Pupillary Responses to Dot Patterns on a Human Face Background.

Dots on natural backgrounds can elicit significant pupillary constrictions within the entire image phase associated with parasympathetic activation, suggesting disgust rather than fear. Although studies have reported that dots on faces elicit stronger disgust than dots on non-face backgrounds, it remains unclear whether dots on a face elicit stronger pupil constrictions than non-face backgrounds. Pupillometry was used while viewing dots on faces and compared with luminance- and spatial frequency-controlled images (dots on phase-scrambled faces) and luminance-controlled images (face only, phase-scrambled faces). Relative pupillary constrictions were elicited when dots were placed on faces and phase-scrambled faces; however, the response to dots on faces did not differ significantly from that to the control stimuli. Approximately 3-5 s after stimulus onset, pupillary responses to dots on faces recovered to baseline faster than those to dots on phase-scrambled faces with a larger pupil size. The initial pupillary constrictions observed are consistent with those in response to dots on natural backgrounds, suggesting that regardless of the background, dots may stimulate parasympathetic activation and elicit disgust rather than fear. The faster recovery from the pupil constriction and larger pupil size in the later phase may be caused by a dynamic balance between the sympathetic and parasympathetic neuronal activities.

Robot occupations affect the categorization border between human and robot faces.

The Uncanny Valley hypothesis implies that people perceive a subjective border between human and robot faces. The robot-human border refers to the level of human-like features that distinguishes humans from robots. However, whether people's perceived anthropomorphism and robot-human borders are consistent across different robot occupations remains to be explored. This study examined the robot-human border by analyzing the human photo proportion represented by the point of subjective equality in three image classification tasks. Stimulus images were generated by morphing a robot face photo and one each of four human photos in systematically changed proportions. Participants classified these morphed images in three different robot occupational conditions to explore the effect of changing robot jobs on the robot-human border. The results indicated that robot occupation and participant age and gender influenced people's perceived anthropomorphism of robots. These can be explained by the implicit link between robot job and appearance, especially in a stereotyped context. The study suggests that giving an expected appearance to a robot may reproduce and strengthen a stereotype that associates a certain appearance with a certain job.

Analysis of Japanese consumers' attitudes toward the digital transformation of OTC medicine purchase behavior and eHealth literacy: an online survey for digital experience design.

Introduction: Since the enactment of the revised Pharmaceutical Affairs Act in Japan in 2009, self-medication practices have increased in the country. However, studies report that consumers pay little attention to the medication facts and risks indicated on the packages of over-the-counter (OTC) medicines, which could be a potential risk. Since the COVID-19 pandemic, the digital transformation of purchasing OTC medicines has progressed. As an appropriate design for the digital transformation is likely to improve consumers' literacy and them obtaining medical information, this study systematically examines Japanese consumers' attitudes toward the digital transformation of OTC medicine purchase behavior and its correlation to eHealth literacy, exploring an appropriate digital experience design in purchasing OTC medicine. Methods: Participants from the Greater Tokyo Area of Japan participated in an online survey. Consumers' current behavior and preferences in accessing OTC medicine, receiving medication guidance, and obtaining medical information were examined. eHealth literacy was assessed using the J-eHEALS. Descriptive statistics, text mining, and thematic analysis were conducted to answer research questions. Results: Over 89% of the respondents who had experience in purchasing OTC medicines preferred local pharmacies or stores rather than online purchasing, p < 0.001. Obtaining medicine guidance in pharmacies or stores was the main preference over other approaches, p < 0.001. Furthermore, most of the participants accepted selecting medicine on shelves and digital screens in-store. However, they were accustomed to using smartphones to obtain additional information at the pharmacy or drug store, p < 0.001; this behavior was positively correlated with eHealth literacy, p < 0.001. Conclusions: Japanese consumers are seeking a combination of conventional and digital behaviors for purchasing OTC medicine rather than opting for a particular method. Most consumers prefer purchasing and receiving instructions in-store while searching for additional decision-making information online. eHealth literacy is positively associated with digital behaviors of OTC medicine information acquisition but less associated with medicine purchases and selections. The hybrid digital experience design may enhance the OTC medicine purchase experience and reduce potential risks by providing appropriate information.

Japanese Consumers' Attitudes towards Obtaining and Sharing Health Information Regarding Over-the-Counter Medication: Designing an Over-the-Counter Electronic Health Record.

Designing an over-the-counter medication electronic health record (OTC-EHR) may help improve OTC usage. An online survey for the conceptual OTC-EHR design examined participant characteristics, attitudes towards obtaining user-shared OTC medication information, health-related application usage, and the inclination to share anonymized health information. Descriptive statistics, tests to assess statistical significance, and text mining were used to analyze the results. The findings revealed that Japanese consumers, particularly those with high eHealth literacy and women, possess relatively positive attitudes towards obtaining user-shared OTC medication information than those with low eHealth literacy (t (280.71) = -4.11, p < 0.001) and men (t (262.26) = -2.78, p = 0.006), respectively. Most consumers own smartphones but do not use health-related applications. A minority held positive attitudes about sharing anonymized health information. The perceived helpfulness of OTC-EHR was positively associated with the usage of health-related applications (χ2 (4) = 18.35, p = 0.001) and attitude towards sharing anonymized health information (χ2 (3) = 19.78, p < 0.001). The study findings contribute towards OTC-EHR's design to enhance consumers' self-medication and reduce risks, while the psychological barriers to sharing anonymized health information should be improved by increasing the OTC-EHR's penetration rate and engaging in appropriate information design.

Depth perception between dots and the background face reduces trypophobic discomfort.

BACKGROUND: Studies have shown that viewing a cluster of dots evokes feelings of discomfort in viewers and that the discomfort becomes especially strong when the dots are placed on background images of human skin. This phenomenon has been explained by the physical properties and spatial and semantic relationships between the dots and the background. However, it was not known whether the perceived, as well as the physical, spatial relationships contributes to the generation of discomfort. METHODS: We evoked illusory depth perception between black dots and the background face by drawing shadow-like gray dots around the black dots, while keeping the same black dots at the same positions, and examined whether illusory depth perception could increase or decrease discomfort. In each trial, participants viewed one of the following types of facial images: (a) face-only (face without dots), (b) a cluster of black dots on the face, (c) a cluster of gray dots on the face, and (d) a cluster of black dots and shadow-like gray dots on the face. After seeing each picture, they evaluated how much discomfort they felt from viewing the picture using a Likert scale and reported whether they perceived depth between the dots and the face. RESULTS: Participants felt discomfort toward all three types of faces with dots, that is, faces with black dots, gray dots, and both. However, interestingly, participants felt less discomfort when both black and gray dots were presented on the face than when only black dots were presented. The participants perceived depth between the black dots and the face in 85% of the trials with black dots and shadow-like gray dots, and there was a significant correlation between discomfort and frequency of depth perception. However, in the trials with black dots only and gray dots only, they perceived depth in only 18% and 27% of the trials, respectively, and the correlations between the frequencies of depth perception and discomfort were not significant. CONCLUSIONS: Our results suggest that the perceived spatial relationship, such as attached vs. separate, as well as the physical spatial relationship, contribute to the generation of discomfort.

A social media network analysis of trypophobia communication.

Trypophobia has attracted scientific attention in recent years. Few related studies have recruited participants using online methods, and even less is known about health communication in an environment where trypophobia was first widely discussed (i.e., the Internet). This study describes communication patterns in a Facebook group for trypophobia by detecting frequent topics, top contributors, and their discourses. We identified key commenters and performed word frequency analysis, word co-occurrence analysis, topic modeling, and content analysis. Impactful users posted and replied more often when discussing peer-reviewed science. Triggering content was actively removed by the group administrators. A wide variety of triggers not discussed in trypophobia-related literature were frequently mentioned. However, there was a lack of discussion on peer-reviewed treatments. The combination of a few expert and many supportive amateur gatekeepers willing to understand trypophobia, along with active monitoring by administrators, might contribute to in-group trust and the sharing of peer-reviewed science by top users of the trypophobia Facebook group.

Investigating the relationship between users' eye movements and perceived product attributes in design concept evaluation.

Eye movements as the indicators of human information processing have been studied in many domains. However, it is not clear how users' eye movements differ among specific product attribute, while visual impression of a product plays a crucial part in distinguishing product designs. Therefore, this paper attempts to establish guidance for exploring eye tracking applications in design concept validations through two case studies. The first case study investigated the product attributes based on the theory of cognitive-affective emotions. The second investigated the product attributes for apparent functionality and affective quality. The eye movements of 105 participants were analyzed when they evaluated the products images. The results indicated that product attributes perceived in evaluation tasks can be predicted from eye movements. Moreover, compared to the new users, experienced users had a longer mean fixation duration and tended to form their impressions of the product from multiple components.

Size resolved characteristics of urban and suburban bacterial bioaerosols in Japan as assessed by 16S rRNA amplicon sequencing.

To study the size-resolved characteristics of airborne bacterial community composition, diversity, and abundance, outdoor aerosol samples were analysed by 16S rRNA gene-targeted quantitative PCR and amplicon sequencing with Illumina MiSeq. The samples were collected using size-resolved samplers between August and October 2016, at a suburban site in Toyama City and an urban site in Yokohama City, Japan. The bacterial communities were found to be dominated by Actinobacteria, Firmicutes, and Proteobacteria. At the genus level, we found a high abundance of human skin-associated bacteria, such as Propionibacterium, Staphylococcus, and Corynebacterium, in the urban site. Whereas, a high abundance of bacteria associated with soil and plants, such as Methylobacterium and Sphingomonas, was observed in the suburban site. Furthermore, our data revealed a shift in the bacterial community structure, diversity, and abundance of total bacteria at a threshold of 1.1-µm diameter. Interestingly, we observed that Legionella spp., the causal agents of legionellosis in humans, were mainly detected in > 2.1 µm coarse particles. Our data indicate that local environmental factors including built environments could influence the outdoor airborne bacterial community at each site. These results provide a basis for understanding the size-resolved properties of bacterial community composition, diversity, and abundance in outdoor aerosol samples and their potential influence on human health.

Impaired cognitive modification for estimating time duration in Parkinson's disease.

Parkinson's disease (PD) is associated with various cognitive impairments. However, the nature of cognitive modification in patients with PD remains to be elucidated. In the present study, we examined whether patients with PD could correct and maintain subjective time duration and line length estimation. After training sessions, in which participants repeatedly memorized either a duration or a length, we compared a learning performance in 20 PD patients with 20 healthy controls. In the case of duration in the PD patients, the learned durations immediately returned to baseline of pre-training within a few minutes. However, the patients' ability to learn length estimation remained unimpaired. In contrast, healthy controls were able to retain the learned duration and length estimations. Time compression in PD's internal clock may become entrained to their altered duration estimation even after learning of accurate time duration. These deficits may be associated with disrupting cognitive modification in PD.

Face-Inversion Effect on Disgust Evoked by a Cluster of Dots.

A cluster of dots such as lotus seed pods evokes extremely strong disgust when it is placed on human and animal skins. However, few empirical studies have examined the role of the background image, such as skin, in the generation of disgust. In this study, we investigated whether the orientation of background faces influences the disgust evoked by the dot pattern. The participants were asked to evaluate disgust to an upright, inverted, or phase-scrambled face image with or without a cluster of dots on it and then complete a questionnaire measuring trypophobia proneness (Trypophobia Questionnaire). The results suggested that disgust was intensified by the background faces, especially by the upright faces. The intensification of disgust in the upright face was correlated positively with the Trypophobia Questionnaire scores. The results indicated a face-inversion effect on the disgust to the dot pattern, suggesting a significant role of the background image.

Development of the Japanese version of the Visual Discomfort Scale.

BACKGROUND: Visual stimuli, such as stripes and texts, can induce "visual discomfort" including perceptual and somatic symptoms. Individuals reporting high levels of visual discomfort might experience migraine headache and may have reduced reading efficiency due to visual perceptual difficulties. This study aimed to develop and validate the Japanese version of the Visual Discomfort Scale, which measures proneness to visual discomfort. METHODS AND RESULTS: In Survey 1, 428 adults completed the Japanese version and a questionnaire assessing migraine morbidity. Rasch analysis revealed that the Japanese version is a unidimensional scale with a high amount of unexplained variance due to random noise rather than another dimension, and has high person and item reliabilities. Participants with migraine exhibited high scores in the Japanese version, indicating the construct validity of the scale. Survey 2 with 118 adults revealed a strong test-retest correlation for the Japanese version, indicating the stability of the scale. CONCLUSION: The Japanese version of the Visual Discomfort Scale is a sufficiently reliable and valid scale for assessing visual discomfort, although its unidimensionality leaves room for further improvements.

Agency over Phantom Limb Enhanced by Short-Term Mirror Therapy.

Most amputees experience phantom limb, whereby they feel that the amputated limb is still present. In some cases, these experiences include pain that can be alleviated by "mirror therapy." Mirror therapy consists of superimposing a mirrored image of the moving intact limb onto the phantom limb. This therapy provides a closed loop between the motor command to the amputated limb and its predicted visual feedback. This loop is also involved in the sense of agency, a feeling of controlling one's own body. However, it is unclear how mirror therapy is related to the sense of agency over a phantom limb. Using mirror therapy, we investigated phantom limb pain and the senses of agency and ownership (i.e., a feeling of having one's own body) of the phantom limb. Nine upper-limb amputees, five of whom reported recent phantom limb pain, underwent a single 15-min trial of mirror therapy. Before and after the trial, the participants completed a questionnaire regarding agency, ownership, and pain related to their phantom limb. They reported that the sense of agency over the phantom limb increased following the mirror therapy trial, while the ownership slightly increased but not as much as did the agency. The reported pain did not change; that is, it was comparably mild before and after the trial. These results suggest that short-term mirror therapy can, at least transiently, selectively enhance the sense of agency over a phantom limb, but may not alleviate phantom limb pain.

Embodied prosthetic arm stabilizes body posture, while unembodied one perturbs it.

Senses of ownership (this arm belongs to me) and agency (I am controlling this arm) originate from sensorimotor system. External objects can be integrated into the sensorimotor system following long-term use, and recognized as one's own body. We examined how an (un)embodied prosthetic arm modulates whole-body control, and assessed the components of prosthetic embodiment. Nine unilateral upper-limb amputees participated. Four frequently used their prosthetic arm, while the others rarely did. Their postural sway was measured during quiet standing with or without their prosthesis. The frequent users showed greater sway when they removed the prosthesis, while the rare users showed greater sway when they fitted the prosthesis. Frequent users reported greater everyday feelings of postural stabilization by prosthesis and a larger sense of agency over the prosthesis. We suggest that a prosthetic arm maintains or perturbs postural control, depending on the prosthetic embodiment, which involves sense of agency rather than ownership.

Trypophobia is predicted by disgust sensitivity, empathic traits, and visual discomfort.

Trypophobia refers to disgust for a cluster of objects, and is considered an extension of disgust for dangerous objects. Furthermore, trypophobic images possess certain spatial properties that can induce perceptually unpleasant states (i.e., visual discomfort). We examined whether trypophobia is associated with disgust sensitivity, empathic traits, and visual discomfort. Japanese adults (n = 126) completed four scales: the Trypophobia Questionnaire, which measures trypophobia proneness; the Disgust Scale-Revised, which measures disgust sensitivity; the Interpersonal Reactivity Index, which measures empathic traits; and the Visual Discomfort Scale, which measures proneness to visual discomfort. Trypophobia proneness was found to be predicted by Core disgust sensitivity (i.e., threat of disease), Personal Distress (i.e., the empathic trait of self-oriented emotional distress), and proneness to visual discomfort. We suggest a number of potential factors relating to individual differences in trypophobia and the possible cognitive and perceptual mechanisms underlying trypophobia.

Development of Embodied Sense of Self Scale (ESSS): Exploring Everyday Experiences Induced by Anomalous Self-Representation.

The scientific exploration of the self has progressed, with much attention focused on the Embodied Sense of Self (ESS). Empirical studies have suggested the mechanisms for self-representation. On the other hand, less attention has been paid to the subjectivity itself of the self. With reference to previous studies, the current study collected items that reflect the ESS and statistically extracted three factors for it: Ownership, Agency, and Narrative. The developed questionnaire [Embodied Sense of Self Scale (ESSS)] showed good enough validity and reliability for practical use. Furthermore, ESSS discriminated schizophrenia, a disorder of the ESS, from controls. We discuss the factorial structure of ESS and the relationship among factors on the basis of the current results.

Hesitant avoidance while walking: an error of social behavior generated by mutual interaction.

Altering physical actions when responding to changing environmental demands is important but not always effectively performed. This ineffectiveness, which is an error of social behavior generated by mutual interactions, is not well understood. This study investigated mechanisms of a hesitant behavior that occurs in people walking toward each other, causing people to move in the same direction when attempting to avoid a collision. Using a motion capture device affixed to 17 pairs, we first confirmed the hesitant behavior by a difference between the experimental task, which involved an indeterminate situation to assess the actions of another individual, and the control task, which involved a predetermined avoiding direction, in a real-time situation involving two people. We next investigated the effect of three external factors: long distance until an event, synchronized walking cycle, and different foot relations in dyads on the hesitant behavior. A dramatic increase in freezing and near-collision behavior occurred in dyads for which the avoiding direction was not predetermined. The behavior related with the combination of long distance until an event, synchronized walking cycle, and different foot relations in dyads. We found that the hesitant behavior is influenced by an interpersonal relationship under enough distance to predict other movement. The hesitant behavior has possibly emerged as an undesired by-product of joint action. These results contribute to our understanding of the mechanisms of adaptive control of perception-action coupling in mutual interaction.

Illusory visual motion stimulus elicits postural sway in migraine patients.

Although the perception of visual motion modulates postural control, it is unknown whether illusory visual motion elicits postural sway. The present study examined the effect of illusory motion on postural sway in patients with migraine, who tend to be sensitive to it. We measured postural sway for both migraine patients and controls while they viewed static visual stimuli with and without illusory motion. The participants' postural sway was measured when they closed their eyes either immediately after (Experiment 1), or 30 s after (Experiment 2), viewing the stimuli. The patients swayed more than the controls when they closed their eyes immediately after viewing the illusory motion (Experiment 1), and they swayed less than the controls when they closed their eyes 30 s after viewing it (Experiment 2). These results suggest that static visual stimuli with illusory motion can induce postural sway that may last for at least 30 s in patients with migraine.

Agency over a phantom limb and electromyographic activity on the stump depend on visuomotor synchrony: a case study.

Most patients, post-amputation, report the experience of a phantom limb. Some even sense voluntary movements when viewing a mirror image of the intact limb superimposed onto the phantom limb. While delayed visual feedback of an action is known to reduce a sense of agency, the effect of delayed visual feedback on phantom motor sensation (i.e., sense of controlling a phantom limb) has not been examined. Using a video-projection system, we examined the effect of delayed visual feedback on phantom motor sensation in an upper-limb amputee (male; left upper-limb amputation). He was instructed to view mirrored video images of his intact hand clasping and unclasping during a phantom limb movement. He then rated the intensity of the phantom motor sensation. Three types of hand movement images were presented as follows: synchronous, asynchronous with a 250-ms delay, and asynchronous with a 500-ms delay. Results showed that phantom motor sensation decreased when the image was delayed by 250 and 500 ms. However, when we instructed the patient to adjust the phase of phantom limb movement to that of the image with a 500-ms delay, phantom motor sensation increased. There was also a positive correlation between intensity of phantom motor sensation and electromyographic (EMG) activity on deltoids at the patient's stump. These results suggest that phantom motor sensation and EMG activity on the stump depend on visuomotor synchrony and top-down effects.

[Prosopagnosia and facial expression recognition].

This paper reviews clinical neuropsychological studies that have indicated that the recognition of a person's identity and the recognition of facial expressions are processed by different cortical and subcortical areas of the brain. The fusiform gyrus, especially the right fusiform gyrus, plays an important role in the recognition of identity. The superior temporal sulcus, amygdala, and medial frontal cortex play important roles in facial-expression recognition. Both facial recognition and facial-expression recognition are highly intellectual processes that involve several regions of the brain.

[Epilepsy with higher brain dysfunction].

Acquired higher brain dysfunction is for the most part due to cerebral vascular disease, but epilepsy may also be a cause. In this study with five patients, we discuss the advantages of anti-epileptic drugs (AEDs) for persistent higher brain dysfunction. The patients showed chronic amnesia or acute aphasia, with associated symptoms like personality change. All five cases affected automatism or convulsive attack, though only after the emergence of higher brain dysfunction and administration of AEDs. There were underlying diseases like cerebral arteriovenous malformation in four cases, but the other patient had none. Electroencephalogram and single photon emission computed tomography revealed one case of aphasia epilepsy with higher brain dysfunction. These results suggest the potential therapeutic efficacy of AEDs for persistent higher brain dysfunction, and we must differentiate epilepsy with higher brain dysfunction from dementia or cerebral vascular disease.