Chronic Ethanol Consumption by Rats before Mating Affects Working Memory in the Offspring.

Parameters of non-spatial and spatial memory were evaluated in sexually mature offspring of outbred rats (females and males F0) consuming a 10% ethanol solution for 30 weeks before mating. We found a significant increase in the recognition index in F1 males and its decrease in F1 females in the novel object recognition test. During the first days of the experiment in T-maze, a decrease in spatial memory was revealed in F1 males, which remained at the trend level until the end of testing; no significant deviations were detected in F1 females. Memory impairment in F1 females was accompanied by a decrease in BDNF level in the hippocampus, but not in the prefrontal cortex. Thus, ethanol consumption by F0 rats before mating led to impairment of long-term working memory only in female F1 offspring.

[Method of determination of ecologically induced actual risk for human health and the degree of stress in medical and ecological situations]. / Metodika opredeleniia ékologicheski obuslovlennogo real'nogo riska zdorov'iu liudei i stepeni napriazhennosti mediko-ékologicheskoi situatsii.

Lipetsk town area was ranked according to maximal or minimal actual risk for public health (with consideration of medical and ecologic situation if influenced by technogenic hazards. That ranking enables to suggest municipal measures aimed at protection of population of ecologic hazards.