RESUMEN
Skin often represents a target organ for adverse drug reactions and this also applies to the mRNA vaccines against Sars-CoV-2. Here we present a case of extensive livedoid reaction after 2nd dose of BNT162b-2 vaccine with massive blood skin extravasation and no systemic symptoms apart from anemization. The 30-year-old woman developed progressively enlarging livedoid lesions on limbs and abdomen. Histology showed a near-normal epidermis and a very mild interstitial mixed inflammatory infiltrate with extensive blood extravasation in mid- and deep dermis. Diagnosis was adverse reaction to vaccine with skin capillary hyperpermeability and anaemization with lower than diagnostic features of cutaneous small vessel vasculitis. To date, no cases of a livedoid skin reaction associated to Covid-19 vaccine have been reported, and this case illustrates that massive livedoid reaction can be another kind of skin reaction to mRNA Covid-19 vaccine.
Asunto(s)
Vacunas contra la COVID-19 , COVID-19 , Adulto , COVID-19/diagnóstico , COVID-19/prevención & control , Vacunas contra la COVID-19/efectos adversos , Femenino , Humanos , ARN Mensajero , SARS-CoV-2 , Piel/patologíaAsunto(s)
Antirreumáticos , Artritis Reumatoide , Meningitis Aséptica , Adalimumab/efectos adversos , Antirreumáticos/efectos adversos , Artritis Reumatoide/tratamiento farmacológico , Humanos , Meningitis Aséptica/inducido químicamente , Meningitis Aséptica/diagnóstico , Meningitis Aséptica/tratamiento farmacológicoAsunto(s)
Síndrome de Inmunodeficiencia Adquirida/patología , Síndrome de Inmunodeficiencia Adquirida/virología , Úlcera del Pie/patología , Úlcera del Pie/virología , Herpesvirus Humano 1 , Síndrome de Inmunodeficiencia Adquirida/tratamiento farmacológico , Aciclovir/análogos & derivados , Aciclovir/uso terapéutico , Antiinfecciosos Locales/uso terapéutico , Antivirales/uso terapéutico , Úlcera del Pie/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Valaciclovir , Valina/análogos & derivados , Valina/uso terapéuticoRESUMEN
Hematogenous bone metastases from endometrial carcinoma are not frequent and their treatment is a matter of debate. We describe an extremely rare case of calvarial metastasis from endometrial carcinoma in an 80-year-old woman treated by means of one-step surgical radical resection and heterologous cranioplasty, along with a review of the literature regarding epidemiology, clinico-radiological features, prognosis, and management of skull metastases.
