RESUMEN
AIM: To study remodeling of heart and its influence on intracellular metabolism of neutrophils in obese men. MATERIALS AND METHODS: 85 men aged 30-63 years free from coronary heart disease underwent ECG examination with the evaluation of diastolic properties and diagnostics of left ventricle remodeling with special reference to oxygen-dependent metabolism and antioxidant protection of neutrophils. RESULTS AND DISCUSSION: Increased degree of obesity in men leads to enhanced frequency of diastolic dysfunction and left ventricular myocardium remodeling accompanied by a rise in myeloperoxidase activity in neutrophils. The latter was especially high in patients with concentric hypertrophy of left ventricular myocardium. CONCLUSION: Increased degree of heart remodeling with enhanced severity of obesity in men is accompanied by activation of oxygen-dependent metabolism in neutrophils.
Asunto(s)
Neutrófilos/metabolismo , Obesidad , Disfunción Ventricular Izquierda , Remodelación Ventricular , Adulto , Insuficiencia Cardíaca Diastólica/etiología , Insuficiencia Cardíaca Diastólica/metabolismo , Insuficiencia Cardíaca Diastólica/fisiopatología , Humanos , Hipertrofia Ventricular Izquierda/etiología , Hipertrofia Ventricular Izquierda/metabolismo , Hipertrofia Ventricular Izquierda/fisiopatología , Masculino , Persona de Mediana Edad , Obesidad/complicaciones , Obesidad/metabolismo , Obesidad/fisiopatología , Estrés Oxidativo , Índice de Severidad de la Enfermedad , Estadística como Asunto , Disfunción Ventricular Izquierda/etiología , Disfunción Ventricular Izquierda/metabolismo , Disfunción Ventricular Izquierda/fisiopatologíaRESUMEN
Treatment of rat hepatocyte plasma membranes with five novel synthetic heteroprostanoids of A- and E-types significantly decreased basal activity of adenylyl cyclase. Inhibition of forskolin-stimulated activity of the enzyme was seen as well. The maximal effective concentration for all substances tested was found at approximately 5x10(-6)-1x10(-5) M. The values of half maximal concentration (IC50) for all prostanoids were at the region of 0.7-1.1 microM. Prostanoids belonging to cyclopentenone group A (U-39, U-26) were less active than analogs of 11-deoxy-PGE1 (TA-227, TA-280, and TA-239). The strongest inhibitory effect of adenylyl cyclase activity (more than 3 times) was determined in the presence of prostanoid TA-227 possessing hydrophobic 15-phenyl ring and isoxazol group in omega-chain. The investigation of AC activity in the presence of different concentrations of prostanoids and varying concentrations of Mg x ATP has demonstrated that a non-comprehensive mechanism with particular effect takes place in case of AC inhibition by the heteroprostanoids.
Asunto(s)
Inhibidores de Adenilato Ciclasa , Inhibidores Enzimáticos/farmacología , Hepatocitos/enzimología , Prostaglandinas/química , Adenilil Ciclasas/metabolismo , Alprostadil/análogos & derivados , Alprostadil/metabolismo , Animales , Membrana Celular/metabolismo , Colforsina/metabolismo , AMP Cíclico/metabolismo , Relación Dosis-Respuesta a Droga , Hepatocitos/efectos de los fármacos , Hepatocitos/metabolismo , Concentración 50 Inhibidora , Masculino , Modelos Químicos , Prostaglandinas/metabolismo , Ratas , Ratas WistarRESUMEN
Discusses the methodological problems of forensic psychiatric evaluations of mental disorders in the structure of the most incident endogenous psychosis, schizophrenia, under conditions of expert evaluation in a civil process. Presents criteria permitting the differentiation between pathological states.
Asunto(s)
Competencia Mental/legislación & jurisprudencia , Psicología del Esquizofrénico , Derechos Civiles/legislación & jurisprudencia , Psiquiatría Forense/legislación & jurisprudencia , Humanos , Competencia Mental/psicología , Psicopatología , Federación de RusiaAsunto(s)
Alcoholismo/diagnóstico , Crimen , Alcoholismo/etiología , Alcoholismo/psicología , Femenino , Humanos , Psicopatología , Psicología del Esquizofrénico , Trastorno de la Personalidad Esquizotípica/complicaciones , Trastorno de la Personalidad Esquizotípica/diagnóstico , Trastorno de la Personalidad Esquizotípica/psicología , U.R.S.S.Asunto(s)
Párpados/cirugía , Accidentes de Tránsito , Adolescente , Adulto , Párpados/lesiones , Femenino , Humanos , Masculino , Métodos , Persona de Mediana Edad , Trasplante de Piel , Colgajos Quirúrgicos , Trasplante AutólogoAsunto(s)
Quemaduras/cirugía , Párpados/cirugía , Trasplante de Piel , Párpados/lesiones , Humanos , Trasplante AutólogoAsunto(s)
Neoplasias de los Párpados/complicaciones , Párpados/cirugía , Radioterapia/efectos adversos , Adulto , Neoplasias de los Párpados/cirugía , Humanos , Masculino , Métodos , Recurrencia Local de Neoplasia/cirugía , Complicaciones Posoperatorias/cirugía , Trasplante Autólogo , Trasplante HomólogoRESUMEN
Described and figured are deutonymphs of 18 species of the genus Hirstionyssus Fonseca, 1948, parasites of small mammals (H. carnifex (L. C. Koch) Oudemans, 1913; H. blanchardi (Trouessart, 1904); H. ellobii Bregetova, 1956; H. myospalacis Zemskaja et Piontkovskaja, 1957; H. transiliensis Bregetova, 1956; H. georgicus Bregetova, 1956; H. sciurinus (Hirst, 1921); H. confucianus (Hirst, 1921); H. bregetovae Razumova, 1953; H. macedonicus (Hirst, 1921); H. pauli Willmann, 1952; H. criceti (Sulzer, 1774); H. latiscutatus (Meillon et Lavoipierre, 1944); H. apodemi Zuevsky, 1970; H. pavlovskii Zemskaja, 1959; H. soricis (Turk, 1945); H. meridianus Zemskaja, 1955; H. isabellinus Oudemans, 1913); Keys to deutonymphs of the genus Hirstionyssus are given for the first time.
