[Changes in the type and amount of bone collagens in chronic suppurative otitis media]. / Izmenenie tipovogo i kolichestvennogo sootnosheniya kollagenov kostnoi tkani pri khronicheskom gnoinom srednem otite.

OBJECTIVE: Comparative assessment of the collagen-tissue interaction in the bone tissue of the middle ear structures in patients with chronic suppurative otitis media (CSOM). MATERIAL AND METHODS: A prospective study of 42 patients aged 16-60 years with CSOM admitted for reconstructive sanitizing surgery was performed. To study the collagen-tissue interaction, intraoperative samples of the bone tissue of the middle ear were used. A software calculation of vascular-stromal areas and ratios of various types of bone tissue collagen was carried out during histomorphological examination. RESULTS AND DISCUSSION: The quantitative and qualitative parameters of bone tissue collagen obtained intraoperatively in patients with CSOM were studied. The cavities of the middle ear are in the phase of a chronic purulent process, when the bone structures are morphologically disorganized according to the pathological type, and sclerosis with overgrowth of the cellular structure of the mastoid process is considered a favorable outcome for delimiting the focus of inflammation in the pyramid of the temporal bone. CONCLUSIONS: Changes in the processes of collagen remodeling of bone structures contribute to the maintenance of inflammation of the middle ear in all clinical forms of CSOM. Pathological osteogenesis can serve as an indicator of the progressive course of a purulent-destructive process in the cavities of the middle ear, which makes it possible to reliably determine the rate of bone tissue transformation to predict relapse after reconstructive and sanitizing surgery.

[Clinical case of angiosarcoma of ethmoidal labyrinth and frontal sinus, issues of morphological verification of diagnosis]. / Klinicheskii sluchai angiosarkomy reshetchatogo labirinta i lobnoi pazukhi, voprosy morfologicheskoi verifikatsii diagnoza.

A clinical case of incorrect verification of the angiosarcoma of the ethmoidal labyrinth and frontal sinus in a 36-year-old man is presented. A feature of this case is the disregard of additional research methods without taking into account the unilateralism of the pathological process, which led to the wrong tactics of surgical treatment and the development of a relapse of the disease complicated by nasal liquorrhea. A thorough examination of the patient and an analysis of a series of computer tomograms of the paranasal sinuses suggested a diagnosis of malignancy. The patient underwent neoplasm removal with fistula plastic, and histological confirmation of the presumptive diagnosis was performed.

[To the 75th anniversary of the Department of Otorhinolaryngology of South Ural Medical University]. / K 75-letiyu kafedry otorinolaringologii Yuzhno-Ural'skogo gosudarstvennogo meditsinskogo universiteta.

The 75-year history of the creation and organization of the Department of Otorhinolaryngology in the Chelyabinsk Medical Institute (now the South Ural State Medical University) is described in the article. The fascinating path of the formation of the department is setted out consistently from the first days of its creation. The achievements of the department staff are represented at all stages of its organization.

[Variants of bone tissue modification in chronic otitis media according to light and electron microscopy]. / Varianty modifikatsii kostnoi tkani pri khronicheskom srednem otite po dannym svetovoi i élektronnoi mikroskopii.

PURPOSE: Analysis of the results of surgical treatment of patients with chronic hepatitis C, depending on the characteristics of structural changes in the bone tissue of the middle ear. PATIENTS AND METHODS: Bone tissue of the retrotympanal cavities was obtained when performing various types of reconstructive sanitizing interventions: 123 samples for light microscopy and 35 samples in parallel for electron microscopy. RESULTS: The article presents the results of a retrospective analysis of the clinical features and surgical treatment of 177 patients with chronic suppurative otitis media. For histomorphological assessment, pathological processes of structural changes in the bone tissue of the middle ear were studied using acid-free microwave decalcification. CONCLUSION: The obtained data allowed to establish options for ultrastructural changes in the bone tissue of varying severity in chronic inflammation depending on the types of structure of the mastoid during the duration of the disease for more than 10 years.

[Evaluation of structural changes of bone in chronic purulent otitis media]. / Klassifikatsiia strukturnykh izmenenii kostnoi tkani pri khronicheskom gnoinom srednem otite.

Fragments of bone tissue of the temporal bone, obtained during reconstructive-sanitizing operations in patients with chronic purulent otitis media, were studied by light and electron microscopy. An analysis was made of the degree of structural changes in bone tissue in chronic inflammation at the cellular and tissue levels after a histomorphological study in microwave decalcification. The method of diagnosis reliably allowed to differentiate the diseases characterized by the rarefaction of bone tissue, due to chronic inflammation, and also to determine the processes of transformation of bone tissue. The method of diagnosis reliably allows to differentiate diseases characterized by the rarefaction of bone tissue due to chronic inflammation, as well as to determine the processes of bone tissue transformation, however, the study is time-consuming, long-lasting and expensive.