MiniCog: a method for administering psychological tests and experiments on a handheld personal digital assistant.

Because of their minimal cost, size, and weight, handheld personal digital assistants (PDAs) are appealing as a means for administering response time tasks "in the field" or to participants in longitudinal studies who need repeated access to the testing equipment. We have developed a software package that allows investigators to author simple scripts on their desktop computers and administer the compiled tasks on PDAs. MiniCog presents instructions, practice trials with auditory feedback, and visual stimuli in random or fixed sequential orders with fixed or variable durations and intertrial intervals and records single-button responses and response times. Data from each trial are stored with a user ID, user-entered demographics and notes, and a time-and-date stamp, for later upload to a desktop computer. MiniCog performs automatic calculations of mean response time and error rate, available to users with a password and stored with the other data for upload.

Neural correlates of different types of deception: an fMRI investigation.

Deception is a complex cognitive activity, and different types of lies could arise from different neural systems. We investigated this possibility by first classifying lies according to two dimensions, whether they fit into a coherent story and whether they were previously memorized. fMRI revealed that well-rehearsed lies that fit into a coherent story elicit more activation in right anterior frontal cortices than spontaneous lies that do not fit into a story, whereas the opposite pattern occurs in the anterior cingulate and in posterior visual cortex. Furthermore, both types of lies elicited more activation than telling the truth in anterior prefrontal cortices (bilaterally), the parahippocampal gyrus (bilaterally), the right precuneus, and the left cerebellum. At least in part, distinct neural networks support different types of deception.

Impact of fMRI acoustic noise on the functional anatomy of visual mental imagery.

One drawback of functional magnetic resonance imaging (fMRI) is that the subject must endure intense noise during testing. We examined the possible role of such noise on the activation of early visual cortex during visual mental imagery. We postulated that noise may require subjects to work harder to pay attention to the task, which in turn could alter the activation pattern found in a silent environment. To test this hypothesis, we used positron emission tomography (PET) to monitor regional Cerebral Blood Flow (rCBF) of six subjects while they performed an imagery task either in a silent environment or in an "fMRI-like" noisy environment. Both noisy and silent imagery conditions, as compared to their respective baselines, resulted in activation of a bilateral fronto-parietal network (related to spatial processing), a bilateral inferior temporal area (related to shape processing), and deactivation of anterior calcarine cortex. Among the visual areas, rCBF increased in the most posterior part of the calcarine cortex, but at level just below the statistical threshold. However, blood flow values in the calcarine cortex during the silent imagery condition (but not the noisy imagery condition) were strongly negatively correlated with accuracy; the more challenging subjects found the task, the more strongly the calcarine cortex was activated. The subjects made more errors in the noisy condition than in the silent condition, and a direct comparison of the two conditions revealed that noise resulted in an increase in rCBF in the anterior cingulate cortex (involved in performance monitoring) and in the Wernicke's area (required to encode the verbal cues used in the task). These results thus demonstrate a nonadditive effect of fMRI gradient noise, resulting in a slight but significant effect on both performance and the neural activation pattern.

Mental imagery of visual motion modifies the perception of roll-vection stimulation.

When viewing a wide-angle visual display, which rotates in the frontoparallel plane around the line of sight, observers experience an illusory shift of the direction of gravity; this shift leads to an apparent tilt of the body and displaces allocentric space coordinates. In this study, subjects adjusted an indicator to the apparent horizontal while viewing a rotating display. To determine whether top down processes could affect the illusion, the subjects were asked to visualize a rotating configuration of dots onto a blank central portion of the moving visual field. Visualizing dots and actually viewing the dots deflected the spatial judgment in very similar ways. These results demonstrate that top down processing can affect allocentric space coordinates.

Imagining rotation by endogenous versus exogenous forces: distinct neural mechanisms.

Previous neuroimaging studies of mental image transformations have sometimes implicated motor processes and sometimes not. In this study, prior to neuroimaging the subjects either viewed an electric motor rotating an angular object, or they rotated the object manually. Following this, they performed the identical mental rotation task in which they compared members of pairs of such figures, but were asked to imagine the figures rotating as they had just seen the model rotate. When results from the two rotation conditions were directly compared, motor cortex (including area M1) was found to be activated only when subjects imagined the rotations as a consequence of manual activity. Thus, there are at least two, qualitatively distinct, ways to imagine objects rotating in images, and these different strategies can be adopted voluntarily.

Mental imagery of high- and low-resolution gratings activates area 17.

Some, but not all, previous neuroimaging studies of visual mental imagery have found that Area 17 (primary visual cortex) is activated when people visualize objects. The present study was designed to test the hypothesis that the necessary degree of resolution of the mental image is a determining factor in whether Area 17 is activated during imagery. Eight male subjects visualized and compared sets of stripes that required high or low resolution to resolve, while their brains were scanned using 15O(CO2) positron emission tomography (PET). When imagery in general (visualization of high- and low-resolution gratings stimuli combined) was compared to an auditory baseline condition where subjects did not visualize, Area 17 was activated. However, region of interest (ROI) and statistical parametric mapping (SPM) analyses revealed no difference between imagery conditions using high- and low-resolution stimuli. These results indicate that the resolution of the stimuli alone does not necessarily determine whether Area 17 will be activated during visual mental imagery.

Hemispheric differences in body image in anorexia nervosa.

OBJECTIVE: This study tested the hypothesis that women with anorexia nervosa (AN) have an inappropriately fatter body image in the left cerebral hemisphere (LH) than in the right cerebral hemisphere (RH). METHOD: Women with AN symptomatology were compared with thin controls in a divided visual field experiment. Distorted and undistorted pictures of their own and someone else's body were flashed briefly in the left and right visual fields. Participants judged the pictures as thinner than, equal to, or fatter than the actual body size. RESULTS: The AN participants judged a higher proportion of fatter distortions as equal to their own size. They responded faster when stimuli were presented initially to the LH than when they were presented initially to the RH. In contrast, fewer thinner distortions were judged as equal to their own body size, and were judged more slowly, on LH trials than on RH trials. Controls did not show hemispheric differences when judging their own body and AN participants did not show hemispheric differences when judging pictures of somebody else. Additional analyses revealed that these findings were carried entirely by a subgroup who had AN in the past, not by the subgroup who currently had AN. DISCUSSION: The brain lateralization paradigm may prove useful in understanding body image disturbance in AN patients.

Deficits in visual cognition and attention following bilateral anterior cingulotomy.

A series of eight tests of visual cognitive abilities was used to examine pre- to post-operative performance changes in a patient receiving bilateral anterior cingulotomy. Compared with a set of eight matched control participants, post-operatively, the patient exhibited deficits in (a) the ability to sequence novel cognitive operations required to generate multipart images or rotate perceptual stimuli; (b) the ability to search for, select, and compare images of objects when the instructions did not specify precisely which objects should be visualized; and, (c) the ability to select a controlled and unpracticed response over an automatic one. Other imagery and cognitive tasks were not affected. Results are consistent with the hypothesis that anterior cingulate cortex is a component of an executive control system. One of the anterior cingulate's roles may be to monitor on-line processing and signal the motivational significance of current actions or cognitions.

Hypnotic visual illusion alters color processing in the brain.

OBJECTIVE: This study was designed to determine whether hypnosis can modulate color perception. Such evidence would provide insight into the nature of hypnosis and its underlying mechanisms. METHOD: Eight highly hypnotizable subjects were asked to see a color pattern in color, a similar gray-scale pattern in color, the color pattern as gray scale, and the gray-scale pattern as gray scale during positron emission tomography scanning by means of [(15)O]CO(2). The classic color area in the fusiform or lingual region of the brain was first identified by analyzing the results when subjects were asked to perceive color as color versus when they were asked to perceive gray scale as gray scale. RESULTS: When subjects were hypnotized, color areas of the left and right hemispheres were activated when they were asked to perceive color, whether they were actually shown the color or the gray-scale stimulus. These brain regions had decreased activation when subjects were told to see gray scale, whether they were actually shown the color or gray-scale stimuli. These results were obtained only during hypnosis in the left hemisphere, whereas blood flow changes reflected instructions to perceive color versus gray scale in the right hemisphere, whether or not subjects had been hypnotized. CONCLUSIONS: Among highly hypnotizable subjects, observed changes in subjective experience achieved during hypnosis were reflected by changes in brain function similar to those that occur in perception. These findings support the claim that hypnosis is a psychological state with distinct neural correlates and is not just the result of adopting a role.

Functional anatomy of high-resolution visual mental imagery.

This study had two purposes. First, in order to address the controversy regarding activation of the primary visual area (PVA) during visual mental imagery, regional cerebral blood flow (rCBF) was recorded while subjects performed a task that required high-resolution visual mental imagery. Second, in order to discover whether verbal descriptions can engage visual mechanisms during imagery in the same way as visual stimuli, subjects memorized 3D scenes that were visually presented or were based on a verbal description. Comparison of the results from the imagery conditions to a non-imagery baseline condition revealed no activation in PVA for imagery based on a verbal description and a significant decrease of rCBF in this region for imagery based on visual learning. The pattern of activation in other regions was very similar in the two conditions, including parietal, midbrain, cerebellar, prefrontal, left insular, and right inferior, temporal regions. These results provide strong evidence that imagery based on verbal descriptions can recruit regions known to be engaged in high-order visual processing.

Transcranial magnetic stimulation of primary motor cortex affects mental rotation.

Neuroimaging studies have shown that motor structures are activated not only during overt motor behavior but also during tasks that require no overt motor behavior, such as motor imagery and mental rotation. We tested the hypothesis that activation of the primary motor cortex is needed for mental rotation by using single- pulse transcranial magnetic stimulation (TMS). Single-pulse TMS was delivered to the representation of the hand in left primary motor cortex while participants performed mental rotation of pictures of hands and feet. Relative to a peripheral magnetic stimulation control condition, response times (RTs) were slower when TMS was delivered at 650 ms but not at 400 ms after stimulus onset. The magnetic stimulation effect at 650 ms was larger for hands than for feet. These findings demonstrate that (i) activation of the left primary motor cortex has a causal role in the mental rotation of pictures of hands; (ii) this role is stimulus-specific because disruption of neural activity in the hand area slowed RTs for pictures of hands more than feet; and (iii) left primary motor cortex is involved relatively late in the mental rotation process.

Speed of information processing in children referred for learning problems: performance on a visual filtering test.

Children referred for evaluation of learning impairment (LI, N =100) and a comparison group of nonreferred (NLI, N = 243) children were evaluated on a visual filtering task. The task was designed hierarchically to provide for evaluation of component operations-serial search, parallel search, decision, and response. With each additional processing demand, response times increased disproportionately for the LI group relative to the NLI group. Overall response time reliably predicted academic skills and cognitive ability, but was more strongly related to group membership. Thus, this nonverbal visual task is sensitive to a characteristic of children with learning problems over and above discrete academic and cognitive skills. Children with problems adapting to the demands of schooling may be distinguished by a disproportionate vulnerability to processing load.

Transient activity in the human calcarine cortex during visual-mental imagery: an event-related fMRI study.

Although it is largely accepted that visual-mental imagery and perception draw on many of the same neural structures, the existence and nature of neural processing in the primary visual cortex (or area V1) during visual imagery remains controversial. We tested two general hypotheses: The first was that V1 is activated only when images with many details are formed and used, and the second was that V1 is activated whenever images are formed, even if they are not necessarily used to perform a task. We used event-related functional magnetic resonance imaging (ER-fMRI) to detect and characterize the activity in the calcarine sulcus (which contains the primary visual cortex) during single instances of mental imagery. The results revealed reproducible transient activity in this area whenever participants generated or evaluated a mental image. This transient activity was strongly enhanced when participants evaluated characteristics of objects, whether or not details actually needed to be extracted from the image to perform the task. These results show that visual imagery processing commonly involves the earliest stages of the visual system.

Perceptual and memory biases for health-related information in hypochondriacal individuals.

Problematic health concerns characteristic of hypochondriasis may be better understood with the aid of cognitive, information processing theories. We investigated whether hypochondriacal individuals show perceptual and explicit memory biases favoring health-related information. A clinical sample of hypochondriacs (n=18) and healthy controls (n=22), and a sample of hypochondriacal (n=22) and nonhypochondriacal (n=67) patients referred for Holter monitoring, completed a computerized test of perceiving difficult-to-read words and then an encoding task followed by recall of those words. Contrary to our prediction, hypochondriacal individuals in the clinical sample did not perceive more health-related words than words not related to health. Hypochondriacal individuals in the Holter-monitoring sample showed an unexpected bias against reporting health-related words. Social class may account for some of the group differences in this sample. Hypochondriacal individuals in both samples showed better memory for health-related than nonhealth words.

If neuroimaging is the answer, what is the question?

It is unclear that we will come to a better understanding of mental processes simply by observing which neural loci are activated while subjects perform a task. Rather, I suggest here that it is better to come armed with a question that directs one to design tasks in ways that take advantage of the strengths of neuroimaging techniques (particularly positron emission tomography and functional magnetic resonance imaging). Here I develop a taxonomy of types of questions that can be easily addressed by such techniques. The first class of questions focuses on how information processing is implemented in the brain; these questions can be posed at a very coarse scale, focusing on the entire system that confers a particular ability, or at increasingly more specific scales, ultimately focusing on individual structures or processes. The second class of questions focuses on specifying when particular processes and structures are invoked; these questions focus on how one can use patterns of activation to infer that specific processes and structures were invoked, and on how processing changes in different circumstances. The use of neuroimaging to address these questions is illustrated with results from experiments on visual cognition, and caveats regarding the logic of inference in each case are noted. Finally, the necessary interplay between neuroimaging and behavioural studies is stressed.

Squinting with the mind's eye: effects of stimulus resolution on imaginal and perceptual comparisons.

Subjects either viewed or visualized arrays that were divided into four quadrants, with each quadrant containing a set of stripes. In two experiments, one array contained only relatively narrow (high-resolution) stripes, and one contained only relatively thick (low-resolution) stripes. The subjects compared sets of stripes in different quadrants according to their length, spacing, orientation, or width. When the subjects visualized the arrays, they required much more time to compare high-resolution patterns than low-resolution patterns; when the subjects saw the arrays, they evaluated both types of arrays equally easily. In addition, the results from the third experiment provide strong evidence that people use imagery in this task; in one condition, the subjects evaluated oblique sets of stripes, and in another condition, they evaluated vertical and horizontal stripes. In both imagery and perception, the subjects made more errors when evaluating oblique stimuli; in imagery, they also required more time to evaluate oblique stimuli. The results suggest that additional effort is required in imagery to represent visual patterns with high resolution. This finding demonstrates that, although imagery and perception may activate common brain regions, it is more difficult to represent high-resolution information in imagery than in perception.

The role of area 17 in visual imagery: convergent evidence from PET and rTMS.

Visual imagery is used in a wide range of mental activities, ranging from memory to reasoning, and also plays a role in perception proper. The contribution of early visual cortex, specifically Area 17, to visual mental imagery was examined by the use of two convergent techniques. In one, subjects closed their eyes during positron emission tomography (PET) while they visualized and compared properties (for example, relative length) of sets of stripes. The results showed that when people perform this task, Area 17 is activated. In the other, repetitive transcranial magnetic stimulation (rTMS) was applied to medial occipital cortex before presentation of the same task. Performance was impaired after rTMS compared with a sham control condition; similar results were obtained when the subjects performed the task by actually looking at the stimuli. In sum, the PET results showed that when patterns of stripes are visualized, Area 17 is activated, and the rTMS results showed that such activation underlies information processing.