Assessment of patrilineal gene pool of the Iranian Azeris.

The Iranian Azeris are the largest ethno-linguistic minority in Iran who live mainly in the north-west part of the country. Located in the crossroad of ancient human migrations the Iranian Azeris bear the complicated historical influence of the region in their gene pool. Despite the importance of Iranian Azeris in reconstructing the historical event of the Middle-East, their (genetic) origin still remains heavily disputed. In this study we tried to evaluate the rates of genetic contribution of possible source populations (namely, indigenous Iranian, Caucasian, and Central Asian) in the gene pool of modern Iranian Azeris through paternally inherited Y-chromosomal 6 STR markers. The assessment of genetic distances reveals that the Iranian Azeris are mixed population with substantial North Caucasian genetic contribution being genetically much closer to their immediate neighboring ethnic groups. Based on the results of admixture analysis we can conclude that there are significant Caucasian and no visible Central Asian contribution to the gene pool of modern Iranian Azeris.

Patrilocality and recent migrations have little impact on shaping patterns of genetic structure of the Armenian population.

In general, genetic distances between human populations (also within one ethnic group) are larger for the Y chromosome markers than for the mtDNA. It is usually explained by higher rate of female versus male migration due to the cultural practice of patrilocality, when women move to their husbands' residence after marriage. Recently found a reversed picture for the genetic variation in some ethno-territorial groups confirm the strict role of cultural traditions in shaping patterns of populations' genetic structure. To test the role of patrilocality for the genetic structure of the Armenian population, we compared the Y chromosome and the mtDNA haplotype variations among and between geographical groups identified according to paternal (maternal) grandparental place of birth, from one side, and the populations currently living in the same geographical areas, from the other side. The results demonstrate that the Armenian population is regionally more structured for the Y chromosome than for the mtDNA. Additionally, in spite of expressed directivity of migration processes (caused by the phenomenon of patrilocality as well), the patterns of genetic variations for the populations of the same geographic areas remain without any significant changes during the last three generations.

Armenian Y chromosome haplotypes reveal strong regional structure within a single ethno-national group.

Armenia has been little-studied genetically, even though it is situated in an important area with respect to theories of ancient Middle Eastern population expansion and the spread of Indo-European languages. We screened 734 Armenian males for 11 biallelic and 6 microsatellite Y chromosome markers, segregated them according to paternal grandparental region of birth within or close to Armenia, and compared them with data from other population samples. We found significant regional stratification, on a level greater than that found in some comparisons between different ethno-national identities. A diasporan Armenian sub-sample (collected in London) was not sufficient to describe this stratified haplotype distribution adequately, warning against the use of such samples as surrogates for the non-diasporan population in future studies. The haplotype distribution and pattern of genetic distances suggest a high degree of genetic isolation in the mountainous southern and eastern regions, while in the northern, central and western regions there has been greater admixture with populations from neighbouring Middle Eastern countries. Georgia, to the north of Armenia, also appears genetically more distinct, suggesting that in the past Trans-Caucasia may have acted as a genetic barrier. A Bayesian full-likelihood analysis of the Armenian sample yields a mean estimate for the start of population growth of 4.8 thousand years ago (95% credible interval: 2.0-11.1), consistent with the onset of Neolithic farming. The more isolated southern and eastern regions have high frequencies of a microsatellite defined cluster within haplogroup 1 that is centred on a modal haplotype one step removed from the Atlantic Modal Haplotype, the centre of a cluster found at high frequencies in England, Friesland and Atlantic populations, and which may represent a remnant paternal signal of a Paleolithic migration event.