Opposite Orientation of Backbone Inclination in Pyranosyl-RNA and Homo-DNA Correlates with Opposite Directionality of Duplex Properties.

Backbone inclination is a parameter which can be used for the classification of the structure type of oligonucleotide duplexes. Its significance for the interpretation of the sequence dependence of duplex stability is illustrated based on examples of the p-RNA and homo-DNA series.