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1.
Appl Opt ; 57(4): 632-638, 2018 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-29400733

RESUMEN

We study the efficiency of coherent anti-Stokes Raman scattering (CARS) under frequency comb excitation. We calculate the power density of the anti-Stokes signal for two major cases: (1) molecular excitation by frequency comb and cw probe and, (2) both excitation and probing by frequency combs. In the first case, average CARS power varies as an inverse third degree of frequency combs free spectral range (FSR-3); in the second case, it varies as FSR-5. These results were applied to the CARS on blood glucose under frequency comb excitation. It was found that the resulting glucose CARS signal could approach nanowatt (nW) level at FSR=10 GHz.

2.
Opt Express ; 23(25): 32215-21, 2015 Dec 14.
Artículo en Inglés | MEDLINE | ID: mdl-26699011

RESUMEN

Through-focus scanning optical microscopy (TSOM) method based on use of a library, which is composed of simulated defocused images of nanosized silicon lines on the top of a monocrystalline silicon substrate, is demonstrated. The images are simulated using Finite-Differences in Time-Domain (FDTD) method taking into account optical aberrations of the experimental setup, which are measured experimentally. Consideration of the optical aberrations allows us to reduce the discrepancy between experimental and simulated defocused images of the samples under study to the value of ≈2%in contrast to ≈10% when the aberrations are not taken into account. It results in ≈5% recognition accuracy for critical dimension (CD) values in the range 40-150 nm.

3.
Opt Express ; 22(12): 14958-63, 2014 Jun 16.
Artículo en Inglés | MEDLINE | ID: mdl-24977589

RESUMEN

We present a novel all optical method for nanoscale pattern inspection. This method uses the chromatic aberration in an imaging optical system and a tunable light source. Such an approach allows stable and precise inspection of nanoscale objects based on an analysis of their defocused diffraction patterns without any external mechanical influence on the sample or optical system. We demonstrate the efficiency of a low cost light source tunable in the range of a light emitting diode bandwidth of ~30 nm (FWHM) for providing the required defocusing. The proposed method is tested using calibrated lines (height 50 nm, length 100 µm, critical dimension (СD) value range 40-150 nm with 10 nm steps) on a monocrystalline silicon substrate with demonstrated measurement accuracy better than 10 nm. A comparison of this all optical method with a mechanical scanning inspection system is discussed.

4.
Radiat Res ; 168(3): 382-7, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17705629

RESUMEN

A large-scale, double-stream gas puff target has been illuminated by sub-kJ, near-infrared (NIR) focused laser pulses at the PALS facility (Prague Asterix Laser System) to produce high-energy pulses of soft X rays from hot, dense plasma. The double-puff arrangement ensures high gas density and conversion efficiency from NIR to X rays approaching that typical for solid targets. In addition, its major advantage over solid targets is that it is free of debris and has substantially suppressed charged-particle emission. The X-ray emission characteristics of the source were determined for a range of gases that included krypton, xenon, N(2), CO and N(2)-CO. A demonstrated application of the xenon-based source is a single-shot damage induction to plasmid DNA. The yields of single-strand breaks (SSBs) and double-strand breaks (DSBs) were determined as a function of energy fluence adjusted by varying distance of sample from the source and thickness of aluminum filters.


Asunto(s)
Daño del ADN/efectos de la radiación , Rayos Láser , Plásmidos/química , Radiobiología/instrumentación , Investigación/instrumentación , Manejo de Especímenes/instrumentación , Rayos X , Diseño de Equipo , Análisis de Falla de Equipo , Nanotecnología/instrumentación , Nanotecnología/métodos , Plásmidos/efectos de la radiación , Dosis de Radiación , Radiobiología/métodos , Proyectos de Investigación , Manejo de Especímenes/métodos
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