[ASSOCIATION OF CYCLIC CITRULLINATED PEPTIDE ANTIBODIES LEVEL WITH RHEUMATOID ARTHRITIS ACTIVITY BASED ON GLUCOCORTICOID RECEPTOR GENE BBL1 POLYMORPHISM].

The ambiguity of facts on connection between glucocorticoid receptor gene (GR) Bcl1 polymorphism in rheumatoid arthritis (RA) and its activity as well as lack of facts on its association with serological variants of the desease, makes ir reasonable to investigate its connections between cyclic citrullinated peptide antibodiss (ACCP) concentration and clinico-laboratorial parameters of RA (DAS 28 desease activity score, C-reactive protein concentration (CRP) and erythrocyte sedimentation rate (ESR) level based on GR gene Bcl1 polymorphism. Study involved 161 RA patients aged over 40 as well as 96 healthy individuals. Routine examination of RA diagnostics, anthropometric and molecular genetic methods were used in the research. Statistical analysis of the results was performed using SPSS-17 program. It has been proved that there is no significant difference in GR gene Bcl1 polymorphism distribution based on DAS 28 RA desease activity score, ACCP concentration and ESR level. However, we have found out that G/G genotype bearers have positive correlation relationship between ACCP titre and RA activity by laboratorial parameters (CRP, ESR),DAS 28 score and rheumatoid factor (RF) which has not been found in C/C and C/G genotype bearing patients. The above indicates the association of G/G genotype by GR gene Bcl1 polymorphism with clinico-laboratorial parameters of RA inflammatory activity. In course of the study we have identified the existance of correlation relationship between ACCP concentration and DAS 28 score of RA activity, CRP concentration and ESR level in individuals bearing G/G gene by GR gene Bcl11 polymorphism gene. The association between GR gene Bcl1 polymorphism and clinico-laboratorial parameters of RA inflammatory activity has not been found.

[Effect of non-steroid anti-inflammatory and glucocorticoid agents on development of gastrointestinal lesions in patients with rheumatic diseases]. / Vliianie nesteroidnykh protivovospalitel'nykh i gliukokortikoidnykh preparatov na razvitie porazhenii pishchevaritel'nogo kanala u bol'nykh s revmatologicheskimi zabolevaniiami.

A comparative evaluation was done of frequency and severity of upper gastrointestinal mucosal lesions in patients taking nonsteroid antiinflammatory drugs (NSAID) and glucocorticosteroids (GCS). A total of 65 rheumatic patients examined endoscopically entered the study. The patients were divided into three groups. Group I comprised 12 patients placed on GCS only, group II was 35 patients on NSAID, group III was 18 patients who received NSAID plus GCS. Gastropathies were diagnosed in 25%, 45.7%, 44.4% of patients in groups I, II, and III respectively. Group II patients had a higher incidence of serious afflictions. As far as the gastrointestinal mucosa is concerned, GCS have been shown to be superior to NSAID. A combined use of NSAID + GCS, unlike NSAID alone, has not been found to increase the risk of development of gastropathy.

[Biological age, adrenoreception and lipid peroxidation in patients with ischemic heart disease]. / Biologicheskii vozrast, adrenoretseptsiia i perekisnoe okislenie lipidov u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The article deals with electro-kinetic potential of cellular nucleus considered as an indicator of unspecific reactivity and presents some data on molecular and cellular mechanisms of adreno- and muscarino-receptive interactions, such as adrenalin, noradrenaline and DOPA blood levels, lipid peroxidation, erythrocyte resistance to peroxidation. The attempt is made to comprehend directions and trends of aforementioned processes in patients with stable and unstable stenocardia as well as in myocardial infarction with regard to sex and influence of central M-cholinoblockader amizyl. The drug provides adaptive effect, corrects affected adreno-reception, protects biomembranes from lesion, promotes their "fluidity" and reduces rigidity.