The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review.

This narrative review summarizes current knowledge on the effects of physical activity (PA) on adipokine levels in individuals with overweight and obesity. Approximately 90 investigations including randomized control, cross-sectional and longitudinal studies that reported on the effects of a single session of PA (acute) or long-term PA (chronic) on adipokine levels in individuals with overweight/obesity were reviewed. The findings support the notion that there is consensus on the benefits of chronic exercise training-regardless of the mode (resistance vs. aerobic), intensity and cohort (healthy vs. diabetes)-on adipokine levels (such as tumour necrosis factor-alpha, interleukin-6, adiponectin, visfatin, omentin-1 and leptin). However, several confounding factors (frequency, intensity, time and type of exercise) can alter the magnitude of the effects of an acute exercise session. Available evidence suggests that PA, as a part of routine lifestyle behaviour, improves obesity complications by modulating adipokine levels. However, additional research is needed to help identify the most effective interventions to elicit the most beneficial changes in adipokine levels in individuals with overweight/obesity.

Exercise training prevents high-fat diet-induced adipose tissue remodeling by promoting capillary density and macrophage polarization.

AIMS: Increasing adipose tissue capillarization is beneficial to metabolic health. The present study examined the effects of continuous training (CT) and aerobic-interval training (AIT) coinciding with a high-fat diet (HFD) on capillary density, macrophage polarization in mesenteric (mAT) and subcutaneous (sAT) adipose tissue. MAIN METHODS: 48 male Wistar rats were divided into HFD and normal diet (ND) groups. After 10 weeks, each group was divided into sedentary, CT, and AIT. The animals in training groups performed 10-week matched distances of CT and AIT on a motorized treadmill (5 times/week). KEY FINDINGS: The results showed that HFD significantly reduced the capillary density of adipose tissue (sAT: 54% vs. mAT:49%) and increased systemic insulin resistance, mean adipocyte size, crown-like structure (CLs), and M1-macrophages with no change in the total number of adipocytes in either tissue. Exercise training reversed the HFD induced adipose tissue dysfunction. Compared to CT, AIT was more effective on increasing the capillary density of sAT (170 vs. 87%) and mAT (140 vs. 100%). Likewise, AIT increased the capillary density of both tissues even in comparison to the ND sedentary group (~25%). Compared with CT as well, AIT more significantly increased the number of M2 macrophages (181 vs. 122%) and decreased CLs (60 vs. 38%) in mAT. SIGNIFICANCE: The findings suggest that hypertrophy is a major contributor to adipose tissue expansion in obesity. Furthermore, exercise training largely demonstrated beneficial effects on adipose tissue remodeling, where AIT is more effective than CT in reducing HFD-induced adipose tissue dysfunction.

Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men.

BACKGROUND: Circuit resistance training (CRT) is a time-efficient exercise modality for improving skeletal muscle and cardiovascular fitness. But the beneficial role of CRT in obese individuals is still not well understood. This study explores the reducing effects of progressive CRT on inflammatory biomarkers and cardiometabolic risk factors in obese young men. METHODS: Thirty obese men (Body mass index (BMI): 30.67 ±â€¯3.06; age: 23 ±â€¯3.2 years) were divided into CRT and control groups. The CRT was performed for eight-weeks (3 times/week, 65-85% of 1 repetition maximum). Fasting blood samples were taken pre and post intervention for analyzing apelin, chemerin, serum amyloid A (SAA), C reactive protein concentrations (CRP), lipid profile, and insulin resistance index. The data were assessed by two-way repeated measures ANOVA. RESULTS: Body mass, BMI and waist to hip ratio (WHR) were significantly decreased after training intervention (P < .05). Compared to the control group, the plasma concentrations of Chemrin (P = .038), SAA (P = .004), insulin (P < .001), insulin resistance index (P < .001), total cholesterol (P = .033), triglyceride (P < .001), and low-density lipoprotein (P = .039), were significantly mitigated in the CRT group, but high-density lipoprotein plasma levels increased in the CRT group compared to that of the control group (P = .035). There was no significant difference between two groups in apelin and CRP (P > .05). Moreover, insulin resistance was positively correlated with apelin (r = 0.56) and chemerin (r = 0.51). Also, chemerin had a positive correlation with SAA (r = 0.49), and WHR (r = 0.54). CONCLUSION: CRT caused an improvement in inflammation and cardiometabolic risk factors in young obese men, and this improvement was accompanied by decreased insulin resistance.