[BONE METABOLISM AND BONE MINERAL DENSITY IN CHILDREN WITH RECURRENT BRONCHITIS].

The aim - to determine the bone metabolism status and bone mineral density (BMD) in children with recurrent bronchitis (RB). 120 children aged 6 to 10 years were examined. Formed 2 groups: 1st group - children with RB (n=60); 2nd group - children occasionally suffering of upper respiratory tract infections (n=60). The average age was 8 years 2 months. Among children with RB, compared with children of the 2nd group, an increase in the number of patients with an increase in alkaline phosphatase activity (by 35.0%) (p<0.05), and serum osteocalcin level (by 66.7%) (p<0.05) was revealed, collagen type 1 degradation products (by 15.0%) (p<0.05), parathyroid hormone (by 13.3%) (p<0.05), decrease of serum 25(OH)D less than 30 ng/ml (by 59.3%) (p<0.05). A DXA in children with RB showed the presence of 24 (40.0%) episodes of decreased BMD in the L1, 25 (41.7%) episodes in L2, 24 (40.0%) episodes in L3, 27 (45.0%) episodes in L4, 28 (46.7%) cases in the left femur neck, 22 (36.7%) cases in the right femur neck. In children with RB was established activation of bone resorption on background of vitamin D deficiency and BMD decrease.

[SERUM CONTENTS OF SUBSTANCE P, ENDOTHELIN-1 AND VASOACTIVE INTESTINAL PEPTIDE IN CHILDREN WITH RECURRENT BRONCHITIS AND VERTEBROBASILAR INSUFFICIENCY].

The recurrent bronchitis (RB) course is caused by the bronchi secretory-evacuation mechanisms state, which provide clearance from pathogens. This mechanism can be disrupted by vegetative reflexes and neuropeptides imbalance that develops in children with the syndrome of the vertebrobasilar arterial system (SVBAS). The objective: study of the neurogenic maintenance of the RB pathogenesis in children with SVBAS by studying the serum content of substances affecting of the bronchial mucosa secretory-evacuation function and inflammatory activity (substance P, vasoactive intestinal peptide - VIP and endothelin-1 - ET-1). 90 children aged 7 to 11 years were examined, 3 observation groups were formed: Group 1 - children with RB and SVBAS (n=30); Group 2 - children with SVBAS without RB (n=30); Group 3 - children with RB without SVBAS (n=30). In the Group 1, compared with the 2nd and 3rd, there was an increase in the children number with high serum content of substance P (by 66.7% and 50.0%, respectively, p<0.05) and ET -1 (by 23.3% and 40.0%, respectively, p<0.05), low content of VIP (by 46.7% and 23.4%, respectively, p<0.05). Children with RB and SVBAS have serum level imbalance of the pro-inflammatory substance P, ET-1 and anti-inflammatory VIP as the bronchitis severe course basis.