[The efficacy of the orthodontic treatment of pathological dental abrasion complicated by temporomandibular joint dysfunction]. / Effektivnost' ortopedicheskogo lecheniia patologicheskoi stiraemosti zubov, oslozhnennoi disfunktsiei visochno-nizhnecheliustnogo sustava.

A total of 426 patients, 215 female and 211 male ones, aged 40 to 65, were treated for abnormal abrasion of the teeth; 52 of these developed temporomandibular joint dysfunction. Orthodontic and physiotherapeutic methods were added to the complex of therapeutic measures for this patient population. Orthodontic treatment was aimed at normalization of the occlusion height (interalveolar space) and mandibular status and was carried out with a plastic cup attached to the denture for a period of up to 6 months. This was followed by rational prosthetics. Good late results were achieved in 48 patients (92.2 percent) with temporomandibular joint dysfunction. Four patients developed recurrences of such dysfunction in various periods after the treatment.

[Heterochromatin of the human Y chromosome as an example of selfish DNA]. / Geterkhromatin Y-khromosomy cheloveka kak primer égoisticheskoi DNK.

The nature of human Y-chromosome of Q-positive heterochromatic region is discussed. Both the authors data and those from literature show the existence of human population polymorphism with respect to the appearance of this region which consists of one or several bright fluorescent blocks. Their multiplication results probably from an unequal sister-strand crossing-over. Absence of these blocks has no visible phenotypic effect. Their extra multiplication affects the embryonal and possibly postnatal psychic development. It is supposed that Q-positive heterochromatin is an example of selfish DNA in the human genome.

[Spectral luminescence studies of cells stained with acrichine derivatives]. / Spektral'nye liuminestsentnye issledovaniia kletok, okrashennykh proizvodnymi akrikhina.

Excitation and fluorescence spectra are given of quinacrine derivative solutions, of buccal epithelium cell nuclei, of peripheral blood cells, and of isolated chromosomes treated with propyl-quinacrine mustard. It is confirmed that the differential cell treatment with quinacrine derivates may be observed in aqueous solutions only. Data obtained allow us to give some recommendations for employment of optimal filters and dichroic beam-splitters in the fluorescence microscopy of chromosomes treated with quinacrine derivatives.

[X-ray anatomic features of the skeleton in the 47, XYY syndrome]. / Rentgenoanatomicheskie osobennosti skeleta pri sindrome 47, XYY.

The data are represented on the examination of 11 men with 47, XYY karyotype, roengenography of some parts of their skeletals including. The result are compared with the data on investigation of 430 human males chosen from a population. This anomaly in the karyotype stipulates, in the skeletal formation, a tendency to high stature, a certain flattening in the head of the radiocarpal articulation, the kneepan and the distal contour of the femoral bone. Nearly in a half of all observations valgus deviation of the ulnar articulation was somewhat increased, in 3 cases--inhibition of some synostoses in the growth zones of the extremities was noted. A supposition is made that in males the insidence of cleft in sesamoid bones in the lower extremities is increased in the presence of the extra Y-chromosome.

[Effect of the Y chromosome on the morphology of human F-chromatin under normal and pathological conditions]. / Vliianie Y-khromosomy v norme i patologii na morfologiiu F-khromatina cheloveka.

Morphological peculiarities of brightly fluorescent chromatin (referred to as F-chromatin) in cell nuclei of buccal epithelium stained with propil-quinacrine mustard are studied in 94 healthy men and in 67 healthy women; in 4 men with 46,XYq--, I man with 46,XYq+; in 15 patients with the Kleinfelter syndrome (47,XXY) in 7 women with 46,XY and 5 males with 47,XYY. Diametre of F-chromatin bodies in buccal cells of healthy men varied within 0.9--0.2 mkm. Classification of types of interphase nuclei is proposed based on the rise, quantity and arrangement of F-chromatin bodies. The study of F-chromatin and X-chromatin showed independent behavior of these structures in cells of buccal smears obtained from 15 patients with the Kleinfelter syndrome.

[Schizophrenic and schizophrenic-like manifestations in syndrome 47, XYY]. / Shizofrenicheskie i shizofrenopodobnye proiavleniia pri sindrome 47, XYY

The authors examined 4446 patients in mental hospitals. Among these patients 15 displayed the 47 XYY syndrome and 3 with mosaicism 46 XY/47 XYY. A study of these patients showed that in 5 cases they were qualified as schizophrenic. They were study died from 2-5 years. In 4 cases the diagnosis of schizophrenia was not confirmed. In one case the authors diagnosed the disease as an atypical form of schizophrenia. The clinical traits of the disease in this case are associated with a supplementary Y somasomia.

[Identification of several chromosome aberrations in man by the fluorescent method using quinacrine yprite]. / Identifikatsiia nekotorykh khromosomnykh perestroek u cheloveka fluorestensentnym metodom s ispol'zovaniem akrikhi-iprita

The applications of the fluorescent staining of chromosomes with quinacrine mustard allowed to identify a dicentric Y-chromosome in two patients with defected external gynaetalies: a boy of 15 years old and a girl of 2 years old. Both the patients had mosaicism of sex chromosomes: 45, x/46, x dic (Y). The dicentric Y-chromosome, resembling chromosome, 16, had bright luminescence of the thelomeric regions characteristic of the normal Y-chromosome. Besides, a balanced autosomic translocation t (1, 14) (q 31, q 3) was found in the girl identified also with quinacrine mustard fluorescent staining.

[Study of Y-chromatin in the buccal epithelium of man]. / Issledovanie Y-khromatina v bukkal'nom épitelii cheloveka

Investigation was carried on by fluorescent-microscopic technique, smears of buccal epithelium being stained with acrichinium-mustard gas. The extent, form, location in a nucleus and the frequency of Y-chromatin in human buccal smears were studied. In medico-genetic practice this method is employed for initial determination of chromosome sex in disease associated with anomalies of sex chromosomes.