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1.
Stem Cells Transl Med ; 13(4): 317-331, 2024 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-38394392

RESUMEN

Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of retinal pigment epithelial cells and/or photoreceptors as a treatment for these conditions are underway. In this review, we summarize recent progress in the field of retinal pigment epithelium transplantation, including some pertinent clinical trial results as well as preclinical studies that address issues of transplant immunology, cell delivery, and cell manufacturing.


Asunto(s)
Degeneración Macular , Enfermedades de la Retina , Humanos , Epitelio Pigmentado de la Retina , Trasplante de Células Madre/métodos , Enfermedades de la Retina/terapia , Retina , Degeneración Macular/terapia
2.
Stem Cells Transl Med ; 13(4): 332-345, 2024 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-38417110

RESUMEN

Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of photoreceptors as treatment for these conditions are underway. In this review, we summarize recent progress in the field of photoreceptor transplantation, including some pertinent results regarding photoreceptor manufacture, photoreceptor transplantation, mechanisms of donor-host cell integration such as material transfer and photoreceptor transplant immunology. We conclude by proposing several approaches that may provide a rational basis for selecting a vision restoration strategy (eg, donor-host synapse formation vs donor-host nanotube formation) and improved transplant efficiency.


Asunto(s)
Degeneración Macular , Degeneración Retiniana , Humanos , Degeneración Retiniana/terapia , Retina , Degeneración Macular/terapia , Células Fotorreceptoras , Tratamiento Basado en Trasplante de Células y Tejidos , Trasplante de Células Madre/métodos
3.
Case Rep Gastrointest Med ; 2022: 1047334, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35433062

RESUMEN

Carcinosarcoma is a rare malignant neoplasm that is composed of both epithelial and mesenchymal tumor components. Gastric carcinosarcoma is even more rare and is often diagnosed at a late stage. In this report, we investigate a case of early gastric carcinosarcoma with regional lymph node metastasis in a 78-year-old woman. The patient underwent partial gastrectomy, lymphadenectomy, and splenectomy. The tumor was confined to the gastric submucosa, and a biopsy specimen led to a histological diagnosis of carcinosarcoma with adenocarcinoma, squamous-cell carcinoma, and undifferentiated pleomorphic sarcoma components. Metastasis was present in one lymph node and displayed osteosarcomatous differentiation. Vigilant monitoring for recurrence and metastatic disease will be required for this patient.

4.
Case Rep Gastrointest Med ; 2021: 6629424, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33628534

RESUMEN

Sclerosing mesenteritis (SM) is a rare inflammatory condition with unknown etiology that affects the mesenteric adipose tissue. We present a case of a 49-year-old male with severe abdominal pain who underwent abdominal biopsy confirming the presence of adipose inflammation and necrosis. The diagnosis of SM was made, and the patient was treated with prednisone and tamoxifen. As this condition is rare, there are no standard guidelines for management. This case aims to outline a possible treatment plan.

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