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1.
Artículo en Inglés | MEDLINE | ID: mdl-36881342

RESUMEN

Childhood trauma exposure is prevalent among incarcerated youth and associated with antisocial traits and behavior. It has been proposed as a risk factor for the development of sadistic traits, which has been shown to predict future violence in youth. Using regression analyses, we examined the association between self-report and expert-rated measures of childhood trauma, sadistic traits (i.e., verbal, physical, vicarious sadism), and violence (i.e., homicide and non-homicide violent acts) in 54 incarcerated juveniles. Expert-rated (but not self-report) severity of physical abuse was associated with physical and vicarious sadistic traits. Other trauma types (e.g., emotional or sexual abuse) were not significantly associated with sadistic traits. Physical abuse coupled with vicarious sadistic traits conferred the highest risk of non-homicide violence. The findings support and clarify links between childhood trauma, sadistic traits, and violent behavior in youth, and are distinct from those found in other antisocial profiles.

2.
Transl Psychiatry ; 5: e625, 2015 Aug 25.
Artículo en Inglés | MEDLINE | ID: mdl-26305476

RESUMEN

Psychopathy, characterized by symptoms of emotional detachment, reduced guilt and empathy and a callous disregard for the rights and welfare of others, is a strong risk factor for immoral behavior. Psychopathy is also marked by abnormal attention with downstream consequences on emotional processing. To examine the influence of task demands on moral evaluation in psychopathy, functional magnetic resonance imaging was used to measure neural response and functional connectivity in 88 incarcerated male subjects (28 with Psychopathy Checklist Revised (PCL-R) scores ⩾ 30) while they viewed dynamic visual stimuli depicting interpersonal harm and interpersonal assistance in two contexts, implicit and explicit. During the implicit task, high psychopathy was associated with reduced activity in the dorsolateral prefrontal cortex and caudate when viewing harmful compared with helpful social interactions. Functional connectivity seeded in the right amygdala and right temporoparietal junction revealed decreased coupling with the anterior cingulate cortex (ACC), anterior insula, striatum and ventromedial prefrontal cortex. In the explicit task, higher trait psychopathy predicted reduced signal change in ACC and amygdala, accompanied by decreased functional connectivity to temporal pole, insula and striatum, but increased connectivity with dorsal ACC. Psychopathy did not influence behavioral performance in either task, despite differences in neural activity and functional connectivity. These findings provide the first direct evidence that hemodynamic activity and neural coupling within the salience network are disrupted in psychopathy, and that the effects of psychopathy on moral evaluation are influenced by attentional demands.


Asunto(s)
Mapeo Encefálico , Encéfalo/fisiopatología , Trastornos Mentales/fisiopatología , Principios Morales , Red Nerviosa/fisiopatología , Adulto , Humanos , Imagen por Resonancia Magnética , Masculino , Trastornos Mentales/psicología , Vías Nerviosas/fisiopatología , Prisioneros/psicología , Prisioneros/estadística & datos numéricos
3.
Neuroimage Clin ; 4: 800-7, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24936430

RESUMEN

BACKGROUND: Violence that leads to homicide results in an extreme financial and emotional burden on society. Juveniles who commit homicide are often tried in adult court and typically spend the majority of their lives in prison. Despite the enormous costs associated with homicidal behavior, there have been no serious neuroscientific studies examining youth who commit homicide. METHODS: Here we use neuroimaging and voxel-based morphometry to examine brain gray matter in incarcerated male adolescents who committed homicide (n = 20) compared with incarcerated offenders who did not commit homicide (n = 135). Two additional control groups were used to understand further the nature of gray matter differences: incarcerated offenders who did not commit homicide matched on important demographic and psychometric variables (n = 20) and healthy participants from the community (n = 21). RESULTS: Compared with incarcerated adolescents who did not commit homicide (n = 135), incarcerated homicide offenders had reduced gray matter volumes in the medial and lateral temporal lobes, including the hippocampus and posterior insula. Feature selection and support vector machine learning classified offenders into the homicide and non-homicide groups with 81% overall accuracy. CONCLUSIONS: Our results indicate that brain structural differences may help identify those at the highest risk for committing serious violent offenses.


Asunto(s)
Mapeo Encefálico , Encéfalo/patología , Homicidio/psicología , Adolescente , Estudios de Casos y Controles , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Estudios Retrospectivos , Máquina de Vectores de Soporte , Adulto Joven
4.
Neurology ; 77(24): 2123-7, 2011 Dec 13.
Artículo en Inglés | MEDLINE | ID: mdl-22131543

RESUMEN

OBJECTIVE: We describe the systematic approach to incidental findings (IFs) used at the Mind Research Network (MRN) where all MRI scans receive neuroradiologist interpretation and participants are provided results. METHODS: From 2004 to 2011, 8,545 MRI scans were acquired by 45 researchers. As mandated by MRN's external institutional review board, all structural sequences were evaluated by a clinical neuroradiologist who generated a report that included recommendations for referral if indicated. Investigators received a copy of their participants' reports, which were also mailed to participants unless they specifically declined. To better understand the impact of the radiology review process, a financial analysis was completed in addition to a follow-up phone survey to characterize participant perceptions regarding receiving their MRI scan results. RESULTS: The radiologist identified IFs in 34% of the 4,447 participants. Of those with IFs (n = 1,518), the radiologist recommended urgent or immediate referral for 2.5% and routine referral for 17%. For 80.5%, no referral was recommended. Estimated annual cost for this approach including support for the neuroradiologist, medical director, and ancillary staff is approximately $60,000 or $24/scan. The results of the retrospective phone survey showed that 92% of participants appreciated receiving their MRI report, and the majority stated it increased their likelihood of volunteering for future studies. CONCLUSIONS: Addressing IFs in a cost-effective and consistent manner is possible by adopting a policy that provides neuroradiology interpretation and offers participant assistance with clinical follow-up when necessary. Our experience suggests that an ethical, institution-wide approach to IFs can be implemented with minimal investigator burden.


Asunto(s)
Encéfalo/patología , Hallazgos Incidentales , Neuroimagen/métodos , Comités de Ética en Investigación , Humanos , Imagen por Resonancia Magnética , Proyectos de Investigación , Estudios Retrospectivos
5.
Psychol Med ; 39(2): 325-36, 2009 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-18485263

RESUMEN

BACKGROUND: Prior studies have suggested unique patterns of neural activity associated with compulsive hoarding. However, to date no studies have examined the process of making actual decisions about whether to keep or discard possessions in patients with hoarding symptoms. An increasing body of clinical data and experimental psychopathology research suggests that hoarding is associated with impaired decision making; therefore, it is important to understand the neural underpinnings of decision-making abnormalities in hoarding patients. METHOD: Twelve adult patients diagnosed with compulsive hoarding, 17% of whom also met criteria for obsessive-compulsive disorder (OCD), and 12 matched healthy controls underwent functional magnetic resonance imaging (fMRI) while making decisions about whether or not to discard personal paper items (e.g. junk mail) brought to the laboratory as well as control items that did not belong to them. Items were either saved or destroyed following each decision. RESULTS: When deciding about whether to keep or discard personal possessions, compulsive hoarding participants displayed excessive hemodynamic activity in lateral orbitofrontal cortex and parahippocampal gyrus. Among hoarding participants, decisions to keep personal possessions were associated with greater activity in superior temporal gyrus, middle temporal gyrus, medial frontal gyrus, anterior cingulate cortex, precentral gyrus, and cerebellum than were decisions to discard personal possessions. CONCLUSIONS: These results provide partial support for an emerging model of compulsive hoarding based on complications of the decision-making process. They also suggest that compulsive hoarding may be characterized by focal deficits in the processing of reward and changes in reward contingencies, particularly when these are perceived to be punishing.


Asunto(s)
Cerebelo/metabolismo , Toma de Decisiones , Lóbulo Frontal/metabolismo , Giro del Cíngulo/metabolismo , Trastorno Obsesivo Compulsivo/metabolismo , Trastorno Obsesivo Compulsivo/psicología , Corteza Prefrontal/metabolismo , Lóbulo Temporal/metabolismo , Cerebelo/irrigación sanguínea , Circulación Cerebrovascular , Ambiente , Femenino , Lóbulo Frontal/irrigación sanguínea , Giro del Cíngulo/irrigación sanguínea , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Corteza Prefrontal/irrigación sanguínea , Proyectos de Investigación , Lóbulo Temporal/irrigación sanguínea
6.
Neuroimage ; 42(4): 1560-8, 2008 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-18602482

RESUMEN

We utilized a discrete dynamic Bayesian network (dDBN) approach (Burge, J., Lane, T., Link, H., Qiu, S., Clark, V.P., 2007. Discrete dynamic Bayesian network analysis of fMRI data. Hum Brain Mapp.) to determine differences in brain regions between patients with schizophrenia and healthy controls on a measure of effective connectivity, termed the approximate conditional likelihood score (ACL) (Burge, J., Lane, T., 2005. Learning Class-Discriminative Dynamic Bayesian Networks. Proceedings of the International Conference on Machine Learning, Bonn, Germany, pp. 97-104.). The ACL score represents a class-discriminative measure of effective connectivity by measuring the relative likelihood of the correlation between brain regions in one group versus another. The algorithm is capable of finding non-linear relationships between brain regions because it uses discrete rather than continuous values and attempts to model temporal relationships with a first-order Markov and stationary assumption constraint (Papoulis, A., 1991. Probability, random variables, and stochastic processes. McGraw-Hill, New York.). Since Bayesian networks are overly sensitive to noisy data, we introduced an independent component analysis (ICA) filtering approach that attempted to reduce the noise found in fMRI data by unmixing the raw datasets into a set of independent spatial component maps. Components that represented noise were removed and the remaining components reconstructed into the dimensions of the original fMRI datasets. We applied the dDBN algorithm to a group of 35 patients with schizophrenia and 35 matched healthy controls using an ICA filtered and unfiltered approach. We determined that filtering the data significantly improved the magnitude of the ACL score. Patients showed the greatest ACL scores in several regions, most markedly the cerebellar vermis and hemispheres. Our findings suggest that schizophrenia patients exhibit weaker connectivity than healthy controls in multiple regions, including bilateral temporal, frontal, and cerebellar regions during an auditory paradigm.


Asunto(s)
Mapeo Encefálico/métodos , Encéfalo/fisiopatología , Vías Nerviosas/fisiopatología , Reconocimiento de Normas Patrones Automatizadas/métodos , Esquizofrenia/fisiopatología , Adolescente , Adulto , Inteligencia Artificial , Teorema de Bayes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis de Componente Principal , Adulto Joven
7.
Neuroimage ; 39(3): 1129-41, 2008 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-17996465

RESUMEN

The general linear model (GLM) approach is the most commonly used method in functional magnetic resonance imaging analysis in predicting a particular response. Recently, a novel method of analysis, referred to as inter-participant correlation (IPC), was developed which attempts to determine the level of blood oxygen level-dependent (BOLD) synchrony among subjects. The IPC approach enables detection of changes in inter-participant BOLD synchrony in a manner that does not rely on an explicit model of the hemodynamic activity. In this paper, we extend IPC to the case of two groups and derive an approach for thresholding the resulting maps. We demonstrate our approach by comparing 35 patients with paranoid schizophrenia (DSM-IV sub-type 295.30) to 35 healthy matched controls during an auditory target detection paradigm. Results showed significantly lower inter-participant BOLD synchrony in patients versus healthy controls in areas including bilateral temporal lobes, medial frontal gyrus, anterior cingulate cortex, dorsolateral prefrontal cortex, thalamus, insula, and cerebellum. The IPC approach is straightforward to use and provides a useful complement to traditional GLM techniques. This approach may also be sensitive to underlying, but unpredictable, changes in inter-participant BOLD synchrony between patients and controls.


Asunto(s)
Esquizofrenia Paranoide/patología , Psicología del Esquizofrénico , Localización de Sonidos/fisiología , Estimulación Acústica , Adolescente , Adulto , Mapeo Encefálico , Análisis por Conglomerados , Interpretación Estadística de Datos , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Oxígeno/sangre , Escalas de Valoración Psiquiátrica , Reproducibilidad de los Resultados
8.
Hum Brain Mapp ; 27(1): 47-62, 2006 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-16108017

RESUMEN

The acquisition of both structural MRI (sMRI) and functional MRI (fMRI) data for a given study is a very common practice. However, these data are typically examined in separate analyses, rather than in a combined model. We propose a novel methodology to perform independent component analysis across image modalities, specifically, gray matter images and fMRI activation images as well as a joint histogram visualization technique. Joint independent component analysis (jICA) is used to decompose a matrix with a given row consisting of an fMRI activation image resulting from auditory oddball target stimuli and an sMRI gray matter segmentation image, collected from the same individual. We analyzed data collected on a group of schizophrenia patients and healthy controls using the jICA approach. Spatially independent joint-components are estimated and resulting components were further analyzed only if they showed a significant difference between patients and controls. The main finding was that group differences in bilateral parietal and frontal as well as posterior temporal regions in gray matter were associated with bilateral temporal regions activated by the auditory oddball target stimuli. A finding of less patient gray matter and less hemodynamic activity for target detection in these bilateral anterior temporal lobe regions was consistent with previous work. An unexpected corollary to this finding was that, in the regions showing the largest group differences, gray matter concentrations were larger in patients vs. controls, suggesting that more gray matter may be related to less functional connectivity in the auditory oddball fMRI task.


Asunto(s)
Mapeo Encefálico , Encéfalo/diagnóstico por imagen , Encéfalo/fisiología , Imagen por Resonancia Magnética , Esquizofrenia/fisiopatología , Estimulación Acústica , Algoritmos , Percepción Auditiva/fisiología , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Radiografía
9.
Neuroimage ; 30(2): 544-53, 2006 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-16246587

RESUMEN

Event-related potential (ERP) studies of the brain's response to infrequent, target (oddball) stimuli elicit a sequence of physiological events, the most prominent and well studied being a complex, the P300 (or P3) peaking approximately 300 ms post-stimulus for simple stimuli and slightly later for more complex stimuli. Localization of the neural generators of the human oddball response remains challenging due to the lack of a single imaging technique with good spatial and temporal resolution. Here, we use independent component analyses to fuse ERP and fMRI modalities in order to examine the dynamics of the auditory oddball response with high spatiotemporal resolution across the entire brain. Initial activations in auditory and motor planning regions are followed by auditory association cortex and motor execution regions. The P3 response is associated with brainstem, temporal lobe, and medial frontal activity and finally a late temporal lobe "evaluative" response. We show that fusing imaging modalities with different advantages can provide new information about the brain.


Asunto(s)
Encéfalo/fisiología , Circulación Cerebrovascular/fisiología , Potenciales Relacionados con Evento P300/fisiología , Adulto , Algoritmos , Electroencefalografía , Potenciales Evocados Auditivos/fisiología , Femenino , Hemodinámica/fisiología , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad
10.
Psychol Med ; 35(2): 187-96, 2005 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-15841676

RESUMEN

BACKGROUND: In a recent longitudinal study of first-episode schizophrenia patients, we found that while dysfunction of the right dorsolateral prefrontal cortex (DLPFC), right thalamus, left cerebellum and cingulate gyrus normalized with antipsychotic treatment and significant reduction in symptomatology, the left DLPFC, left thalamus, and right cerebellum remained disturbed. In the present study we investigated whether these abnormalities are also present in clinically stable, relatively well-functioning schizophrenia patients in comparison to control subjects during performance of the N-back working-memory task. METHOD: Twelve schizophrenia and 12 control subjects completed the study. The functional images collected during scanning were analyzed using a random-effects model in a restricted set of six regions of interest (ROIs). In addition, the exploratory search in the entire brain volume was performed. RESULTS: The ROI analyses revealed relative underactivation in the region of the left DLPFC and the right cerebellum, as well as overactivation in the left cerebellum. The exploratory whole-brain search exposed additional overactivation in the medial frontal, anterior cingulate, and left parietal cortices. CONCLUSIONS: The present study provides evidence of significant underactivations in stable schizophrenia patients in regions that we have previously observed to be dysfunctional in acutely psychotic and partially remitted patients, together with extensive overactivations in several regions that potentially reflect some compensatory mechanism or increased effort on the working-memory task.


Asunto(s)
Cerebelo/patología , Cerebelo/fisiología , Memoria , Corteza Prefrontal/patología , Corteza Prefrontal/fisiología , Esquizofrenia/fisiopatología , Psicología del Esquizofrénico , Adulto , Antipsicóticos/farmacología , Antipsicóticos/uso terapéutico , Estudios de Casos y Controles , Cerebelo/efectos de los fármacos , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Corteza Prefrontal/efectos de los fármacos
11.
Neuroimage ; 25(2): 527-38, 2005 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-15784432

RESUMEN

Independent component analysis (ICA) is a data-driven approach utilizing high-order statistical moments to find maximally independent sources that has found fruitful application in functional magnetic resonance imaging (fMRI). Being a blind source separation technique, ICA does not require any explicit constraints upon the fMRI time courses. However, for some fMRI data analysis applications, such as for the analysis of an event-related paradigm, it would be useful to flexibly incorporate paradigm information into the ICA analysis. In this paper, we present an approach for constrained or semi-blind ICA (sbICA) analysis of event-related fMRI data by imposing regularization on certain estimated time courses using the paradigm information. We demonstrate the performance of our approach using both simulations and fMRI data from a three-stimulus auditory oddball paradigm. Simulation results suggest that (1) a regression approach slightly outperforms ICA when prior information is accurate and ICA outperforms the general linear model (GLM)-based approach when prior information is not completely accurate, (2) prior information improves the robustness of ICA in the presence of noise, and (3) ICA analysis using prior information with temporal constraints can outperform a regression approach when the prior information is not completely accurate. Using fMRI data, we compare a regression-based conjunction analysis of target and novel stimuli, both of which elicit an orienting response, to an sbICA approach utilizing both the target and novel stimuli to constrain the ICA time courses. Results show similar positive associations for both GLM and sbICA, but sbICA detects additional negative associates consistent with regions implicated in a default mode of brain activity. This suggests that task-related default mode decreases have a more "complex" signal that benefits from a flexible modeling approach. Compared with a traditional GLM approach, the sbICA approach provides a flexible way to analyze fMRI data that reduces the assumptions placed upon the hemodynamic response of the brain. The advantages and limitations of our technique are discussed in detail in the manuscript to provide guidelines to the reader for developing useful applications. The use of prior time course information in a spatial ICA analysis, which combines elements of both a regression approach and a blind ICA approach, may prove to be a useful tool for fMRI analysis.


Asunto(s)
Encéfalo/fisiología , Imagen por Resonancia Magnética , Análisis de Componente Principal/métodos , Percepción Auditiva , Humanos , Tiempo
12.
Br J Psychiatry ; 185: 205-14, 2004 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-15339824

RESUMEN

BACKGROUND: A number of functional brain abnormalities have been reported in schizophrenia, but it remains to be determined which of them represent trait and state markers of the illness. AIMS: To delineate regional brain dysfunctions that remain stable and those that fluctuate during the course of schizophrenia. METHOD: A cohort of patients with first-episode schizophrenia and a matched group of control participants underwent functional magnetic resonance imaging on two occasions 6-8 weeks apart during performance of a working memory task. The patients' disease was in partial remission at the second scan. RESULTS: Relative to control participants, the function of the left dorsolateral prefrontal cortex, left thalamus and right cerebellum remained disturbed in the people with schizophrenia, whereas the dysfunction of the right dorsolateral prefrontal cortex, right thalamus, left cerebellum and cingulate gyrus normalised, with significant reduction in symptoms. CONCLUSIONS: These results suggest that dysfunction of the left fronto-thalamo-cerebellar circuitry is a relatively stable characteristic of schizophrenia, whereas disturbance of the right circuitry and cingulate gyrusis predominantly a state-related phenomenon.


Asunto(s)
Encefalopatías/fisiopatología , Encéfalo/fisiopatología , Esquizofrenia/fisiopatología , Adulto , Encéfalo/patología , Encefalopatías/patología , Cerebelo/patología , Cerebelo/fisiopatología , Estudios de Cohortes , Femenino , Giro del Cíngulo/patología , Giro del Cíngulo/fisiopatología , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Memoria a Corto Plazo/fisiología , Pruebas Neuropsicológicas , Corteza Prefrontal/patología , Corteza Prefrontal/fisiopatología , Esquizofrenia/patología , Tálamo/patología , Tálamo/fisiopatología
13.
Neuroimage ; 22(1): 252-7, 2004 May.
Artículo en Inglés | MEDLINE | ID: mdl-15110015

RESUMEN

Functional magnetic resonance imaging (fMRI) data are often analyzed using the general linear model employing a hypothesized neural model convolved with a hemodynamic response function. Mismatches between this hemodynamic model and the data can be induced by spatially varying delays or slice-timing differences. It is common practice to desensitize the analysis to such delays by incorporation of the hemodynamic model plus its temporal derivative. The rationale often used is that additional variance will be captured and regressed out from the data. Though this is true, it ignores the potential for amplitude bias induced by small model mismatches due to, for example, variable hemodynamic delays and is not helpful for "random effects" analyses which typically do not account for the first level variance at all. Amplitude bias is due to the use of only the nonderivative portion of the model in the final test for significant amplitudes. We propose instead testing an amplitude value that is a function of both the nonderivative and the derivative terms of the model. Using simulations, we show that the proposed amplitude test does not suffer from delay-induced bias and that a model incorporating temporal derivatives is a more natural test for amplitude differences. The proposed test is applied in a random-effects analysis of 100 subjects. It reveals increased amplitudes in areas consistent with the task, with the largest increases in regions with greater hemodynamic delays.


Asunto(s)
Hemodinámica/fisiología , Imagen por Resonancia Magnética/estadística & datos numéricos , Estimulación Acústica , Adolescente , Adulto , Algoritmos , Simulación por Computador , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Modelos Lineales , Masculino , Persona de Mediana Edad , Modelos Neurológicos , Estimulación Luminosa
14.
Neuroimage ; 19(3): 1085-94, 2003 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-12880834

RESUMEN

Cocaine abusers demonstrate faulty decision-making as manifested by their inability to discontinue self-destructive drug-seeking behaviors. The orbitofrontal cortex (OFC) plays an important role in decision-making. In this preliminary study we tested whether 25-day-abstinent cocaine abusers show alterations in normalized cerebral blood flow (rCBF) in the OFC using PET with (15)O during the Iowa Gambling Task (a decision-making task). This task measures the ability to weigh short-term rewards against long-term losses. A control task matched the sensorimotor aspects of the task but did not require decision-making. Cocaine abusers (N = 13) showed greater activation during performance of the Iowa Gambling Task in the right OFC and less activation in the right dorsolateral prefrontal cortex (DLPFC) and left medial prefrontal cortex (MPFC) compared to a control group (N = 13). Better Iowa Gambling Task performance was associated with greater activation in the right OFC in both groups. Also, the amount of cocaine used (grams/week) prior to the 25 days of enforced abstinence was negatively correlated with activation in the left OFC. Greater activation in the OFC in cocaine abusers compared to a control group may reflect differences in the anticipation of reward while less activation in the DLPFC and MPFC may reflect differences in planning and working memory. These findings suggest that cocaine abusers show persistent functional abnormalities in prefrontal neural networks involved in decision-making and these effects are related to cocaine abuse. Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence.


Asunto(s)
Trastornos Relacionados con Cocaína/fisiopatología , Toma de Decisiones/fisiología , Lóbulo Frontal/fisiopatología , Adulto , Circulación Cerebrovascular , Trastornos Relacionados con Cocaína/diagnóstico por imagen , Femenino , Lóbulo Frontal/irrigación sanguínea , Lóbulo Frontal/diagnóstico por imagen , Juego de Azar/psicología , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Corteza Prefrontal/irrigación sanguínea , Corteza Prefrontal/diagnóstico por imagen , Corteza Prefrontal/fisiopatología , Desempeño Psicomotor/fisiología , Tomografía Computarizada de Emisión
15.
Biol Psychiatry ; 50(9): 677-84, 2001 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-11704074

RESUMEN

BACKGROUND: Psychopathy is a complex personality disorder of unknown etiology. Central to the disorder are anomalies or difficulties in affective processing. METHODS: Functional magnetic resonance imaging was used to elucidate the neurobiological correlates of these anomalies in criminal psychopaths during performance of an affective memory task. RESULTS: Compared with criminal nonpsychopaths and noncriminal control participants, criminal psychopaths showed significantly less affect-related activity in the amygdala/hippocampal formation, parahippocampal gyrus, ventral striatum, and in the anterior and posterior cingulate gyri. Psychopathic criminals also showed evidence of overactivation in the bilateral fronto-temporal cortex for processing affective stimuli. CONCLUSIONS: These data suggest that the affective abnormalities so often observed in psychopathic offenders may be linked to deficient or weakened input from limbic structures.


Asunto(s)
Afecto , Trastorno de Personalidad Antisocial/fisiopatología , Crimen , Sistema Límbico/anomalías , Sistema Límbico/fisiopatología , Imagen por Resonancia Magnética , Adulto , Amígdala del Cerebelo/anatomía & histología , Amígdala del Cerebelo/fisiopatología , Lóbulo Frontal/anatomía & histología , Giro del Cíngulo/anatomía & histología , Giro del Cíngulo/fisiopatología , Hipocampo/anatomía & histología , Hipocampo/fisiopatología , Humanos , Masculino , Proyectos Piloto , Lóbulo Temporal/anatomía & histología , Vocabulario
16.
J Cogn Neurosci ; 13(7): 994-1005, 2001 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-11595101

RESUMEN

The detection of speech in an auditory stream is a requisite first step in processing spoken language. In this study, we used event-related fMRI to investigate the neural substrates mediating detection of speech compared with that of nonspeech auditory stimuli. Unlike previous studies addressing this issue, we contrasted speech with nonspeech analogues that were matched along key temporal and spectral dimensions. In an oddball detection task, listeners heard nonsense speech sounds, matched sine wave analogues (complex nonspeech), or single tones (simple nonspeech). Speech stimuli elicited significantly greater activation than both complex and simple nonspeech stimuli in classic receptive language areas, namely the middle temporal gyri bilaterally and in a locus lateralized to the left posterior superior temporal gyrus. In addition, speech activated a small cluster of the right inferior frontal gyrus. The activation of these areas in a simple detection task, which requires neither identification nor linguistic analysis, suggests they play a fundamental role in speech processing.


Asunto(s)
Percepción Auditiva/fisiología , Encéfalo/fisiología , Percepción del Habla/fisiología , Estimulación Acústica , Adulto , Atención/fisiología , Imagen Eco-Planar , Potenciales Evocados/fisiología , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Desempeño Psicomotor/fisiología , Reclutamiento Neurofisiológico/fisiología
17.
Psychophysiology ; 38(1): 133-42, 2001 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11321614

RESUMEN

We used event-related functional magnetic resonance imaging (erfMRI) techniques to examine the cerebral sites involved with target detection and novelty processing of auditory stimuli. Consistent with the results from a recent erfMRI study in the visual modality, target processing was associated with activation bilaterally in the anterior superior temporal gyrus, inferior and middle frontal gyrus, inferior and superior parietal lobules, anterior and posterior cingulate, thalamus, caudate, and the amygdala/hippocampal complex. Analyses of the novel stimuli revealed activation bilaterally in the inferior frontal gyrus, insula, inferior parietal lobule, and in the inferior, middle, and superior temporal gyri. These data suggest that the scalp recorded event-related potentials (e.g., N2 and P3) elicited during similar tasks reflect an ensemble of neural generators located in spatially remote cortical areas.


Asunto(s)
Percepción Auditiva/fisiología , Localización de Sonidos/fisiología , Estimulación Acústica , Adulto , Potenciales Evocados/fisiología , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino
18.
Neuroimage ; 13(4): 751-8, 2001 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-11305902

RESUMEN

Local signals obtained from BOLD fMRI are generally confounded by global effects. In this paper, we make an essential distinction between global effects and the global signal. Global effects have a similar influence on local signals from a large proportion of cerebral voxels. They may reflect diffuse physiological processes or variations in scanner sensitivity and are difficult to measure directly. Global effects are often estimated from the global signal, which is the spatial average of local signals from all cerebral voxels. If the global signal is strongly correlated with experimental manipulations, meaningfully different results may be obtained whether or not global effects are modeled (G. K. Aguirre et al., 1998, NeuroImage, 8, 302-306). In particular, if local BOLD signals make a significant contribution to the global signal, analyses using ANCOVAor proportional scaling models may yield artifactual deactivations. In this paper, we present a modification to the proportional scaling model that accounts for the contribution of local BOLD signals to the global signal. An event-related oddball stimulus paradigm and a block design working memory task were used to illustrate the efficacy of our model.


Asunto(s)
Mapeo Encefálico/métodos , Encéfalo/fisiología , Circulación Cerebrovascular/fisiología , Imagen por Resonancia Magnética/métodos , Modelos Teóricos , Oxígeno/sangre , Estimulación Acústica/métodos , Adulto , Femenino , Humanos , Masculino , Estimulación Luminosa/métodos
19.
Schizophr Res ; 48(2-3): 159-71, 2001 Mar 30.
Artículo en Inglés | MEDLINE | ID: mdl-11295369

RESUMEN

Schizophrenia is a diffuse brain disease that affects many facets of cognitive function. One of the most replicated findings in the neurobiology of schizophrenia is that the event-related potentials to auditory oddball stimuli are abnormal, effects believed to be related to abnormalities in attentional and memory processes. Although event-related potentials provide excellent resolution regarding the time course of information processing, such studies are poor at characterizing the spatial location of these abnormalities. To address this issue, we used event-related functional magnetic resonance imaging techniques to elucidate the neural areas underlying target detection in schizophrenia. Consistent with recent event-related functional magnetic resonance imaging results, target processing by control participants was associated with bilateral activation in the anterior superior temporal gyri, inferior and superior parietal lobules, and activation in anterior and posterior cingulate, thalamus, and right lateral frontal cortex. For the schizophrenic patients, selective deficits were observed in both the extent and strength of activation associated with target processing in the right lateral frontal cortex, thalamus, bilateral anterior superior temporal gyrus, anterior and posterior cingulate, and right inferior and superior parietal lobules. These findings are consistent with the evidence for abnormal processing of oddball stimuli suggested by event-related potential studies in schizophrenic patients, but provide much more detailed evidence regarding the anatomical sites implicated. These data are consistent with the hypothesis that schizophrenia is characterized by a widespread pathological process affecting many cerebral areas, including association cortex and thalamus.


Asunto(s)
Percepción Auditiva/fisiología , Encéfalo/anomalías , Encéfalo/fisiopatología , Potenciales Evocados Auditivos/fisiología , Imagen por Resonancia Magnética , Esquizofrenia , Adulto , Femenino , Humanos , Masculino , Esquizofrenia/diagnóstico , Esquizofrenia/etiología , Esquizofrenia/fisiopatología
20.
Hum Brain Mapp ; 12(2): 100-9, 2001 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11169874

RESUMEN

Event-related functional magnetic resonance imaging (erfMRI) was employed to measure the hemodynamic response during a Go/No-go task in 16 healthy subjects. The task was designed so that Go and No-go events were equally probable, allowing an unbiased comparison of cerebral activity during these two types of trials. In accordance with prediction, anterior cingulate was active during both the Go and No-go trials, dorsolateral and ventrolateral prefrontal cortex was more active during the No-go trials, while primary motor cortex, supplementary motor area, pre-motor cortex and cerebellum were more active during Go trials. These findings are consistent with the hypothesis that the anterior cingulate cortex is principally engaged in making and monitoring of decisions, while dorsolateral and ventral lateral prefrontal sites play a specific role in response inhibition.


Asunto(s)
Conducta/fisiología , Encéfalo/fisiología , Toma de Decisiones/fisiología , Imagen por Resonancia Magnética , Adulto , Mapeo Encefálico , Femenino , Humanos , Masculino
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