oxide composite was synthesized by the modified Fischer esterification protocol. The composite showed improved adsorption capacity for the removal of pesticides from wastewater. Graphene oxide was synthesized using the modified Hummer's method, while the silica monolith was prepared via sol-gel method. The composite was characterized via X-ray diffraction, Fourier transform infra-red, Brunauer Emmett and Teller (BET/BJH) analysis, zeta potential, and FESEM imaging. Different adsorption parameters such as pH, contact time, adsorbate and adsorbent concentration, and temperature were optimized for the adsorption of pesticides. The equilibrium and kinetic models were applied to the adsorption process of the pesticides. Qe of the composite as found to be 342.46 mg g-1 for imidacloprid and 37.15 mg g-1 for carbofuran. The adsorption process followed the pseudo 2nd order kinetic model for carbofuran (R2~0.9971) and imidacloprid (R2~0.9967). The Freundlich isotherm best fitted to the adsorption data of the pesticides with R2 value of 0.9956 for carbofuran and 0.95 for imidacloprid. The resultant adsorbent/composite material came out with very good results for the removal of pesticides.

Adaptive Subsystem Density Functional Theory.

Subsystem density functional theory (DFT) is emerging as a powerful electronic structure method for large-scale simulations of molecular condensed phases and interfaces. Key to its computational efficiency is the use of approximate nonadditive noninteracting kinetic energy functionals. Unfortunately, currently available nonadditive functionals lead to inaccurate results when the subsystems interact strongly such as when they engage in chemical reactions. This work disrupts the status quo by devising a workflow that extends subsystem DFT's applicability also to strongly interacting subsystems. This is achieved by implementing a fully automated adaptive definition of subsystems which is realized during geometry optimizations or ab initio molecular dynamics simulations. The new method prescribes subsystem merging and splitting events redistributing the resources (both for work and data) in an efficient way making use of modern parallelization strategies and object-oriented programming. We showcase the method with examples probing from moderate-to-strong inter-subsystem interactions, opening the door to using subsystem DFT for modeling chemical reactions in molecular condensed phases with a black box computational tool.

A bioresource catalyst system of alginate-starch-activated carbon microsphere templated Cu nanoparticles: Potentials in nitroarenes hydrogenation and dyes discoloration.

The evolution and development of solid-matrix are considered a backbone for supporting and stabilizing of metal nanoparticles (NPs) and are the soul of the catalytic system. In the current study, the alginate-starch microsphere (Alg-St) was cross-linked using CaCl2 as a cross-linker. In addition, the Alg-St microsphere was blended with different percentages of activated carbon (AC). The microspheres adsorbed Cu+2 was reduced to zero-valent copper NPs through NaBH4 and used as a dip-catalyst. The supported Cu NPs cum NaBH4 system was used as dip-catalyst for the hydrogenation of 4-nitrophenol (4NP), 2-nitroanilline (2NA), and degradation of methylene blue (MB) and Congo red (CR) dyes. Among the different kinetics models, the experimental data were well-fitted in the zero-order kinetic model. Moreover pH, and recyclability were studied for 4NP, where the best activity was achieved at pH 7.0 for 4NP. No leaching was observed after 3rd cycle in the catalyst.

Insight the process of hydrazine gas adsorption on layered WS2: a first principle study.

The process of hydrazine gas adsorption on layered WS2 has been systematically studied from first principle calculations. Our results demonstrate that this adsorption process is exothermic, and hydrazine molecules are physically adsorbed. The layer-dependent adsorption energy and interlayer separation induced by van der Waals interaction exerted by hydrazine molecules lead to the difficulty in desorbing hydrazine molecules from layered WS2 as the number of layers increases. The most interesting finding is the emergence of localized impurity states below the Fermi level upon the hydrazine adsorption, irrespective of the number of WS2 layers, resulting in a significant effect on the band structures and subsequently changing its electrical conductivity. Furthermore, a layer-dependent small charge transfer occurs between hydrazine and layered WS2, leading to a charge redistribution and considerable polarization in the adsorbed systems. The existence of defects and the humidity, on the other hand, influences the sensitivity of layered WS2 to the hydrazine adsorption. Obtained results show that a perfectly layered WS2 might be a promising candidate as an efficient nanosensor to detect such toxic gas in dry environment.

Hexane soluble extract of Mallotus philippensis (Lam.) Muell. Arg. root possesses anti-leukaemic activity.

BACKGROUND: Mallotus philippensis (Lam.) Muell. Arg. is a well known medicinal plant of Asia and Australia. Various compounds from different aerial parts of the plant have been reported possessing potent pharmacological, antiviral, antibacterial and cytotoxic activities. We were interested to determine the effects of some root extracts from M. philippensis on human promyelocytic leukemia HL-60 cell proliferation, cell cycle regulators and apoptosis in order to investigate its anti-leukemic potential. RESULTS: Root extract of M. philippensis was initially extracted in organic solvents, hexane, ethyl acetate, and n-butanol. The hexane extract showed highest toxicity against p53-deficient HL-60 cells (IC50 1.5 mg dry roots equivalent/ml medium) after 72 h and interestingly, inhibition of cell proliferation was preceded by the upregulation of the proto-oncogenes Cdc25A and cyclin D1 within 24 h. The hexane extract induced 18% apoptosis after 48 h of treatment. Chemical composition of the hexane extract was analyzed by GC-MS and the 90% fragments were matched with polyphenolic compounds. CONCLUSIONS: The present study confirms that the hexane fraction of M. philippensis root extract possesses anti-leukemic activity in HL-60 cells. The polyphenols were the main compounds of the hexane extract that inhibited proliferation and induced apoptosis.

Bathing and cleaning practices in the camp of Jalozai Pakistan, for internally displaced people, based on Sphere Standards and Indicators.

OBJECTIVES: To evaluate the bathing and cleaning practice, based on Sphere Standards and Indicators, of internally displaced people in the camp of Jalozai, Pakistan. METHODS: This descriptive cross sectional survey was done in displaced population of Jalozai camp Nowshera from February to September 2010. Systematic Random Sampling was done (10% of Phase II Population). Study unit was a single family residing in the camp. A customized structured questionnaire was administered to households and information as recorded by the researchers. Informed consent and confidentiality was maintained while interviewing the household. RESULTS: Although 97% (n=111) families were using soap for bathing but surprisingly none of them were on required Sphere Standards. Similarly 93% (n=107) were using laundry soaps and 49% (n=56) were using washing powder but again were not fulfilling the standards. It was discovered based on our survey that 64% (n=71) displaced people were not using anything for cleaning their children and none were using washable nappies. It was also observed that 99% (n=114) were using toothpastes and other local means for dental hygiene. Less than 10 toothpastes/year were provided to 79% families while 21% (n=24) were not provided at all. CONCLUSION: Our survey population was not on required SPHERE standards for sufficient bathing and laundry soap and they had no access to sufficient amount of toothbrush and toothpaste. Children were not provided with washable nappies or diapers.

Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis.

Berberis lycium Royle (Berberidacea) from Pakistan and its alkaloids berberine and palmatine have been reported to possess beneficial pharmacological properties. In the present study, the anti-neoplastic activities of different B. lycium root extracts and the major constituting alkaloids, berberine and palmatine were investigated in p53-deficient HL-60 cells. The strongest growth inhibitory and pro-apoptotic effects were found in the n-butanol (BuOH) extract followed by the ethyl acetate (EtOAc)-, and the water (H(2)O) extract. The chemical composition of the BuOH extract was analyzed by TLC and quantified by HPLC. 11.1 microg BuOH extract (that was gained from 1mg dried root) contained 2.0 microg berberine and 0.3 microg/ml palmatine. 1.2 microg/ml berberine inhibited cell proliferation significantly, while 0.5 microg/ml palmatine had no effect. Berberine and the BuOH extract caused accumulation of HL-60 cells in S-phase. This was preceded by a strong activation of Chk2, phosphorylation and degradation of Cdc25A, and the subsequent inactivation of Cdc2 (CDK1). Furthermore, berberine and the extract inhibited the expression of the proto-oncogene cyclin D1. Berberine and the BuOH extract induced the acetylation of alpha-tubulin and this correlated with the induction of apoptosis. The data demonstrate that berberine is a potent anti-neoplastic compound that acts via anti-proliferative and pro-apoptotic mechanisms independent of genotoxicity.