RESUMEN
We estimated the efficacy of Brizantin preparation in suppressing nicotine dependence in rats. It was shown that nicotine-dependent rats in the situation of choice between the chamber with smoke or the chamber with food more frequently entered the chamber with tobacco smoke and stayed there longer. The rats that received Brizantin demonstrated significantly fewer visits to the chamber with smoke and spent there less time. Reduced locomotor activity and orientation and exploratory behavior in rats against the background of Brizantin administration also suggest reduced motivation for smoke inhalation. Thus, Brizantin effectively diminished nicotine dependence in rats in the model of nicotine addiction.
Asunto(s)
Anticuerpos/uso terapéutico , Conducta de Elección/efectos de los fármacos , Combinación de Medicamentos , Conducta Exploratoria/efectos de los fármacos , Tabaquismo/tratamiento farmacológico , Animales , Privación de Alimentos , Hambre , Masculino , Motivación , Nicotina , Ratas , Autoadministración , Humo , Fumar/tratamiento farmacológico , NicotianaRESUMEN
We studied the effect of potentiated antibodies to morphine (10(-100) wt %) on self-stimulation of the lateral hypothalamus and behavioral reactions reflecting the severity of withdrawal syndrome in rats with morphine dependence. Repeated treatment with potentiated antibodies to morphine increased the rate of self-stimulation, suppressed active avoidance response, promoted freezing behavior after acoustic stimulation, and decreased tail-flick latency in rats after morphine withdrawal. Distilled water did not produce these changes.
