RESUMEN
We analyzed cytokine profile in blood serum of patients with uterine myoma and revealed significantly reduced level of IFNγ and a tendency towards a decrease in the levels of IL-1ß and TNFα; the levels of IL-6, IL-8, and IL-12p70 did not differ from those in healthy women. The drop in the concentrations of factors responsible for inflammation and angiogenesis in tissues are unfavorable for proliferation and differentiation of the uterine tissues.
Asunto(s)
Interferón gamma/sangre , Interleucina-1beta/sangre , Leiomioma/sangre , Factor de Necrosis Tumoral alfa/sangre , Neoplasias Uterinas/sangre , Útero/metabolismo , Adulto , Femenino , Expresión Génica , Humanos , Inflamación , Interferón gamma/genética , Interferón gamma/inmunología , Interleucina-12/sangre , Interleucina-12/genética , Interleucina-12/inmunología , Interleucina-1beta/genética , Interleucina-1beta/inmunología , Interleucina-6/sangre , Interleucina-6/genética , Interleucina-6/inmunología , Interleucina-8/sangre , Interleucina-8/genética , Interleucina-8/inmunología , Leiomioma/inmunología , Leiomioma/patología , Leiomioma/cirugía , Persona de Mediana Edad , Factor de Necrosis Tumoral alfa/genética , Factor de Necrosis Tumoral alfa/inmunología , Miomectomía Uterina , Neoplasias Uterinas/inmunología , Neoplasias Uterinas/patología , Neoplasias Uterinas/cirugía , Útero/inmunología , Útero/patología , Útero/cirugíaRESUMEN
The study examined the effect of bone marrow multipotent mesenchymal stromal cells and their products secreted into the conditioned medium on uterine microcirculatory bed in Wistar rats during chronic inflammation. The parameters of blood and lymphatic microcirculation in the uterus changed in various directions in relation to the administration routes of biomedical cell product, which is important when the cell therapy is employed in the treatment of inflammatory-degenerative alterations in the lesser pelvis organs.
Asunto(s)
Medios de Cultivo Condicionados/farmacología , Endometritis/patología , Vasos Linfáticos , Células Madre Mesenquimatosas/fisiología , Microcirculación , Útero , Animales , Células de la Médula Ósea/fisiología , Células Cultivadas , Enfermedad Crónica , Medios de Cultivo Condicionados/metabolismo , Modelos Animales de Enfermedad , Endometritis/terapia , Femenino , Vasos Linfáticos/efectos de los fármacos , Vasos Linfáticos/fisiología , Trasplante de Células Madre Mesenquimatosas , Células Madre Mesenquimatosas/metabolismo , Microcirculación/efectos de los fármacos , Ratas , Ratas Wistar , Útero/irrigación sanguínea , Útero/efectos de los fármacos , Útero/patologíaRESUMEN
We studied interferon status in children during acute respiratory infections and found that it depends on etiology, course of the disease, and individual features of the organism. The efficiency of IFN inductor anaferon (pediatric formulation) and the possibility of its application in the therapy of children with acute respiratory infections were demonstrated.