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1.
Br J Neurosurg ; 37(5): 1112-1116, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35924846

RESUMEN

PURPOSE: Symptomatic Chiari type 1 malformation (CIM) patients may elect to be treated; however, choosing the optimum surgical method remains problematic: posterior fossa decompression with duraplasty (PFDD) or without duraplasty (PFD). Many studies have compared these surgical methods from several perspectives. We looked at soft tissue density (STD) at the foramen magnum to add another perspective to the comparison of PFD with PFDD. MATERIALS AND METHODS: Eighty-six patients who underwent surgery in our clinic were included in the study. We examined preoperative and postoperative MR images taken in the 1st year. We obtained the foramen magnum area (FMA) and soft tissue at the level of the foramen magnum. The STD within the foramen magnum was calculated as the percentage ratio of soft tissue area (STA) to FMA. Anteroposterior diameters of the syrinx cavities in sagittal T2 sections were measured preoperatively and at 1-year postoperatively. Measurements were double-blind and were performed by the neurosurgeon and by the neuroradiologist. RESULTS: There was no statistically significant difference between the postoperative FMA increases, STA changes, STD changes in patients who underwent PFD and PFDD. In this study, there was no statistically significant difference between PFD and PFDD in terms of syrinx changes. CONCLUSIONS: The medium-term anatomical outcome following craniovertebral decompression for CIM, is no different whether performed PFD or PFDD.


Asunto(s)
Malformación de Arnold-Chiari , Descompresión Quirúrgica , Humanos , Malformación de Arnold-Chiari/diagnóstico por imagen , Malformación de Arnold-Chiari/cirugía , Descompresión Quirúrgica/métodos , Método Doble Ciego , Duramadre/cirugía , Foramen Magno/cirugía , Estudios Retrospectivos , Resultado del Tratamiento
2.
Br J Neurosurg ; 37(2): 206-212, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-35582922

RESUMEN

PURPOSE: Sellar metastases are rare lesions. Recent improvements in diagnosis and treatment strategies have prolonged survival but increased the probability of metastatic tumors. Evaluation with clinical symptomatology and meticulous laboratory examination is crucial. We present our multicenter national study on sellar metastases to evaluate and underline the main clinical, endocrine, and radiological considerations regarding the diagnosis and endonasal endoscopic management of such rare lesions. METHODS: A medical literature-based retrospective study was planned across 13 neurosurgical centers in Turkey, where a data survey was conducted to collect information regarding sellar metastases surgically treated using the endoscopic endonasal approach, including clinical presentation, radiographic features, primary tumor origin, histopathological confirmation, time to metastasis, treatment, and patient outcomes. RESULTS: Between 2010 and 2020, 54 patients (22 women [40.7%] and 32 men [59.3%]) who underwent surgery with the endonasal endoscopic approach and had pathologically proven sellar metastases (overall incidence, 0.54%) were included. Of the patients, 59.3% had no known malignancy and presented with new-onset symptoms, 79.6% reported headache, 51.9% complained of some degree of visual deficits, and 50% had cranial nerve symptoms. Tissue biopsy was performed in 7.4% of the patients, whereas gross or subtotal resection was achieved in the remaining patients. CONCLUSION: To our knowledge, this is the largest series of patients surgically treated with the endonasal endoscopic approach for sellar metastases. For these patients, the treatment focus should be on management modalities for increasing quality of life instead radical treatment options with survival benefit.


Asunto(s)
Neoplasias Hipofisarias , Calidad de Vida , Masculino , Humanos , Femenino , Estudios Retrospectivos , Resultado del Tratamiento , Nariz/cirugía , Endoscopía , Neoplasias Hipofisarias/cirugía
3.
Turk Neurosurg ; 2023 Oct 19.
Artículo en Inglés | MEDLINE | ID: mdl-39087292

RESUMEN

AIM: Cervical spondylotic myelopathy (CSM) is a common spinal pathology characterized by increased signal intensity (ISI) differences on magnetic resonance imaging, prompting research into its prognostic implications. This retrospective multicenter study aimed to compare the preoperative and postoperative ISI outcomes of CSM patients who underwent posterior decompression and fusion, and to assess the correlation between ISI changes and postsurgical clinical prognosis. MATERIAL AND METHODS: The results from 123 patients were evaluated. In addition to demographic data, such as age and gender, factors, including body mass index (BMI); smoking history; duration of symptoms; follow-up periods; levels of decompression and fusion; comorbidities, such as diabetes, coronary artery disease, and hypertension; ISI grading; cervical sagittal vertical axis; C2-7 cervical lordosis parameters; and Modified Japanese Orthopedic Association (mJOA) scores, were statistically analyzed preoperatively and postoperatively Results: ISI improved in 39 patients (31.7%), remained unchanged in 53 patients (latent, 43.1%), and deteriorated in 31 patients (25.2%). There were no statistically significant differences in terms of age, gender, BMI, or levels of decompression and fusion between patients with ISI improvement, latent ISI, and worsened ISI. Patients with ISI improvement had the highest postoperative C2-7 lordosis values and shortest duration of symptoms. There was no statistically significant difference in the mJOA scores between patients with and without ISI improvement. CONCLUSION: ISI improvement in CSM patients undergoing posterior cervical decompression and fusion is influenced by symptom duration and preoperative-postoperative cervical lordosis values. However, this study did not find a correlation between ISI improvement and clinical recovery based on the mJOA scores.

4.
Turk Neurosurg ; 32(5): 826-833, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35713257

RESUMEN

AIM: To explore the ability of dynamic susceptibility contrast perfusion imaging (DSC-PI) to detect isocitrate dehydrogenase (IDH) gene mutation in gliomas. MATERIAL AND METHODS: Preoperative DSC-PI data on histopathologically proven gliomas obtained between January 2015 and December 2019 were reviewed retrospectively. All magnetic resonance imaging (MRI) examinations were performed using a 1.5-T scanner. The maximum relative cerebral blood volume (rCBVmax), percentage signal recovery (PSR), and normalized PSR of tumor cores were calculated. Differences in these values between IDH-mutant and wild-type gliomas were compared, and receiver operating characteristic curves were generated. RESULTS: The patients (32 females, 47 males) were aged 21-76 years (mean 50.7 ± 15 years). The rCBVmax and all PSR values differed significantly between patients with IDH-mutant and those with wild-type tumors (p < 0.01 for all comparisons). CONCLUSION: The rCBVmax and PSR values obtained by DSC-PI may facilitate noninvasive detection of the IDH mutation status of gliomas. PSR provided more reliable values for differentiation of IDH-mutant gliomas from wild-type gliomas.


Asunto(s)
Neoplasias Encefálicas , Glioma , Adulto , Anciano , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/patología , Femenino , Glioma/diagnóstico por imagen , Glioma/genética , Humanos , Isocitrato Deshidrogenasa/genética , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Mutación , Imagen de Perfusión , Estudios Retrospectivos , Adulto Joven
5.
Turk Neurosurg ; 31(2): 274-281, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33216347

RESUMEN

AIM: To define the natural course of kyphosis, and to evaluate the efficiency of a new technique in surgical correction of kyphosis seen in myelomeningocele(MM) patients. MATERIAL AND METHODS: We retrospectively reviewed our patients with MM. The rate of kyphosis, mean angle of progression and mean angle of surgical correction were evaluated. Surgical correction was achieved with the same technique in all patients; kyphectomy, short segment instrumentation with plate system and long segment instrumentation with screw-rod system. RESULTS: A total of 14 patients were treated surgically and the mean age at the surgery was 39 months. The incidence of kyphosis rate was %21 in this study. The mean angle of kyphosis was 85.8°. Average angle of progression was 15.7° whereas it was 6.3° degree in patients whose kyphosis angle ?90 and > 90 degree, respectively, at birth. 14 patients were treated surgically and the mean age at the surgery was 39 months. The mean angle of correction of kyphosis was 86 degree. The most common complications were wound dehiscence and cerebro-spinal fluid leak. One patient died 3 months after surgery, and one patient was reoperated due to pull-out of screws. CONCLUSION: Effective surgical correction of kyphosis in MM patients can be achieved with the described surgical technique even in younger ages. Prospective studies in larger study population are necessary for more accurate definition of natural history of kyphosis in MM patients.


Asunto(s)
Cifosis/diagnóstico por imagen , Cifosis/cirugía , Meningomielocele/diagnóstico por imagen , Meningomielocele/cirugía , Fusión Vertebral/métodos , Tornillos Óseos/tendencias , Preescolar , Femenino , Humanos , Lactante , Cifosis/etiología , Masculino , Meningomielocele/complicaciones , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/cirugía , Estudios Prospectivos , Reoperación/métodos , Reoperación/tendencias , Estudios Retrospectivos , Fusión Vertebral/tendencias , Resultado del Tratamiento
6.
J Craniofac Surg ; 32(5): 1668-1672, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33201072

RESUMEN

ABSTRACT: Very few studies have focused exclusively on pediatric calvarial tumors. These studies have primarily addressed the similarities of the cases with those reported in the literature, as opposed to their distinctive features. In contrast, the present study is the most detailed study conducted in the last 10 years that includes only pediatric calvarial tumors and highlights their differences according to the literature. A total of 31 patients with pediatric calvarial tumor surgically treated in our center between 2010 and 2020 were included in the study. The patients' files were analyzed retrospectively and 17 different preoperative, intraoperative, and postoperative parameters were determined and compared with previous studies. Except for the tumors causing lytic or sclerotic lesions, there was at least one distinguishing aspect of our series in all parameters. Despite the many distinctive features, the consensus in the treatment of calvarial tumors is to perform complete resection of the tumor and, if possible, remove some of the adjacent healthy bone. Considering the age factor, however, closure of the resulting bone defects with cranioplasty to address issues of cosmesis and intracranial pressure is yet another aspect of pediatric calvarial tumors, because pediatric cranioplasty has its own specific complications. Using intraoperative neuronavigation and performing tumor resection alone without additional craniectomy are also methods the authors use to prevent major bone defects.


Asunto(s)
Neoplasias , Cráneo , Niño , Craneotomía , Humanos , Neuronavegación , Estudios Retrospectivos , Cráneo/cirugía , Resultado del Tratamiento
7.
Turk Neurosurg ; 30(4): 573-576, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32530476

RESUMEN

AIM: To determine the clinical and radiographical aspects of six patients diagnosed with pericallosal lipomas (PCL). MATERIAL AND METHODS: A retrospective analysis of patients who presented to the neurosurgery outpatient clinics of Selcuk Faculty of Medicine between 2009 and 2019, revealed that six patients were diagnosed with PCL. The clinical and magnetic resonance imaging (MRI) data were obtained by reviewing patients? records. RESULTS: A total of six patients (two girls and four boys), with a mean age of 53.8 months (38?72 months), were included in this study. They were followed up for a mean period of 36.5 months (32?41 months). PCL were detected on MRIs, which were obtained to investigate headache in two patients, epilepsy in one patient, frontal dermal sinus tract and left frontal epidermoid tumor in one patient, and subcutaneous lipoma associated with PCL in one patient. Five patients displayed tubulonodular lipomas and one patient displayed curvilinear lipomas. Agenesis or dysgenesis of the corpus callosum (CC) was observed in four (66%) patients. Two patients received surgical treatment for cosmetic skin problem. CONCLUSION: Because of the benign course of PCL, i.e. no growth or very slow growth, and close proximity to the surrounding neurovascular structures, surgical removal should be considered only in symptomatic PCL. Furthermore, other malformations and anomalies may accompany PCL.


Asunto(s)
Neoplasias Encefálicas/diagnóstico por imagen , Cuerpo Calloso/diagnóstico por imagen , Lipoma/diagnóstico por imagen , Neoplasias Encefálicas/cirugía , Niño , Preescolar , Cuerpo Calloso/cirugía , Femenino , Cefalea/diagnóstico por imagen , Cefalea/cirugía , Humanos , Lipoma/cirugía , Imagen por Resonancia Magnética/métodos , Masculino , Estudios Retrospectivos , Tomografía Computarizada por Rayos X/métodos
8.
Turk Neurosurg ; 30(3): 422-427, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32091123

RESUMEN

AIM: To investigate the immunogenetic properties of glial tumors according to the World Health Organization 2016 glial tumor classification and develop an accurate diagnosis and treatment strategy by comparing preoperative advanced magnetic resonance (aMRI) technique findings of these results. MATERIAL AND METHODS: This study was conducted at the Department of Neurosurgery at the Medical Faculty Hospital of Selcuk University between January 1, 2010 and January 4, 2017 and included 50 patients. MR spectroscopy (MRS), MR perfusion (PWI), and MR diffusion (DWI) were performed in 50 patients preoperatively. Patient data were obtained from the hospital’s information system. Pathological diagnosis of all patients was taken from the department of pathology at the same medical faculty. RESULTS: Among the patients included in the study, 11 were grade II (22%), 7 were grade III (14%), and 32 were grade IV (64%). All patients were IDH1 stained: 22 were IDH mutant (44%) and 28 were IDH wild-type (56%). A statistically significant difference in the survival time was observed between IDH mutant and wild-type. IDH-mutant tumors were commonly located in the frontal lobe and IDH wild-type tumors in the parietal and temporal lobes. A significant difference in PWI relative cerebral blood volume (rCBV) and DWI apparent diffusion coefficients (ADC) was noted among grade II, III, and IV tumor groups. The PWI rCBV cut-off value for grade IV tumors was 2.05 (90% sensitivity, 78% specificity). No difference in the Cho/Cr ratio among grade II, III, and IV tumor groups was noted. A significant difference was noted between the IDH mutant and wild type in terms of PWI rCBV. The PWI rCBV cut-off value of IDH mutantâ€"wild type was 2.15. No difference in the Cho/Cr, Cho/NAA, and DWI apparent diffusion coefficients (p > 0.05) was noted between the IDH mutant and wild type. CONCLUSION: PWI rCBV is the most important prognostic value of aMRI used in tumor grading. PWI rCBV values could be significant in distinguishing IDH wild and mutant.


Asunto(s)
Neoplasias Encefálicas/diagnóstico por imagen , Glioma/diagnóstico por imagen , Neuroimagen/métodos , Adulto , Anciano , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/patología , Femenino , Glioma/genética , Glioma/patología , Humanos , Isocitrato Deshidrogenasa/genética , Imagen por Resonancia Magnética/métodos , Espectroscopía de Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Clasificación del Tumor , Sensibilidad y Especificidad
9.
Childs Nerv Syst ; 36(7): 1539-1543, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-31848722

RESUMEN

BACKGROUND: Microcystic meningiomas are extra axial masses that are extremely rare in the pediatric population. Intraventricular meningiomas are also rarely seen. CASE PRESENTATION: This case reports an 18-year-old boy who had an intraventricular mass on magnetic resonance imaging at the age of 12 years and had shown growth at a 6-year follow-up after subtotal resection. The mass was removed by total resection and pathological examination indicated microcystic meningioma. CONCLUSION: The present case is the first pediatric intraventricular microcystic meningioma in the literature. We believe that this unique case presented with its radiological, pathological and clinical features will contribute to the literature.


Asunto(s)
Neoplasias Meníngeas , Meningioma , Adolescente , Humanos , Imagen por Resonancia Magnética , Masculino , Neoplasias Meníngeas/diagnóstico por imagen , Neoplasias Meníngeas/cirugía , Meningioma/diagnóstico por imagen , Meningioma/cirugía , Radiografía
10.
World Neurosurg ; 125: 347-351, 2019 05.
Artículo en Inglés | MEDLINE | ID: mdl-30797924

RESUMEN

BACKGROUND: Vascular injury complications during lumbar discectomy are rare but potentially life-threatening. Therefore, an early diagnosis and effective treatment management is required for these complications. CASE DESCRIPTION: A 50-year-old female patient was admitted to our outpatient clinic with severe back and right leg pain. She underwent surgery for right L4-5 extruded disc herniation with general anesthesia. Sudden arterial hemorrhage occurred during discectomy performed with straight disc forceps and was controlled using hemostatic materials, with no significant decrease in blood pressure. However, the patient became hypotensive near the end of the operation. The incision was quickly closed, and she was turned to supine position. Emergency abdominal ultrasound, computed tomography, and computed tomography angiography revealed an injury of the left main iliac artery, which was repaired by endovascular stenting. Laparotomy and Bogota bag were applied because of increased intrabdominal pressure at 3 hours postoperative. In addition, a retroperitoneal catheter was placed into the area of the right retroperitoneal hematoma on the first postoperative day. Tissue plasminogen activator was administered through the catheter. On postoperative day 3, the Bogota bag was removed, and the abdomen was closed. The patient was discharged without neurodeficit on day 27. Her abdominal fascial defect was closed with a synthetic graft after 5 months. CONCLUSIONS: Although lumbar discectomy is one of the most commonly performed neurosurgical procedures, the routine rules of discectomy should not be neglected. Early detection and a multidisciplinary approach can help prevent mortality in the event of vascular injury.


Asunto(s)
Discectomía/efectos adversos , Arteria Ilíaca/lesiones , Desplazamiento del Disco Intervertebral/cirugía , Vértebras Lumbares/cirugía , Pérdida de Sangre Quirúrgica , Angiografía por Tomografía Computarizada , Diagnóstico Precoz , Femenino , Fibrinolíticos/administración & dosificación , Humanos , Arteria Ilíaca/diagnóstico por imagen , Complicaciones Intraoperatorias/etiología , Persona de Mediana Edad , Imagen Multimodal , Stents , Activador de Tejido Plasminógeno/administración & dosificación , Ultrasonografía , Lesiones del Sistema Vascular/diagnóstico por imagen
11.
World Neurosurg ; 124: 410-413, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30703595

RESUMEN

We described the imaging findings of small cell lung carcinoma metastasis to atypical meningioma and the importance of magnetic resonance imaging perfusion graphics at the differential diagnosis. To be able to determine subtypes of meningiomas and differentiate whether they are malignant or benign may provide a preoperative idea to determine prognosis and surgical procedure.

12.
Asian J Surg ; 40(2): 166-170, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24650725

RESUMEN

Cerebellar mutism is a transient period of speechlessness that evolves after posterior fossa surgery in children. Although direct cerebellar and brain stem injury and supratentorial dysfunction have been implicated in the mediation of mutism, the pathophysiological mechanisms involved in the evolution of this kind of mutism remain unclear. Magnetic resonance imaging revealed dentatothalamocortical tract injuries and single photon emission computed tomography showed cerebellar and cerebral hypoperfusion in patients with cerebellar mutism. However, findings with 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in this group of patients have not been documented previously. In this clinical case, we report a patient who experienced cerebellar mutism after undergoing a posterior fossa surgery. Right cerebellar and left frontal lobe hypometabolism was shown using FDG PET/CT. The FDG metabolism of both the cerebellum and the frontal lobe returned to normal levels after the resolution of the mutism symptoms.


Asunto(s)
Quistes Aracnoideos/diagnóstico por imagen , Neoplasias Cerebelosas/diagnóstico por imagen , Neoplasias Cerebelosas/cirugía , Fosa Craneal Posterior/cirugía , Mutismo/etiología , Procedimientos Neuroquirúrgicos/efectos adversos , Adolescente , Quistes Aracnoideos/cirugía , Fosa Craneal Posterior/diagnóstico por imagen , Fosa Craneal Posterior/patología , Fluorodesoxiglucosa F18 , Estudios de Seguimiento , Humanos , Masculino , Monitoreo Fisiológico/métodos , Mutismo/fisiopatología , Procedimientos Neuroquirúrgicos/métodos , Tomografía Computarizada por Tomografía de Emisión de Positrones , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/fisiopatología , Remisión Espontánea , Factores de Tiempo
13.
Asian J Surg ; 40(3): 240-242, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-24938858

RESUMEN

Intramedullary schwannomas of the spinal cord are rare tumors. They are most commonly observed in the cervical region; however, few have been described in the conus medullaris. The association of intramedullary schwannomas with syringomyelia is also rare. In this report, we present a case of intramedullary schwannoma of the conus medullaris with syringomyelia, which was treated surgically.


Asunto(s)
Neurilemoma/complicaciones , Neurilemoma/diagnóstico por imagen , Neoplasias de la Médula Espinal/complicaciones , Neoplasias de la Médula Espinal/diagnóstico por imagen , Siringomielia/complicaciones , Siringomielia/diagnóstico por imagen , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética , Neurilemoma/cirugía , Neoplasias de la Médula Espinal/cirugía , Siringomielia/cirugía
14.
J Neurol Surg A Cent Eur Neurosurg ; 77(3): 201-6, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-25915497

RESUMEN

BACKGROUND The aim of this study was to assess the usability of an electrocautery device as nerve stimulator and to investigate histopathologically the adverse effects of electrocautery at low power on rat sciatic nerves. METHODS A total of 36 female Sprague-Dawley albino rats were divided into six groups according to the power applied to their sciatic nerves (1, 2, 3, 4, 5 and 6 W, respectively). Pathologic changes were studied by microscopic examination and scored (no change = 0, mild = 1, moderate = 2, severe = 3). Multiple comparisons were provided for all groups by the Bonferroni test (one-way analysis of variance). A p value < 0.05 was accepted as statistically significant. RESULTS The average scores were 2.66 ± 0.51, 3.66 ± 0.51, 5.83 ± 1.83, 10.0 ± 1.78, 11.0 ± 1.54, and 13.8 ± 0.89 in groups 1 to 6, respectively. Significant differences were found between all groups (p < 0.01), except between groups 1 and 2, groups 2 and 3, and groups 4 and 5 (p > 0.05) Variable motor responses and foot deformities were observed at the different power levels. CONCLUSION Although electrocautery devices provoke motor responses if getting in contact with peripheral nerves as do nerve stimulators, their use induces histopathologically adverse effects even at the lowest power. Their use around peripheral nerves should be avoided.


Asunto(s)
Electrocoagulación/efectos adversos , Deformidades Adquiridas del Pie/etiología , Nervio Ciático/patología , Nervio Ciático/fisiología , Animales , Femenino , Deformidades Adquiridas del Pie/patología , Deformidades Adquiridas del Pie/fisiopatología , Ratas , Ratas Sprague-Dawley
15.
Turk Neurosurg ; 25(5): 801-3, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26442551

RESUMEN

Colloid cysts are the most common third ventricle lesions and metastasis to this area is rare. We presented a case of solitary metastasis from a renal cell carcinoma to the third ventricle choroid plexus mimicking a colloid cyst. A 53-year-old man, who had a history of renal cell carcinoma 12 years ago, was operated for single third ventricle lesion and hydrocephalus via a transcallosal approach. Total removal could not be performed due to intraoperative massive bleeding. Histological examination revealed a metastatic renal cell carcinoma. The patient died on the postoperative 13th day because of bleeding from the residual tumor. Stereotactic radiosurgery and ventriculoperitoneal shunting might be favorable in such cases in order to avoid serious complications.


Asunto(s)
Carcinoma de Células Renales/secundario , Neoplasias del Ventrículo Cerebral/secundario , Diagnóstico Diferencial , Neoplasias Renales/patología , Tercer Ventrículo/patología , Quiste Coloide/patología , Humanos , Masculino , Persona de Mediana Edad
16.
Turk Neurosurg ; 25(2): 337-9, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26014025

RESUMEN

Tuberculomas are small tumor-like lumps that can be seen, usually in large numbers, in central nervous system involvement of tuberculosis. Giant tuberculomas that are big enough to cause symptoms of compression are also encountered, though rarely. When they are really large, tuberculomas may result in increased intracranial compression, neurologic deficits, or epileptic attacks. Giant tuberculomas may be confused with brain tumors on cranial magnetic resonance imaging. Cranial magnetic resonance imaging and histopathology examinations are used for diagnosis. Although magnetic resonance imaging is useful for diagnosing tuberculoma, histopathology examination is the gold standard for a final diagnosis. This paper presents a case involving a 66-year-old patient who complained of headache, imbalance and dizziness, and underwent an operation in the neurosurgery clinic with a pre-diagnosis of brain tumor, and was then diagnosed with intracranial giant tuberculoma.


Asunto(s)
Antituberculosos/uso terapéutico , Neoplasias Encefálicas/diagnóstico , Tuberculoma Intracraneal/diagnóstico , Tuberculoma Intracraneal/tratamiento farmacológico , Anciano , Neoplasias Encefálicas/complicaciones , Diagnóstico Diferencial , Epilepsia/diagnóstico , Epilepsia/tratamiento farmacológico , Epilepsia/etiología , Cefalea/diagnóstico , Cefalea/tratamiento farmacológico , Cefalea/etiología , Humanos , Masculino , Tuberculoma Intracraneal/complicaciones
17.
J Neurosurg Spine ; 22(6): 596-604, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25815805

RESUMEN

OBJECT Due to lack of construct stability of the current anterior cervical approaches, supplemental posterior cervical approaches are frequently employed. The use of an anterior-only approach with anterior transpedicular screws (ATPSs) has been proposed as a means of providing 3-column fixation. This study was designed to investigate the feasibility of anterior transpedicular screw (ATPS) fixation of cervical spine, to obtain the morphological measurements for technical prerequisites, and to evaluate the accuracy of the ATPS using fluoroscopy. METHODS The study included both radiological and anatomical investigations. The radiological investigations were based on data from cervical spine CT scans performed in 65 patients. Technical prerequisites of ATPS were calculated using OsiriX for Mac OS. In the anatomical part of the study, 30 pedicles (C3-7) from 6 formalin-preserved cadavers were manually instrumented. Measurements obtained included pedicle width (PW), pedicle height (PH), pedicle transverse angle (PTA), distance of the entry point from the midline (DEPM), and distance of the entry point from the superior endplate (DEPSEP). The authors also analyzed screw position in the manually instrumented vertebrae. RESULTS The mean PW and PH values showed a tendency to increase from C-3 to C-7 in both males and females. The means were significantly larger for both PW and PH in males than in females at all levels (p = 0.001). The overall mean PTA value was significantly lower at C-7 (p < 0.0001). The mean value for the distance of entry point from the midline (DEPM) represented a point at the contralateral side of the pedicle for every level except C-7. The mean DEPSEP values showed significant differences between all levels (p < 0.0001). Seven of the 30 screws were identified as breaching the pedicle (23.3%); these screw malplacements were seen at C-3 (3 screws), C-4 (2 screws), and C-5 (2 screws). CONCLUSIONS The morphological measurements of this study demonstrated that ATPS fixation is feasible in selected cases. They indicate that ATPS insertion using a fluoroscopy-assisted pedicle axis view is safe at the C-6 and C-7 levels, but the results at the other levels did not prove the safety of this technique.


Asunto(s)
Tornillos Óseos , Vértebras Cervicales/patología , Vértebras Cervicales/cirugía , Fijadores Internos , Procedimientos Ortopédicos , Adulto , Anciano , Tornillos Óseos/efectos adversos , Cadáver , Estudios de Factibilidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Ortopédicos/métodos , Tomografía Computarizada por Rayos X/métodos , Resultado del Tratamiento , Adulto Joven
18.
J Craniofac Surg ; 26(1): e39-42, 2015 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25565240

RESUMEN

The surgical management of giant pituitary adenomas is challenging. Although most pituitary adenomas, even those with suprasellar extension, can be resected using the transsphenoidal surgery alone, the transcranial approach is still needed for approximately 1% to 4% of these tumors. The transcranial approach is usually used in large adenomas with hourglass configuration and adenomas with firm consistency impeding the adjunctive measures, which are used for delivering the suprasellar part of the tumor into the sellar area and thereby obscure the tumor resection by transsphenoidal route. In this report, we describe the successful use of transventricular endoscope as an adjunctive measure to remove giant pituitary adenoma from transsphenoidal route and discuss the limitations of this new technique. We concluded that this technique would be used safely in selected cases. Case selection and surgical strategies should be based on preoperative magnetic resonance imaging findings, ventricular size, and the availability of experienced surgeons.


Asunto(s)
Adenoma/cirugía , Hidrocefalia/cirugía , Neoplasias Hipofisarias/cirugía , Adenoma/complicaciones , Ventrículos Cerebrales/cirugía , Craneotomía/métodos , Endoscopía/métodos , Femenino , Estudios de Seguimiento , Humanos , Hidrocefalia/etiología , Imagen por Resonancia Magnética/métodos , Persona de Mediana Edad , Invasividad Neoplásica , Procedimientos Neuroquirúrgicos/métodos , Planificación de Atención al Paciente , Selección de Paciente , Neoplasias Hipofisarias/complicaciones , Hueso Esfenoides/cirugía
19.
J Neurosurg ; 120(6): 1465-70, 2014 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24678778

RESUMEN

OBJECT: In this study the authors compare the efficacy of endoscopic third ventriculostomy (ETV) versus CSF shunting for resolution of papilledema in hydrocephalus. METHODS: This comparative case series study recruited 12 patients (24 eyes) with hydrocephalus who underwent either an ETV (Group 1, 6 patients [12 eyes]) or CSF shunt treatment (Group 2, 6 patients [12 eyes]). A complete ophthalmological examination including retinal nerve fiber layer (RNFL) evaluation by optical coherence tomography was provided for all patients before surgery and in the 1st week, 1st month, and 3rd month postoperatively. The 2 groups were compared for quantitative changes in RNFL thickness and, thereby, resolution of papilledema. Statistical evaluation was performed using the Mann-Whitney U-test with the aid of SPSS version 16.0. RESULTS: The mean preoperative RNFL thickness was 259.7 ± 35.8 µm in Group 1 and 244.5 ± 53.4 µm in Group 2 (p = 0.798). The mean decrease in RNFL thickness was 101.3 ± 38.8 µm, 141.2 ± 34.6 µm, and 162.0 ± 35.9 µm in Group 1 versus 97.0 ± 44.6 µm, 143 ± 45.6 µm, and 130.0 ± 59.8 µm in Group 2 for the postoperative 1st week, 1st month, and 3rd month, respectively. There was no significant difference between the two groups with respect to decrease in RNFL thickness during the 1st week, 1st month, and 3rd month (p = 0.563, p = 0.753, and p = 0.528, respectively). CONCLUSIONS: This is the first study to quantitatively evaluate papilledema in assessing the success of ETV and CSF shunting. The authors' results indicated that ETV is as effective as CSF shunting with respect to decreasing intracranial pressure and resolution of papilledema.


Asunto(s)
Derivaciones del Líquido Cefalorraquídeo , Endoscopía/métodos , Hidrocefalia/cirugía , Procedimientos Neuroquirúrgicos/métodos , Papiledema/epidemiología , Tercer Ventrículo/cirugía , Ventriculostomía , Adolescente , Adulto , Femenino , Humanos , Hidrocefalia/complicaciones , Hidrocefalia/fisiopatología , Incidencia , Presión Intracraneal/fisiología , Masculino , Persona de Mediana Edad , Nervio Óptico/fisiopatología , Papiledema/etiología , Papiledema/fisiopatología , Estudios Prospectivos , Tomografía de Coherencia Óptica , Resultado del Tratamiento , Adulto Joven
20.
Spine J ; 14(8): 1702-8, 2014 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-24704680

RESUMEN

BACKGROUND CONTEXT: We retrospectively analyzed a total of 1,218 pedicle screws for accuracy, with postoperative computed tomography (CT), in 198 patients who were operated on between March 2004 and September 2012. PURPOSE: To determine the incidence of screw misplacement in patients who received a transpedicular screw fixation, with intraoperative fluoroscopy in the lateral and lateral with anteroposterior (AP) positions. The results are compared between the two groups. STUDY DESIGN: Retrospective comparative study of accuracy of pedicle screw placement in thoracic and lumbar spine. PATIENT SAMPLE: The sample consists of 198 consecutive patients who underwent transpedicular screw fixation. OUTCOME MEASURES: Accuracy of screw placement was evaluated by postoperative CT scan. Misplacement was defined in cases where more than 25% of the screw size was residing outside the pedicle. METHODS: The indications for hardware placement, radiologic studies, patient demographics, and reoperation rates were recorded. Five hundred twenty-eight screws (Group A, n=81) were inserted into the vertebral body with the assistance of lateral fluoroscopy only, whereas 690 screws (Group B, n=117) were inserted with the assistance of lateral fluoroscopy, and the final positions of the screws were checked with AP fluoroscopy. RESULTS: A total of 1,218 screws were analyzed, with 962 screws placed at the lumbosacral region and 256 screws at the thoracic region. According to the postoperative CT scan, 27 screws (2.2%) were identified as breaching the pedicle. Nineteen of them (3.6%) were in Group A, whereas 8 (1.16%) were in Group B. The rate of pedicle breaches was significantly different between Group A and B (p=.0052). In Group A, the lateral violation of the pedicle was seen in 10 screws (1.9%), whereas medial violation was seen in 9 screws (1.7%). In Group B, the lateral violation of the pedicle was seen in six screws (0.87%), whereas medial violation was seen in two screws (0.29%). The medial and lateral penetration of screws were significantly different between Groups A and B (p<.05). A pedicle breach occurred in 21 patients, and 15 of them underwent a revision surgery to correct the misplaced screw. Of these patients, 11 (13.6%) were in Group A, and 4 (3.4%) were in Group B (p=.0335). CONCLUSIONS: In this study, we evaluated and clarified the diagnostic value of intraoperative fluoroscopy in both the lateral and AP imaging that have not yet been evaluated in any comparative study. We concluded that the intraoperative use of fluoroscopy, especially in the AP position, significantly decreases the risk of screw misplacement and the results are comparable with other advanced techniques.


Asunto(s)
Fluoroscopía/métodos , Vértebras Lumbares/cirugía , Tornillos Pediculares , Enfermedades de la Columna Vertebral/cirugía , Fusión Vertebral/instrumentación , Columna Vertebral/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Reoperación , Estudios Retrospectivos , Resultado del Tratamiento , Adulto Joven
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