RESUMEN
A formal thio [3 + 3]-cyclization catalyzed by a DPEN-derived chiral thiourea has been reported for the construction of optically active thiopyrano-indole annulated heterocyclic compounds in high yields with excellent enantioselectivities. The high reactivity between indoline-2-thione (keto-S) and 2-benzylidenemalononitrile has also been supported by density functional theory (DFT) calculations.
Asunto(s)
Compuestos Heterocíclicos de 4 o más Anillos/síntesis química , Indoles/química , Ciclización , Etilenodiaminas/química , Compuestos Heterocíclicos de 4 o más Anillos/química , Estereoisomerismo , Tiourea/químicaRESUMEN
Enantioselective phosphination and hydrophosphonylation reactions between azomethine imines and diarylphosphine oxides or dialkyl phosphites were respectively developed by the use of a chiral squaramide as the hydrogen bonding organocatalyst, which afforded two types of phosphorus containing product in high yields with good to excellent enantioselectivities.