Nomenclature in Palliative Surgery.

Surgical palliative care, palliative care interventions, and palliative surgery all reference a blend of these 2 sub-specialty fields. Despite prior published definitions, use of these phrases both clinically and in the literature is varied and can lead to confusion and misunderstanding. Herein, we proposed the adoption of standardized nomenclature to guide the consistent use of these phrases.

Palliative care interventions for surgical patients: a narrative review.

BACKGROUND AND OBJECTIVE: Palliative interventions have known benefits in the care of surgical patients with advanced illness. However, the literature supporting the routine use and implementation of palliative care in the context of surgery is limited. The primary aim of this review was to explore the literature that has been published in the field of surgical palliative care since 2016. The secondary aim of this analysis was to categorize updates in literature in three foundational domains (I) measuring outcomes that matter to patients; (II) communication and decision making; and (III) delivery of palliative care to surgical patients. METHODS: This analysis included citations from PubMed, EMBASE, PsychINFO, and CINAHL, circulated between 01/01/2016 and 22/02/2022 that studied palliative care interventions for surgical patients. Additional articles were included following a manual review of citations and publications from the Annals of Palliative Medicine. KEY CONTENT AND FINDINGS: A total of 3,258 unique articles were identified through the database search, and eight additional studies were identified from manual review. Twenty-two articles were included in the final narrative review: seven addressed the first foundational domain, three explored the second, and twelve summarized developments in the third. CONCLUSIONS: With advances in clinical opportunities to support seriously ill patients, the adoption of palliative care frameworks in surgical settings is essential to achieving value-concordant care. Though the literature studying the delivery of palliative care for surgical patients is slowly expanding, additional work is needed to optimize pre and post-operative patient engagement in complex decision making, align surgical treatments with patient-oriented outcomes, and integrate palliative care principles into routine surgical practice.

Primary palliative care for surgeons: a narrative review and synthesis of core competencies.

The practice of palliative medicine has grown substantially over the last two decades and the data demonstrates that seriously ill and injured surgical patients as well as their loved one's benefit from the integration of palliative care into standard surgical management. This narrative review highlights the patient and family benefit of primary surgical palliative care (PSPC) for seriously ill or injured surgical patients and the need for primary palliative care (PPC) skill acquisition by surgeons. The review encourages surgeons to identify all aspects of suffering as a critical component of the care needs of surgical patients and families and to consider integrating mitigation strategies during surgical care. Identification of suffering has not been traditionally taught in surgical training or reinforced in surgical practice, therefore current surgical educational opportunities should incorporate such instruction to assist surgeons in training and in practice to acknowledge and treat suffering to improve and expand the quality and value of surgical care offered to seriously ill or injured surgical patients. Additionally, a patient-centered approach to surgical care necessitates engaging advanced communication skills to successfully ascertain a patient's and/or their surrogate decision maker's, substituted goals and values in the provision of surgical care to ensure that all the care delivered is aligned with each patient's preferences. A preliminary synthesis of core competencies to achieve these SPC objectives is presented.

Palliative interventions for patients with advanced gastric cancer: a systematic review.

BACKGROUND: Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Advanced gastric cancer (AGC) is associated with significant morbidity and mortality and is commonly accompanied by a variety of distressing symptoms. Current National Comprehensive Cancer Network (NCCN) guidelines recommend palliative treatment modalities for patients with AGC and the treatment of AGC patients should be influenced by palliative care principles. The objective of this systematic review was to explore the published literature on palliative interventions for patients with AGC. METHODS: We performed a systematic literature search to identify English language studies that investigated interventions to improve or treat the symptoms caused by AGC using PubMed, Embase, and Cochrane Library databases from January 1, 2010 to August 18, 2022. Two independent reviewers performed title and abstract review, followed by full-text review and data abstraction. Overall study quality and risk of bias was assessed using published quality assessment tools. RESULTS: We identified 10,364 studies and included 66 studies published between 2010 and 2022 for final review. Among the studies, quality of life (QoL) metrics were most commonly a secondary outcome. Twenty-three studies addressed the palliative management of bleeding with the use of radiation therapy, surgery, arterial embolization, chemotherapy, or endoscopic interventions. Twenty-two studies addressed the management of obstructive symptoms with endoscopic stenting or surgical interventions. Most of these studies were of moderate quality and included well characterized outcomes focused on symptom reduction. Five studies assessed palliative modalities to reduce the symptomatic burden of intraabdominal ascites; these studies were less well characterized, and on average low quality. Fifteen studies of mixed quality assessed QoL for patients with AGC, with only one study evaluating specialty palliative care consultation. No studies outlined the prevalence or practices of advanced care planning in this patient population. CONCLUSIONS: Patients with AGC undergo a variety of interventions aimed at palliating the symptoms associated with their diagnosis and improving their QoL. Future research on palliative interventions for patients with AGC should utilize qualitative methodologies to measure outcomes related to symptom management and QoL, further explore the patient experience of living with AGC, and delineate best practices for advanced care planning in this population.

Strategies for Collaborative Consideration of Patients' Resuscitation Preferences.

Procedural treatment teams encounter patients with preoperative do-not-resuscitate (DNR) orders who are seeking procedural interventions to improve their quality of life. Required reconsideration is the professional discussion standard that seeks to engage patients or their surrogate decision makers in revisiting patient preferences for rescinding or maintaining a DNR order perioperatively. This article canvasses features of a required reconsideration discussion and guidelines for adhering to this standard.

The Empathy Project: A Skills-Development Game: Innovations in Empathy Development.

CONTEXT: Empathy is increasingly described as a learnable skill and is included in professionalism requirements for health care providers, yet there are few effective tools for developing and practicing empathy skills. INNOVATION: An educational innovation intended to isolate and develop skills to respond to patients' emotions. The game-based tool was developed on the job during the authors' Hospice and Palliative Medicine fellowship year and was played with learners in various disciplines. OUTCOMES: Feedback from learners was overwhelmingly positive, although a key factor in optimization of learning was the presence of a communication expert as facilitator. Learner responses were measured using a novel assessment tool, and findings suggest statistically significant expansion of language and intent to express empathy. Learners demonstrated immediate growth in naming emotions, reflecting understanding and respect of emotional expression, and supporting and exploring emotional content. COMMENT: This innovative game-based learning tool is of low cost and feasible to deploy. It could be easily incorporated into medical education curricula aimed at developing communication skills, especially the skill of responding to emotion with empathy. Future research is needed to assess the effects the innovation has on behavior as well as its impact on patient-centered outcomes.

Discussing Prognosis and Shared Decision-Making.

When making high-stakes decisions with their patients, surgeons may have only one opportunity to get a life-changing conversation right. These loaded conversations cover immense ground. Bad news, emotion, prognosis, treatment choices, and patient goals all play a part in coming up with the right plan for each individual patient. Surgeons and patients may overlook important factors when the language and process of informed consent is substituted for decision-making. "Best Case/Worst Case" is a communication tool based in scenario planning that promotes shared decision-making in high-stakes surgical conversations and is discussed at length in this review.

Surgery Hurts: Characterizing the Experience of Pain in Surgical Patients as Witnessed by Medical Students.

BACKGROUND: The patient experience around surgical care is poorly characterized. Medical students have a unique position on the surgical team, which allows them to observe patient experiences that may otherwise be overlooked. The objective of this study was to characterize surgical patients' experience with pain as witnessed by medical students. STUDY DESIGN: At the end of an 8-week surgical clerkship, we asked all third-year medical students to write a reflective essay describing one surgical patient in pain. We collected 341 essays over a 4-year period and used qualitative content analysis to explore the students' reports of pain experienced by surgical patients. RESULTS: When asked to tell a story about a surgical patient in pain, medical students report vivid descriptions of physical agony, emotional distress, and patient regret. For example, "Throughout the procedure our patient cried out and writhed in agony from the searing pain in his chest," and "The patient was practically shedding tears, complaining of pain, as [we] changed her dressing." The students' accounts reveal wide-ranging physical and emotional suffering among surgical patients, including alterations in self-image and feelings of vulnerability. Pain and suffering were intensified when patients felt they had lost control, in settings of uncertain prognosis and with unexpected outcomes. CONCLUSIONS: Students' descriptions of the surgical patient's experience are disturbingly graphic. They expose suffering ranging from generalized discomfort to anguish and excruciating pain. These data suggest that surgical patients have substantial unmet needs with respect to symptom management and emotional support that, if better addressed, could improve the patient experience.

Third-Year Medical Students' Reactions to Surgical Patients in Pain: Doubt, Distress, and Depersonalization.

CONTEXT: Medical students have limited instruction about how to manage the interpersonal relationships required to care for patients in pain. OBJECTIVES: The objective of this study was to characterize the experiences of medical students as they encounter pain, suffering, and the emotional experiences of doctoring. METHODS: We used qualitative analysis to explore the content of 341 essays written by third-year medical students who described their experiences with surgical patients in pain. We used an inductive process to develop a coding taxonomy and then characterized the content of these essays related to empathy, patient-clinician interaction, and descriptions of clinical norms. RESULTS: Students found it difficult to reconcile patient suffering with the therapeutic objective of treatment. They feared an empathic response to pain might compromise the fortitude and efficiency required to be a doctor and they pursued strategies to distance themselves from these feelings. Students described tension around prescription of pain medications and worried about the side effects of medications used to treat pain. Students felt disillusioned when operations caused suffering without therapeutic benefit or were associated with unexpected complications. Although patients had expressed a desire for intervention, students worried that the burdens of treatment and long-term consequences were beyond patient imagination. CONCLUSION: These observations about patient-doctor relationships suggest that there is a larger problem among clinicians relating to patient distress and personal processing of the emotional nature of patient care. Efforts to address this problem will require explicit instruction in skills to develop a personal strategy for managing the emotionally challenging aspects of clinical work.

Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.

Lung cancer is the leading cause of cancer deaths worldwide, with the majority of mortality resulting from metastatic spread. However, the molecular mechanism by which cancer cells acquire the ability to disseminate from primary tumors, seed distant organs, and grow into tissue-destructive metastases remains incompletely understood. We combined tumor barcoding in a mouse model of human lung adenocarcinoma with unbiased genomic approaches to identify a transcriptional program that confers metastatic ability and predicts patient survival. Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis. In summary, by coupling the systematic genomic analysis of purified cancer cells in distinct malignant states from mouse models with extensive human validation, we uncovered several key regulators of metastatic ability, including an actionable pro-metastatic CD109-Jak-Stat3 axis.

Neuroendocrine tumors of the pancreas: Degree of cystic component predicts prognosis.

BACKGROUND: Although most pancreatic neuroendocrine tumors are solid, approximately 10% are cystic. Some studies have suggested that cystic pancreatic neuroendocrine tumors are associated with a more favorable prognosis. METHODS: A retrospective review of all patients with pancreatic neuroendocrine tumors who underwent operative resection between 1999 and 2014 at a single academic medical center was performed. Based on cross-sectional imaging performed before operation, pancreatic neuroendocrine tumors were classified according to the size of the cystic component relative to the total tumor size: purely cystic (100%), mostly cystic (≥50%), mostly solid (<50%), and purely solid (0%). Clinicopathologic characteristics and recurrence-free survival were assessed between groups. RESULTS: In the study, 214 patients met inclusion criteria: 8 with purely cystic tumors, 7 with mostly cystic tumors, 15 with mostly solid tumors, and 184 with purely solid tumors. The groups differed in terms of tumor size (1.5 ± 0.5, 3.0 ± 1.7, 3.7 ± 2.6, and 4.0 ± 3.5 cm), lymph node positivity (0%, 0%, 26.7%, and 34.2%), intermediate or high grade (0%, 16.7%, 20.0%, and 31.0%), synchronous liver metastases (0%, 14.3%, 20.0%, and 26.6%) and need for pancreaticoduodenectomy (0%, 0%, 6.7%, and 25.0%), respectively. No cases of purely cystic pancreatic neuroendocrine tumors were associated with synchronous liver or lymph node metastasis, intermediate/high grade, recurrence, or death due to disease. Among patients presenting without metastatic disease, 10-year recurrence-free survival was 100% in patients with purely and mostly cystic tumors versus 53.0% in patients with purely and mostly solid tumors; however, this difference did not reach statistical significance. CONCLUSION: Pancreatic neuroendocrine tumors demonstrate a spectrum of biologic behavior with an increasing cystic component being associated with more favorable clinicopathologic features and prognosis. Purely cystic pancreatic neuroendocrine tumors may represent 1 subset that can be safely observed without immediate resection.

Supporting Medical Students' Pursuit of Longitudinal Patient Experiences: Piloting an Innovative Visit Notification Tool at the Massachusetts General Hospital.

PROBLEM: Both medical educators and students have an increasing interest in longitudinal patient experiences (LPE) that allow students to work with patients at multiple points in time, often across multiple clinical settings. Despite this interest in LPE, following patients over time and across health systems remains a challenge. APPROACH: In August 2012-May 2013, with faculty support, two third-year medical students implemented a pilot program at the Massachusetts General Hospital (MGH) in the third-year block clerkship curriculum. One of the authors modified an existing novel, electronic visit notification tool (VNT) that integrates with the electronic medical record (EMR) to help students follow patients longitudinally. Students added patients to their cohort after obtaining the patient's verbal consent. Each week, the VNT sent students e-mails notifying them of all scheduled appointments for their cohort patients at all Partners HealthCare-affiliated sites. OUTCOMES: Each pilot student added approximately 20 patients to her cohort and followed 3-5 patients consistently. The pilot students felt the VNT made it significantly easier to follow patients over time, their appreciation of chronic illness care developed, and they gained a greater understanding of the integrated nature of patient care. NEXT STEPS: On the basis of student interest, the tool was made available to all MGH third-year students in March-May 2013 and offered to all MGH third-year students at the beginning of the next clinical year. Notification tools such as the VNT may enhance a hospital's existing EMR and facilitate longitudinal educational goals across all clinical clerkship models.

The needs of hospitalized patients with autism spectrum disorders: a parent survey.

OBJECTIVE: This survey assessed the in-hospital needs of patients diagnosed with autism spectrum disorders (ASDs). METHODS: Parents were recruited to complete a 21-item survey about the needs of their child with an ASD while in the hospital. ASD diagnosis was reported by parents at the time of the survey. The results of the survey were analyzed and evaluated in 3 distinct categories of need. RESULTS: We documented a range of responses associated with ASD-specific needs during hospitalization. Common concerns included child safety and the importance of acknowledging individual communication methods. CONCLUSIONS: In a population of children with ASDs, parents report a diverse range of needs while in the hospital. These data support the concept that a pragmatic assessment of individual communication and sensory differences is likely to be essential in the development of an appropriate inpatient care plan.