RESUMEN
The study included 104 long-smoking men with COPD. The 10-year risk of osteoporotic fractures was estimated using the FRAX software. It was shown that patients with grade 2 COPD were at minimal risk of fractures of forearm, arm and vertebrae while those with COPD-4 were at maximum risk. The risk of fractures in COPD-2 was significantly different from that in COPD-3 and 4. The 10-year risk of osteoporotic fractures significantly correlated with BMI and DLCO. It is concluded that the use of FRAX makes it possible to reveal patients with COPD at risk of osteoporotic fractures.
Asunto(s)
Fracturas Osteoporóticas/epidemiología , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Anciano , Algoritmos , Humanos , Masculino , Persona de Mediana Edad , Fracturas Osteoporóticas/etiología , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Riesgo , Fumar/efectos adversos , Factores de TiempoRESUMEN
AIM: To study of bone mineral density (BMD) in patients with chronic obstructive pulmonary disease (COPD). SUBJECTS AND METHODS: 104 patients with COPD were examined. A study group comprised men with a long smoking history. BMD of the lumbar spine in the frontal view and that of the proximal femur (the neck, Ward's area, greater trochanter) were studied by dual-energy X-ray absorptiometry using a Lunar DPX-NT densitometer. RESULTS: Osteoporosis of the lumbar spine was most frequently detected in patients with COPD (37.2%). That of the femoral neck was diagnosed in 19.77% of the patients with COPD. In the advanced stage of COPD, the BMD values in all areas were significantly decreased. CONCLUSION: Osteoporosis is a significant disease in patients with COPD.
Asunto(s)
Densidad Ósea/fisiología , Osteoporosis/patología , Enfermedad Pulmonar Obstructiva Crónica/patología , Fumar/patología , Absorciometría de Fotón , Comorbilidad , Cuello Femoral/diagnóstico por imagen , Cuello Femoral/patología , Humanos , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/patología , Masculino , Persona de Mediana Edad , Osteoporosis/complicaciones , Osteoporosis/diagnóstico por imagen , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Fumar/efectos adversos , Fumar/epidemiologíaRESUMEN
Levels of R proteins (RP) and activity of lipid peroxidation (LPO) were measured in 209 patients with RA. It was noted that RP levels and LPO activity correlated with the activity of inflammation. A rapid RA progression was characterized by higher RP levels and LPO activity, while polyarthritis by more intensive RP metabolism and LPO. A comprehensive study of RP and LPO in RA patients may facilitate prognosis of the destruction rate.
Asunto(s)
Artritis Reumatoide/sangre , Proteínas Sanguíneas/metabolismo , Peroxidación de Lípido , Proteínas Sanguíneas/análisis , Progresión de la Enfermedad , Femenino , Pruebas de Inhibición de Hemaglutinación/métodos , Humanos , Mediciones Luminiscentes , Masculino , Persona de Mediana EdadAsunto(s)
Carcinoma de Células Renales/complicaciones , Neoplasias Renales/complicaciones , Hepatopatías/etiología , Síndromes Paraneoplásicos/etiología , Carcinoma de Células Renales/diagnóstico , Diabetes Mellitus/diagnóstico , Diagnóstico Diferencial , Femenino , Humanos , Neoplasias Renales/diagnóstico , Hepatopatías/diagnóstico , Persona de Mediana Edad , Síndromes Paraneoplásicos/diagnósticoRESUMEN
Somatic hybridization was employed for obtaining 335 hybridomas producing monoclonal antibodies to insulin. Twelve hybridomas were cloned by a method of maximum dilutions, and specific immunoglobulins, secreted by them, were characterized by solid phase immunoenzyme assay. Monoclonal antibodies possessed different activity with relation to human, porcine and cattle insulins, indicating their specificity to different epitopes on the insulin molecule. Antibodies of IN-2 and IN-3 clones were capable of inhibiting insulin biological activity in vivo. In experiments on rabbits antibodies of IN-2 clone decreased a 3-fold insulin hypoglycemic action, and antibodies of IN-3 clone caused an increase in the life span of mice after administration of insulin at high doses to them.
