RESUMEN
Solid state dynamic properties have been investigated for the racemic (DL) and enantiomerically pure (L) crystalline forms of the amino acid serine [HO x CH2 x CH(NH3(+)) x CO2(-)] using 2H NMR line shape analysis and 2H NMR spin-lattice relaxation time measurements for samples of DL-serine and L-serine deuterated in the NH3(+) and OH groups. 2H NMR line shape analysis indicates that, for both L-serine and DL-serine, the ND3(+) group undergoes a 3-site 120 degrees jump motion, with jump frequencies in the intermediate motion regime (10(3) s(-1) to 10(8) s(-1)) in the temperature range 153-313 K. However, at a given temperature, the jump frequency is substantially higher for L-serine (e.g., at 233 K, the jump frequency is 5.0 x 10(6) s(-1) for L-serine and 6.0 x 10(4) s(-1) for DL-serine). The OD group is not dynamic on the 2H NMR time scale within the temperature range studied. The results from both 2H NMR line shape analysis (LA) and 2H NMR spin-lattice relaxation time measurements (SLR) indicate that the activation energy for the 3-site 120 degree jump motion of the ND3(+) group is significantly higher for DL-serine [38.0 +/- 1.0 kJ mol(-1) (LA); 39.7 +/- 0.8 kJ mol(-1) (SLR)] than for L-serine [23.4 +/- 0.8 kJ mol(-1) (LA); 23.8 +/- 0.3 kJ mol(-1) (SLR)]. The difference in activation energies between DL-serine and L-serine is substantially greater than any reported previously for an amino acid in different crystal forms.
Asunto(s)
Aminoácidos/química , Cristalización , Espectroscopía de Resonancia Magnética , Serina/química , Estereoisomerismo , TermodinámicaRESUMEN
Bupivacaine belongs to a family of 1-alkyl-2',6'-pipecoloxylidides, which has shown promise as reversible action potential blockers that can introduce prolonged local anesthetic effects. The crystal structure of the free-base form of bupivacaine has been determined directly from powder X-ray diffraction data using the Genetic Algorithm technique for structure solution, followed by Rietveld refinement. This work further emphasizes the scope and utility of ab initio structure solution directly from powder X-ray diffraction data for tackling structural problems within the biomedical field, leading to opportunities for the investigation of structure-property relationships.
Asunto(s)
Anestésicos Locales/química , Bupivacaína/química , Anestésicos Locales/análisis , Bupivacaína/análisis , Cristalografía por Rayos X/métodos , Estructura Molecular , PolvosRESUMEN
A three-component molecular cocrystal material has been prepared by a solvent-free route involving mechanical grinding of the pure phases of the individual components. This material is not accessible from conventional solution-state crystallization procedures. Due to the fact that the grinding procedure intrinsically leads to a microcrystalline powder sample, the use of powder X-ray diffraction data is essential for structure determination. This work emphasizes the scope and utility of ab initio structure solution directly from powder X-ray diffraction data for carrying out structural characterization of new materials prepared via the solid-state grinding route, leading to the opportunity to establish structure-property relationships for such materials.
RESUMEN
The transformation of ammonium cyanate into urea, first studied over 170 years ago by Wöhler and Liebig, has an important place in the history of chemistry. To understand the nature of this solid state reaction, knowledge of the crystal structure of ammonium cyanate is a prerequisite. Employing neutron powder diffraction, we demonstrate conclusively that, in the structure of ammonium cyanate, the NH(4)(+) cation forms N-H...N hydrogen bonds to four cyanate N atoms at alternate corners of a distorted cube, rather than our previously proposed alternative arrangement with N-H...O hydrogen bonds to cyanate O atoms at the other four corners.