RESUMEN
AIM: To optimize the transurethral endoscopic management of patients with ureterolithiasis by measuring biomarkers of renal parenchymal damage. MATERIALS AND METHODS: One hundred fifty-one patients with solitary ureteral stones were tested for levels of cystatin C, neutrophil gelatinase-associated lipocalin, 2-microglobulin and interleukin 18. RESULTS: An increase in the levels of markers of renal injury was observed both in the preoperative period and after CULT. Differences in the values of these indices depended on the timing of the CULT, the size and location of the stone and the type of lithotripter. CONCLUSIONS: All patients were found to have damage to the renal tubular system. The established critical values of the markers of renal injury in ureterolithiasis may be used as diagnostic criteria for renal injury.
Asunto(s)
Cistatina C/sangre , Gelatinasas/sangre , Interleucina-18/sangre , Lipocalinas/sangre , Litotricia , Ureterolitiasis , Microglobulina beta-2/sangre , Biomarcadores/sangre , Femenino , Humanos , Masculino , Ureterolitiasis/sangre , Ureterolitiasis/terapiaRESUMEN
The article outlines the experience with radical surgical treatment of muscle-invasive bladder cancer in two patients with dialysis-dependent end-stage chronic kidney disease. The authors describe diagnosis and surgical technique in this category of patients.
Asunto(s)
Fallo Renal Crónico/complicaciones , Músculo Liso/patología , Neoplasias de la Vejiga Urinaria/patología , Neoplasias de la Vejiga Urinaria/terapia , Anciano , Cistectomía , Femenino , Humanos , Invasividad Neoplásica , Resultado del Tratamiento , Neoplasias de la Vejiga Urinaria/complicacionesRESUMEN
The comparative analysis of changes of the functional (osmolar clearance and fractional excretion of urea) and structural (NGAL, ß2-microglobulin in the blood plasma, and NGAL, ß2-microglobulin, microalbumin in the urine) biomarkers of kidney damage before and at various stages after radical cystectomy was performed. The study included patients with T2N0M0 stage bladder cancer. The main group consisted of 37 patients receiving nephroprotective treatment (N-acetylcysteine), the comparison group--31 patients receiving background therapy. It was revealed that severity of kidney dysfunction and the incidence of chronic kidney disease in the long-term period after surgery decreased in the main group.
