Decarboxylative N-Alkylation of Azoles through Visible-Light-Mediated Organophotoredox Catalysis.

An organophotoredox-catalyzed decarboxylative cross-coupling between azole nucleophiles and aliphatic carboxylic acid-derived redox-active esters is demonstrated. This protocol efficiently installs various tertiary or secondary alkyl fragments onto the nitrogen atom of azole nucleophiles under mild and transition-metal-free conditions. The pyridinium additive successfully inhibits the formation of elimination byproducts from the carbocation intermediate. This reaction is applicable to the synthesis of a protein-degrader-like molecule containing an azole and a thalidomide.

Value correlates of collegiate alcohol abuse.

This study tested whether problematic alcohol use correlates with different values clusters in the Schwartz Values Survey. Participants were 156 midwestern university students (M=21.6 yr., 63% women). We used two alcohol-use assessment methods, one involving behavior checklist reports with a questionnaire, the other a two-week daily log procedure. Although exploratory in nature, we took as most important those relationships between alcohol use and values which replicated across both measures. Those who drank frequently and problematically were most likely to endorse a hedonistic and stimulation-seeking values system.