Analysis for Predictors of Failure of Orthodontic Mini-implant Using Patient-Specific Finite Element Models.

In this study, we analyzed the clinical factors and mechanical parameters for predicting orthodontic mini-implant (OMI) failure in the mandible, which has different properties from the maxilla. A patient-specific finite element analysis was applied to 32 OMIs (6 failures and 26 successes) implanted between the mandibular second premolars and first molars used for anchorage. The peak stress and strain parameters were calculated for each sample. A logistic regression of the failure (vs. success) of OMIs on the mechanical parameters in the models was conducted. In addition, the influence of clinical factors on the mechanical parameters considered to be related to OMI failure was examined by a regression analysis. The mechanical parameter which best predicts OMI failure in the mandible was found to be a minimum principal strain of between 0.5 to 1.0 mm from the OMI surface (R2 = 0.8033). The results indicate the patient's bone density, distance between the OMIs and adjacent root, and vertical implantation angle of the OMIs are potential clinical predictors of OMI failure in the mandible.

Molecular imaging in masseter muscle observed by muscle function magnetic resonance imaging and 31 P-magnetic resonance spectroscopy in patients with a jaw deformity.

BACKGROUND: Skeletal mandibular protrusion would influence to the muscle fatigue of the masticatory muscles. Establishing a diagnostic procedures combining physiological and biochemical information is necessary for quantitative evaluation of masticatory muscle fatigue. OBJECTIVE: The transverse relaxation time (T2 time) of muscle functional magnetic resonance imaging (mfMRI), and 31 P-magnetic resonance spectroscopy (MRS) were used to investigate the reliability as parameters for measuring the masseter muscle in patients with skeletal mandibular prognathism. METHOD: The subjects were 19 patients diagnosed as skeletal mandibular protrusions and 19 healthy subjects as a control group. Transverse relaxation time (T2 value) determined by mfMRI along with creatine phosphate (PCr) and inorganic phosphorus (Pi) determined by 31 P-MRS before, during, and after clenching were used for molecular imaging of muscle fatigue. RESULTS: The average T2 value of the patient group was significantly higher than that of the healthy control group at rest. Furthermore, the average T2 value transiently increased in both groups during experimental clenching. The PCr and Pi showed a tendency toward a transient decrease and increases, respectively. The pH in the masseter muscle showed a transient decrease in both groups prior to and following experimental clenching. The pH in the masseter muscle of the patient group was significantly lower than that in the healthy control group at rest and recovery. CONCLUSION: We showed mfMRI and 31 P-MRS are useful for evaluating masseter fatigue during clenching, and the masseter muscle in the prognathic patients showed more severe fatigue than the healthy controls.

Predisposing Factors for Orthodontic Mini-Implant Failure Defined by Bone Strains in Patient-Specific Finite Element Models.

Factors responsible for the success or failure of orthodontic mini-implants (OMIs) in clinical settings are unclear. Failure of OMIs was found to be associated with increased maximum principal strain (MaxPN) when assessed using the subject-specific finite element (FE) modeling technique. The purpose of the present study was to identify factors that increase MaxPN and thereby predispose the OMI to failure. Using the FE method, MaxPN was calculated around 28 OMIs placed in orthodontic patients, 6 of which failed during the first 5 months. Sixteen potential risk factors related to patients or to OMI position were measured on computerized tomographic images or calculated in FE models. The impact of these factors on MaxPN was verified using regression analysis. Three factors were found to have significant nonlinear relationships with MaxPN: cortical bone quality, vertical angulation of the OMI, and proximity of the OMI to the tooth in the direction of force. In conclusion, failure of an OMI is a multifactorial problem, and position and angulation of the implant are among the affecting factors. Slight apical inclination and positioning at least 1 mm off the root in the direction of force may significantly decrease failure probability.

Maximum principal strain as a criterion for prediction of orthodontic mini-implants failure in subject-specific finite element models.

OBJECTIVE: To investigate the most reliable stress or strain parameters in subject-specific finite element (FE) models to predict success or failure of orthodontic mini-implants (OMIs). MATERIALS AND METHODS: Subject-specific FE analysis was applied to 28 OMIs used for anchorage. Each model was developed using two computed tomography data sets, the first taken before OMI placement and the second taken immediately after placement. Of the 28 OMIs, 6 failed during the first 5 months, and 22 were successful. The bone compartment was divided into four zones in the FE models, and peak stress and strain parameters were calculated for each. Logistic regression of the failure (vs success) of OMIs on the stress and strain parameters in the models was conducted to verify the ability of these parameters to predict OMI failure. RESULTS: Failure was significantly dependent on principal strain parameters rather than stress parameters. Peak maximum principal strain in the bone 0.5 to 1 mm from the OMI surface was the best predictor of failure (R(2) = 0.8151). CONCLUSIONS: We propose the use of the maximum principal strain as a criterion for predicting OMI failure in FE models.

Effects of extraction of four premolars on vermilion height and lip area in patients with bimaxillary protrusion.

The purpose of this study was to evaluate the effects of orthodontic treatment, involving the extraction of four premolars, on vermilion height and lip area. Twenty-eight female patients (mean 21.9 ± 3.1 years) who were diagnosed with bimaxillary protrusion were selected for this study to be treated by extraction of four premolars. The control group consisted of 28 female volunteers (mean 25.0 ± 3.0 years) with Angle Class I normal occlusion. Frontal photographs of the patients were taken both before and after the orthodontic treatment in resting position. Thirty-five landmarks on the upper and lower lips were identified for the measurements of vermilion height and lip area. Lateral cephalograms were taken before and after active orthodontic treatment, and linear and angular measurements were performed. The mean pre-treatment values of vermilion height and lip area were significantly greater in the treatment group than those of the control group and decreased significantly after the orthodontic treatment towards the values in the control group. There were no significant differences in the vermilion height and lip area between the post-treatment and the control groups, except for lower lip area values. Significant correlations found between the changes in incisor position and the changes in vermilion height were few in number for the upper lip but greater in number for the lower lip. Thus, the results of this study show that bimaxillary protrusion cases can be treated by the extraction of four premolars to produce an aesthetic improvement in frontal facial features.

Effects of four premolar extractions on vermilion height and lip area during a posed smile in patients with bimaxillary protrusion.

OBJECTIVE: The purpose of this study was to evaluate the effects of four premolar extractions and orthodontic treatment on changes to the lips and vermilion height during a posed smile. METHODS: Fifteen female patients who were diagnosed with bimaxillary protrusion and treated with four premolar extractions were selected. The control group consisted of 25 female volunteers with a normal occlusion. Frontal photographs of the patients during a posed smile were taken before and after orthodontic treatment. Thirty-five landmarks on the upper and lower lips were identified and used to generate measurements of lip area and vermilion height. Linear and angular cephalometric measurements were also obtained. RESULTS: The mean values for vermilion height and lip form before orthodontic treatment were significantly larger in the treatment group compared with those of the control group. Following treatment, values significantly decreased to the extent that there was no significant difference in the vermilion height and lip form between the post-treatment and control groups. Only three and four significant correlations were found between the changes in incisor position and changes in vermilion height and lip area for the upper and lower lips, respectively. CONCLUSIONS: The vermilion height and lip area in patients with bimaxillary protrusion approached comparative and normal values as a result of four premolar extractions and orthodontic retraction.

Three-dimensional analysis of the pharyngeal airway morphology in growing Japanese girls with and without cleft lip and palate.

INTRODUCTION: We evaluated the 3-dimensional craniofacial skeletal and pharyngeal airway morphology in growing patients with and without cleft lip and palate. METHODS: Our juvenile subjects consisted of 34 girls (ages, 9-12 years); 15 had cleft lip and palate, and 19 did not. The adolescent subjects consisted of 32 girls (ages, 13-17 years); 14 had cleft lip and palate, and 18 did not. Each subject was examined with cone-beam computed tomography. The dimensions of the craniofacial skeleton and pharyngeal airway were measured. The Scheffé method of multiple comparisons was used to identify relationships among skeletal and pharyngeal variables. RESULTS: The pharyngeal airway and mandibular size variables did not differ significantly between the juvenile and adolescent cleft lip and palate groups. Significant differences were observed between each cleft lip and palate group and its corresponding control group. FHN-A, FHN-B, FH-NA, FH-NB, and Co-Me were significantly smaller in the cleft lip and palate groups than in the corresponding control groups. Anteroposterior and lateral widths, heights, and volumes of the superior oropharyngeal airway were significantly smaller in the adolescent cleft lip and palate group than in the adolescent controls. CONCLUSIONS: The mandible and the oropharyngeal airway were larger in the adolescent controls than in the juvenile controls without cleft lip and palate, but there were no significant differences between the adolescent and juvenile patients with cleft lip and palate.

Changes in the pharyngeal airway space and hyoid bone position after mandibular setback surgery for skeletal Class III jaw deformity in Japanese women.

INTRODUCTION: The purpose of the study was to examine the changes in stability of pharyngeal airway space (PAS) and hyoid bone position after 2 types of mandibular osteotomies in comparison with a control group. METHODS: The subjects included 46 Japanese women with skeletal Class III malocclusion. Twenty-five patients with mandibular prognathism underwent single-jaw surgery with bilateral sagittal split ramus osteotomy (SSRO), and 21 patients underwent bilateral intraoral vertical ramus osteotomy (IVRO). The control subjects included 30 volunteer women with normal occlusion. The treated subjects were assessed at the beginning of treatment, immediately after surgery, and after postsurgical treatment. RESULTS: The Class III subjects had a significantly wider PAS than did the control subjects. Significant decreases in the lower PAS were observed after orthognathic surgery. The hyoid bone showed upward and forward movement with upward movement of the lower border of the PAS during the postsurgical stage in the SSRO group. In contrast, the anterior border of the PAS and the hyoid bone showed considerable backward movement in the IVRO group. CONCLUSIONS: The posttreatment morphology of the PAS in both Class III groups approached that of the control group. The IVRO group showed a reduction in the airway dimensions, especially during the postsurgical period, which occurred during surgery in the SSRO group.

Lip morphology changes following orthognathic surgery for Class III malocclusion.

OBJECTIVES: To test the hypothesis that there is no difference in the morphology of the lips and to determine the degree of improvement in the smile after orthognathic surgery for Class III malocclusion. MATERIALS AND METHODS: The sample subjects included 30 adult female patients with dento-skeletal Class III malocclusion and 28 adult female volunteers with normal occlusion. Frontal facial photographs were taken before and after treatment, and 35 landmarks were placed on each tracing made from the frontal facial photograph. Thereafter, the landmarks were digitized into an x and y coordinate system with the subnasal point as the origin. The pretreatment rest and smile conditions were compared with the posttreatment conditions, respectively, using paired t-tests. In addition, two sample t-tests were used to test for differences between groups. RESULTS: Both the upper and lower lips in the smiles of the Class III pretreatment group were positioned downward, and the upward movement of the upper lip and commissure points were smaller compared with the control group. When smiling, the horizontal direction of the mouth corners was statistically significantly different between the pretreatment and posttreatment conditions, whereas these were wider in the posttreatment than in the pretreatment conditions. These characteristics of the Class III smile improved after orthognathic treatment, but the differences with the control group remained unchanged immediately after treatment. CONCLUSION: The hypothesis is rejected. The soft tissue morphology of patients with dento-skeletal Class III malocclusion shows a significant improvement after orthognathic surgery.

Orthognathic treatment with autotransplantation of impacted maxillary third molar.

This article presents orthognathic treatment in successful collaboration with autotransplantation of the maxillary third molar. The case report describes a 24-year-old man with severe mandibular protrusion and severe crowding in both dentitions. Overbite was 0 mm, overjet, -15 mm. Maxillary second molars and mandibular third molars were extracted, and presurgical multibracket treatment was begun. Maxillary third molars were impacted completely at 18 months in terms of presurgical tooth alignment. Autotransplantation of the teeth was achieved to substitute for extracted maxillary second molars. At 6 months after autotransplantation, the maxilla was advanced 4 mm on both sides through a Le Fort I procedure; left and right sides of the mandible were set back 15 and 18 mm, respectively, via sagittal split ramus osteotomy to improve mandibular protrusion. The total treatment period lasted 37 months. Autotransplantation treatment is an effective modality for tooth replacement when a donor tooth is available. Fully impacted maxillary third molars are potentially reliable candidates for autotransplantation.

Lip morphological changes in orthodontic treatment. Class II division 1: malocclusion and normal occlusion at rest and on smiling.

OBJECTIVE: To evaluate the morphological changes in the lips and to determine the degree of improvement in the smile after orthodontic treatment for Class II division 1 malocclusion. MATERIALS AND METHODS: The sample subjects were divided into two groups: a group that consisted of 20 adult female patients with Angle Class II division 1 malocclusion and a control group that consisted of 28 adult female volunteers with normal occlusion. Frontal photographs were taken before and after orthodontic treatment, and 35 landmarks were placed on each tracing made from the photograph. Thereafter, landmarks were digitized into an x- and y-coordinate system with the subnasal point as the origin. The comparisons between pretreatment and posttreatment at rest and on smiling, and the comparisons between Class II division 1 and control group were made using Student's t-test. RESULTS: Both the upper and lower lips in the smile of patients in the Class II division 1 pretreatment group were positioned downward, and the upward movement of the upper lip and mouth corners was smaller in comparison with the control group. These characteristics of the Class II smile improved after orthodontic treatment, but the differences with the control group remained unchanged immediately after treatment. CONCLUSION: The soft tissue morphology shows a relative improvement after orthodontic treatment.

Hard and soft tissue stability of orthognathic surgery.

OBJECTIVE: To test the hypothesis that there is no difference in the stability of the hard and soft tissue changes following a surgical mandibular setback using a sagittal split ramus osteotomy or an intraoral vertical ramus osteotomy. MATERIALS AND METHODS: The samples consisted of 45 female patients with mandibular prognathism, who were divided into two groups. Twenty-three underwent a sagittal split ramus osteotomy (SSRO) with rigid fixation by titanium mini-screws and maxillomandibular fixation (MMF) for 14.0 +/- 0.7 days. Twenty-two underwent intraoral vertical ramus osteotomy (IVRO) without rigid fixation, and MMF was released 21.5 +/- 3.3 days after surgery. Data were collected from standardized cephalometric radiographs taken at the start of preoperative orthodontic treatment (T1), immediately after surgery (MMF, T2), and the completion of postoperative treatment (T3). Angular measurements were compared on each of T1, T2, and T3. RESULTS: There were no significant differences in the pretreatment hard and soft tissue morphology between the SSRO and IVRO. However, when fixation was released, the mandible was posteriorly positioned in the IVRO group. In the soft tissue profile, the mental region was located backward in the IVRO group at postoperative stage (T3). CONCLUSIONS: The hypothesis is rejected. The soft tissue profile of the IVRO group especially showed a retromandibular position after postoperative treatment in comparison with the SSRO group. This tendency of the IVRO group would contribute to the database for treatment planning and prediction.