RESUMEN
Screening for congenital hypothyroidism was carried out by measuring thyroid stimulating hormone (TSH) on dried blood spots (mean + 2SD cut off value 12 microU/ml) by fluoroimmunoassay using DELFIA kits. A total of 20,021 infants were screened, and seven cases with congenital hypothyroidism were detected, giving an incidence of congenital hypothyroidism of 1:2860 (female:male ratio 6:1). In four of seven infants with congenital hypothyroidism (57%) the mother also had thyroid disease, supporting the importance of genetic factors as a cause of congenital hypothyroidism. Transient hyperthyrotropinaemia occurred in 654 infants (recall rate 3.3%). There was a significant association of transient hyperthyrotropinaemia only with cardiac failure at birth or caesarean section (p < 0.01). Family studies showed no predisposition to thyroid diseases associated with a transient increase of TSH.
Asunto(s)
Hipotiroidismo Congénito , Hipotiroidismo/diagnóstico , Tamizaje Neonatal , Estonia/epidemiología , Femenino , Humanos , Hipotiroidismo/epidemiología , Recién Nacido , Masculino , Hormonas Tiroideas/análisisRESUMEN
Magnesium and ionized calcium in mixed umbilical cord blood was assessed colorimetrically in 38 distressed and 21 healthy term newborn infants. Distressed infants with a severe or moderate degree of hypoxic-ischemic encephalopathy (HIE) (n = 8) had significantly lower (p < 0.001) concentrations of magnesium (0.52 +/- 0.08 mmol/L) compared to the control group (0.69 +/- 0.06 mmol/L). No differences in concentrations of ionized calcium between distressed and control infants were detected.