Stimulus Selection Based on Gender Ratios: Gender Ratios are Indicative of Both Stereotypical and Conceptual Gender.

This paper explores how the use of gender ratios to inform stimulus selection affects the activation of gendered social information. It investigates if stimuli selected this way can activate gender stereotype knowledge and/or conceptual gender knowledge. This was tested through attribute naming (Study 1) and rating (Study 2) tasks, with component and regression analysis allowing for examination of the nature of gender ratios at both attribute and component levels. The results provide rich information about the nature of gender ratio information as a means of stimulus selection, and in doing so support both conceptualisations as long as researchers acknowledge their overlap. The results also indicate that these roles elicited both positive/prescriptive (i.e., the role is appropriate for a given gender) and negative/proscriptive beliefs (i.e., the role is not appropriate for a given gender). These findings hold important implications for future research using gender ratios.

Exploring the comparative adequacy of a unimanual and a bimanual stimulus-response setup for use with three-alternative choice response time tasks.

Research often conceptualises complex social factors as being distinct binary categories (e.g., female vs male, feminine vs masculine). While this can be appropriate, the addition of an 'overlapping' category (e.g., non-binary, gender neutral) can contextualise the 'binary', both for participants (allowing more complex conceptualisations of the categories than the 'either/or' conceptualisation in binary tasks), and for the results (by providing a neutral baseline for comparison). However, it is not clear what the best response setup for such a task would be. In this study, we explore this topic through comparing a unimanual (N = 34) and a bimanual response setup (N = 32) for use with a three-alternative choice response time task. Crucially, one of the stimulus categories ('mixed') was composed of stimulus elements from the other two stimulus categories used in that task (Complex Task). A reference button task was included to isolate the motoric component of response registration (Simple Task). The results of the simple task indicated lower motoric costs for the unimanual compared to the bimanual setup. However, when statistically controlling for these motoric costs in the complex task, the bimanual setup had a lower error rate and faster response times than the unimanual setup. Further, in the complex task error rates and response times were higher for the mixed than the matched stimuli, indicating that responding to mixed stimuli is more challenging for encoding and/or decision making processes. This difference was more pronounced in the unimanual than the bimanual setup. Taken together these results indicate that the unimanual setup is more adequate for the reference button task, whereas the intricacy of overlapping categories in the complex task is better contained in the bimanual setup, i.e. when some response alternatives are allocated to one hand and other alternatives to the other hand.

A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity.

Rab proteins are conserved small GTPases that coordinate intracellular trafficking essential to cellular function and homeostasis. RAB-6.2 is a highly conserved C. elegans ortholog of human RAB6 proteins. RAB-6.2 is expressed in most tissues in C. elegans and is known to function in neurons and in the intestine to mediate retrograde trafficking. Here, we show that RAB-6.2 is necessary for cuticle integrity and impermeability in C. elegans RAB-6.2 functions in the epidermis to instruct skin integrity. Significantly, we show that expression of a mouse RAB6A cDNA can rescue defects in C. elegans epidermis caused by lack of RAB-6.2, suggesting functional conservation across phyla. We also show that the novel function of RAB-6.2 in C. elegans cuticle development is distinct from its previously described function in neurons. Exocyst mutants partially phenocopy rab-6.2-null animals, and rab-6.2-null animals phenocopy mutants that have defective surface glycosylation. These results suggest that RAB-6.2 may mediate the trafficking of one or many secreted glycosylated cuticle proteins directly, or might act indirectly by trafficking glycosylation enzymes to their correct intracellular localization.

Susceptibility to Cryptococcal Meningoencephalitis Associated With Idiopathic CD4+ Lymphopenia and Secondary Germline or Acquired Defects.

Idiopathic CD4+ lymphopenia (ICL) predisposes to opportunistic infections (OIs) but can often remain asymptomatic and does not have a strong association with monogenic mutations. Likewise, cryptococcal meningoencephalitis, the most common OI in ICL, is not strongly associated with monogenic mutations. In this study, we describe 2 patients with ICL plus an additional immune defect: one from an E57K genetic mutation in the nuclear factor-κß essential modulator, and the other with acquired autoantibodies to granulocyte-macrophage colony-stimulating factor. Thus, these cases may exemplify a "multi-hit model" in patients with ICL who acquire OIs.

The Effect of Differences in Day and Night Lighting Distributions on Drivers' Speed Perception.

Previous research has shown that changes to contrast levels in the visual environment caused by fog can affect drivers' perceptions of speed. It is not easy, however, to extrapolate these results to other driving scenarios in which contrast is affected, such as during nighttime driving, because the measure of contrast is more complex when considering factors such as the illumination provided by headlights. Therefore, we investigated the differences in lighting distribution patterns between day- and nighttime driving on speed perception using prerendered 3D scenarios representing driving on a rural road. A two-alternative forced-choice design based on the method of constant stimuli was utilised, with 32 participants viewing a series of pairs of scenarios (day vs. night driving) from a driver's perspective while indicating for each pair whether the second scenario was faster or slower than the first scenario. Our results indicated that speed discrimination accuracy was minimally affected by changes in lighting distribution patterns between day and night.