RESUMEN
Cytochemical analysis of acid phosphatase was used to evaluate lysosomal membranes stability under oral intake of potassium cyanide by rats over one month in daily doses of 1.30 mg/kg (1/10 LD50) and 0.65 mg/kg (1/20 LD50). The authors demonstrated phase-related dose-dependent changes in the lysosomal state, and the main response feature was associated with functional activation that usually followed the membrane alteration.
Asunto(s)
Modelos Animales de Enfermedad , Lisosomas/efectos de los fármacos , Lisosomas/metabolismo , Cianuro de Potasio/toxicidad , Administración Oral , Animales , Masculino , Intoxicación/sangre , Cianuro de Potasio/administración & dosificación , Cianuro de Potasio/sangre , Ratas , Ratas WistarRESUMEN
The article covers results of long-standing research on clinical peculiarities and course of toxic encephalopathy in distant period of occupational neurointoxications, on main concepts and pathogenetic steps of formation and progress of toxic encephalopathy. Through investigation covered firemen after exposure to complex of toxic chemicals and patients in post-contact period of chronic mercury intoxication. Modelling of chronic inhalation of metallic mercury vapors was performed.