[Evaluation of the effectiveness of drug therapy of autonomic paroxysms in relation to the variability of cardiac rhythm]. / Otsenka éffektivnosti lekarstvennoi terapii vegetativnykh paroksizmov po spektru variativnosti ritma serdtsa.

A study was made of changes in the amplitude and percentile contribution of respiratory waves and slow waves of heart rhythm (SW1 with a period of 8-14 s and SW2 with a period of 14-60 s) in 13 patients with panic attacks (PA) in the lying position after the 3-day monotherapy with the beta-blocker propranolol, alpha-blocker phentolamine and diazepam. Propranolol normalized baroreflex regulation of arterial pressure and raised SW1. Phentolamine, producing an analogous effect, enhanced sympathoadrenal activation and the rate of PA, reducing RW. The amplitude of SW2 that correlated with emotional tension and anxiety fell only as a result of the administration of diazepam. The latter drug did not influence the baroreflex (via SW1) and vagal (via RW) mechanisms of regulation.

[The role of local cerebral mechanisms in the pathology of autonomic functions]. / Rol' lokal'nykh tserebral'nykh mekhanizmov v patologii vegetativnykh funktsii.

Heart rhythm was subjected to mathematical analysis in patients of neurosurgical department. The data allowed to make conclusions on the role of the level and lateralization of lesions in autonomic pathology. Right hemisphere and brainstem were shown to have a major impact on the baseline autonomic tone and its regulation. Autonomic supply to actions is ensured by rhinencephalic structures of both left and right hemispheres. The data are valuable for neurology as criteria of topic diagnosis when lateralization of lesions should be clarified.

[Heart rhythm in cardiovascular disorders of neurotic origin]. / Ritm serdtsa pri kardiovaskuliarnykh narusheniiakh nevroticheskogo geneza.

Cardiac rhythm (CR) and vegetative parameters at rest and after a series of short-term loads were compared in normal subjects and neurotic patients with the cardiologic syndrome (group 1) and those with vegetovascular crisis (Group 2). At rest, second-group patients demonstrated the best CR stabilization (by sigma R-R), with the CR oscillation pattern respiratory constituent (RC) diminished and its slow-wave (SW2) constituent prevailing as well as the highest arterial BP and intrasystemic dissociations (the Kërdo index). First-group patients showed the greatest sigma R-R, with the SW2 prevailing in the presence of a greater RC contribution, as compared to group 2 patients. Different patterns of post-exercise change were demonstrated: normal subjects showed increased heart rate, BP and sigma R-R, with doubled SW1 contribution, reduced SW2 and unchanged RC, an evidence of sympathetic mobilization in the presence of vagal pacemaker effects. In second-group patients, heart rate and BP were reduced, the contribution of SW2 increased, and that of SW1 and RC diminished, while the initial CR stabilization by the sigma R-R remained unchanged. Inter-systemic dissociations were demonstrated, using the Hildebrandt index; this combination signals overstrain of the controlling mechanisms, growing centralization of CR control and disadaptation. In first-group patients, BP rose, heart rate and sigma R-R declined, while the CR oscillation pattern remained basically unchanged, suggesting a rigidity of the central adaptation mechanisms.

[Analysis of the cardiointervalograms of neurosurgical patients in the postoperative period]. / Analiz kardiointervalogramm u neirokhirurgicheskikh bol'nykh v posleoperatsionnom periode.

The 24-hour dynamics of the oscillatory components of the heart rhythm in neurosurgical patients in the postoperative period is shown. The peculiarities of the wave structure of the spectrum density graph depending on the localization of the pathological process and the severity of the postoperative course were revealed.

[Mathematical model of the sinus rhythm of the heart]. / Issledovanie matematicheskoi modeli sinusovogo ritma serdtsa.

As a result of mathematical simulation a group of signs was formed necessary and sufficient for the description of the oscillatory structure of the cardiac sinus rhythm at the quasi-stationary sections of the recording. The practical employment of the "adjustable" model permits one to obtain the present statistical accuracy of the assessment of signs with a lesser amount of baseline data. A procedure for the automatic measurement of signs by a mini-computer has been elaborated.