RESUMEN
Family Mediterranean fever (FMF, Periodic disease) is a hereditary autosomal recessive disease and belongs to orphan diseases. Abdominal pain syndrome in this pathology is accompanied by various complaints from the gastrointestinal tract. The aim of the study was to study the state of the gastrointestinal tract in children with FMF. We observed 66 children aged 4 to 18 years with genetically confirmed FMF. The most frequent complaints were complaints of vomiting - 33.3% of cases and liquefied stools - 24.2% and nausea - 16.7% of cases. Erosive changes in the upper gastrointestinal tract were most often observed in the esophagus (up to 15.4%) during the attack and outside it. In endoscopic examination of the colon during the attack, changes in CO were significantly more common.