RESUMEN
Psychotropic properties of CA-7043× and CA-7050×, new fluorinated derivatives of tetrahydrocarbasoles, were examined on outbred CD1 mice and transgenic 5×FAD mice with Alzheimer disease. Both agents exerted cognitive-stimulating and anxiolytic effects in a dose of 5 mg/kg. In the new cage test, they retarded extinction of orientation and exploratory behavior. CA-7043× produced an anxiolytic effect on CD1 mice assessed in the open-field test and exerted cognitive-stimulating action in the new location test. In the same tests, CA-7050× demonstrated the cognitive-stimulating and anxiolytic effects on transgenic 5×FAD mice.
Asunto(s)
Ansiolíticos/farmacología , Ansiedad/tratamiento farmacológico , Conducta Animal/efectos de los fármacos , Carbazoles/farmacología , Conducta Exploratoria/efectos de los fármacos , Hidrocarburos Fluorados/farmacología , Aprendizaje por Laberinto/efectos de los fármacos , Psicotrópicos/farmacología , Enfermedad de Alzheimer/tratamiento farmacológico , Animales , Modelos Animales de Enfermedad , Masculino , Ratones , Ratones TransgénicosRESUMEN
Compound NT1505 potentiates AMPA receptors in rat brain neurons and simultaneously noncompetitively blocks NMDA receptors via two different mechanisms. Considering previously obtained data on strong cognition-enhancing properties of this compound we can conclude that NT1505 is a novel cognition stimulator exhibiting properties of a positive modulator of AMPA receptors and a blocker NMDA receptor.
Asunto(s)
Nootrópicos/farmacología , Receptores de Glutamato/metabolismo , Animales , Células Cultivadas , Electrofisiología , Células de Purkinje/efectos de los fármacos , Células de Purkinje/metabolismo , Ratas , Receptores AMPA/agonistas , Receptores AMPA/metabolismo , Receptores de N-Metil-D-Aspartato/agonistas , Receptores de N-Metil-D-Aspartato/metabolismoRESUMEN
Mexidol therapy inhibited cyclophosphamide-induced myelosuppression in C57B1/6 line mice with Lewis lung carcinoma without affecting antitumor action of the latter. Mexidol plus cyclophosphamide proved more effective in prophylaxis of metastasis as compared with the cytostatic alone.
Asunto(s)
Antineoplásicos/farmacología , Médula Ósea/efectos de los fármacos , Carcinoma Pulmonar de Lewis/tratamiento farmacológico , Ciclofosfamida/efectos adversos , Ciclofosfamida/farmacología , Picolinas/farmacología , Animales , Antineoplásicos Alquilantes/efectos adversos , Antineoplásicos Alquilantes/farmacología , Carcinoma Pulmonar de Lewis/sangre , Carcinoma Pulmonar de Lewis/patología , Eritrocitos/efectos de los fármacos , Hemoglobinas/efectos de los fármacos , Leucocitos/efectos de los fármacos , Linfocitos/efectos de los fármacos , Ratones , Ratones Endogámicos C57BL , Agonistas Mieloablativos/efectos adversos , Agonistas Mieloablativos/farmacología , Neutrófilos/efectos de los fármacosRESUMEN
Changes of the histological structure of rat's skin were studied two weeks following the daily applications of native birch tar and of purified birch tar, devoid of the components that could be potentially dangerous for humans. The morphometric investigations were performed with the use of computer technologies on the apparatus-programme complex (DiaMorph, Russia). It has been established that the main morphological manifestations of specific dermatotropic activity of birch tar in the present experiment included: epidermal hypertrophy, hyperkeratosis, stimulation of the activity of all dermal cellular elements, intensification of blood supply, reduction of sebaceous glands. Analysis of morphological findings indicates the bioequivalence of the native and purified birch tar in terms of its specific dermatotropic activity.
Asunto(s)
Betula/química , Piel/citología , Piel/efectos de los fármacos , Breas/toxicidad , Animales , RatasRESUMEN
The murine bone marrow cellular chromosomal aberration technique was used to reveal anticlastogenic effects of the natural interferon inductors ridostin and larifan, as well as the synthetic ones polyguacil and amyxin. The action of the interferon inductors was timed to the maximum production of interferon in the body. Anticarcinogenic, antitumor, and antimetastatic properties of the above interferon inductors were found by using classical experimental models of carcinogenesis. Some mechanisms of antimutagenic and coupled anticarcinogenic action of interferon inductors were considered. The natural interferon inductor larifan was found to have an antipromoter activity. The treatment regimen by using interferon inductors in combination with the immunomodulator thymosin, a thymic hormone, was under discussion.
Asunto(s)
Antimutagênicos/farmacología , Inductores de Interferón/farmacología , Neoplasias Experimentales/tratamiento farmacológico , Animales , Médula Ósea/efectos de los fármacos , Células de la Médula Ósea , Aberraciones Cromosómicas , Quimioterapia Combinada , Inductores de Interferón/administración & dosificación , Inductores de Interferón/uso terapéutico , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Neoplasias Experimentales/inducido químicamente , Compuestos Orgánicos , Poli C/farmacología , Poli G/farmacología , ARN Bicatenario/farmacología , ARN de Hongos/farmacología , Ratas , Ratas Wistar , Timosina/administración & dosificación , Timosina/uso terapéutico , Tilorona/farmacologíaAsunto(s)
Dinoprostona/farmacología , Neoplasias Pulmonares/sangre , Prostaglandinas/sangre , Animales , División Celular/efectos de los fármacos , Femenino , Neoplasias Pulmonares/patología , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos , Metástasis de la Neoplasia , Tromboxano B2/sangreRESUMEN
The cancerogenic activity of the dispirotripiperasinium derivatives prospidine and spirobromine was tested in concurrent use with sodium nitrite. The drugs were intragastrically administered once a week. It was combined with sodium nitrite, 35 mg/kg, to non-inbred rats of both sex during 24 months. A morphological study revealed no statistically significant reduction of latency and no increase in the incidence of tumors in laboratory animals. No cancerogenic effect of sodium nitrite was found.
Asunto(s)
Carcinógenos/toxicidad , Cocarcinogénesis , Piperazinas/toxicidad , Nitrito de Sodio/toxicidad , Compuestos de Espiro/toxicidad , Administración Oral , Animales , Antineoplásicos/administración & dosificación , Antineoplásicos/toxicidad , Carcinógenos/administración & dosificación , Distribución de Chi-Cuadrado , Femenino , Incidencia , Masculino , Neoplasias Experimentales/inducido químicamente , Neoplasias Experimentales/epidemiología , Piperazinas/administración & dosificación , Prospidio/administración & dosificación , Prospidio/toxicidad , Ratas , Nitrito de Sodio/administración & dosificación , Compuestos de Espiro/administración & dosificaciónAsunto(s)
Antimutagênicos/uso terapéutico , Antineoplásicos/uso terapéutico , Aziridinas/uso terapéutico , Carcinoma Pulmonar de Lewis/tratamiento farmacológico , Inductores de Interferón/uso terapéutico , Mutágenos/uso terapéutico , Animales , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Médula Ósea/efectos de los fármacos , Médula Ósea/ultraestructura , Carcinoma Pulmonar de Lewis/genética , Carcinoma Pulmonar de Lewis/ultraestructura , Aberraciones Cromosómicas/genética , Ensayos de Selección de Medicamentos Antitumorales , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Metástasis de la Neoplasia , Trasplante de Neoplasias , Compuestos Orgánicos , Factores de TiempoRESUMEN
The paper deals with the effect of carbon tetrachloride-induced hepatopathy on pattern of spontaneous dissemination of Lewis tumor transplanted to C57B1/6 mice. Antitumor drugs vincristine and rubomycin prevented dissemination to the liver but failed to arrest spreading to the lung.
Asunto(s)
Intoxicación por Tetracloruro de Carbono/patología , Carcinoma de Células Escamosas/patología , Enfermedad Hepática Inducida por Sustancias y Drogas/patología , Neoplasias Pulmonares/patología , Animales , Intoxicación por Tetracloruro de Carbono/tratamiento farmacológico , Intoxicación por Tetracloruro de Carbono/metabolismo , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/tratamiento farmacológico , Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico , Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo , Daunorrubicina/uso terapéutico , Ensayos de Selección de Medicamentos Antitumorales , Femenino , Lípidos/análisis , Hígado/química , Hígado/efectos de los fármacos , Hígado/patología , Neoplasias Pulmonares/química , Neoplasias Pulmonares/tratamiento farmacológico , Masculino , Ratones , Ratones Endogámicos C57BL , Metástasis de la Neoplasia , Trasplante de Neoplasias , Vincristina/uso terapéuticoRESUMEN
Results of a study of the pattern of spontaneous dissemination of Lewis lung carcinoma in male mice with reproductive system dysfunction showed that removal of the gonads followed by substitution treatment with testosterone failed to influence tumor metastatic potential. The data suggested that the androgen lacked a modulating effect on growth and dissemination of Lewis lung carcinoma.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias Pulmonares/patología , Testículo/fisiología , Animales , Carcinoma de Células Escamosas/sangre , Inyecciones Subcutáneas , Neoplasias Pulmonares/sangre , Masculino , Ratones , Ratones Endogámicos C57BL , Metástasis de la Neoplasia , Orquiectomía , Testosterona/administración & dosificación , Factores de TiempoRESUMEN
The effect of prospidin on Lewis lung carcinoma spreading under hyper- and hypocalcemia was studied. At early stages, increased extracellular calcium level was associated with inhibition of tumor dissemination to the lungs; however, later, colony growth was stimulated. Extracellular calcium level was shown to modulate the antitumor and antimetastatic effect of prospidin.