[Ambulatory surgery of inguinal hernias].

415 patients with inguinal hernia were operated on in the period of 1996-2005yy. In 87 cases the abdominal wall reconstruction was performed using local tissues, Lichtenstein's method was employed in 139 patients and in 189 cases we performed the modificated combined reconstruction. The latter constitutes of the posterior inguinal wall reconstruction, using local tissues and mesh implantation to the medial part of the inguinal space. Postoperative complications after the combined reconstruction were registered in 12,7%, whereas after Lichtenstein and autoplasty 23 and 30% of patients, respectively, suffered from complications. The low seroma and genital edema incidence in patients where the combined inguinal reconstruction was used, are obviously due to the smaller size of the mesh, low traumatism of the operation and absence of tissue strain and spermatic cord compression. Follow-up results are better in the third group. Pain and <> are registered half more rare then in other groups. There were no hernia recurrence registered in the third group during the 6 years follow-up period.

Electrospray ionization tandem mass spectrometry of 3-[4-bis-N,N-(2- chloroethyl)aminophenyl]acetates of estrane series.

Collision-induced fragmentation of the [M + Na]+ and [M + H]+ ions generated from 3-[4-bis-N,N-(2-chloroethyl)aminophenyl]acetates in the estrane series under electrospray/ionization was studied. Some regularities in fragmentation pathways depending on the nature of functional groups were established. Formation of the [(M + Na) NaCl]+ ions along with [(M + Na) HCl]+ ions from the [M + Na]+ ions was explained using quantum chemical calculations for some simplified models.

The effect of the chain length of polynucleotides on their binding with platinum complexes.

The effect of the length of polynucleotides on their binding with platinum complexes was studied. The highest reaction rate was observed in the reaction with guanosine-containing polynucleotides, whereas cytidine- and adenosine-containing polynucleotides were much less efficient. The monoaqua-forms of the platinum complexes exhibited the highest reactivity in the interaction with polynucleotides in solution. The mechanism implies the formation of the monodentate complex at the first stage which is transformed into the corresponding bidentate complex of chelate type at the second stage. Increase in the length of the polynucleotide chain was shown to enhance its interaction with the platinum complexes.

[The extent of bone resection in osteomyelitis of the chest wall]. / Ob''em rezektsii kostei pri osteomielite grudnoi stenki.

The experience in treatment of 40 patients with osteomyelitis and chondritis of the bones of thoracic wall is presented. 39 patients (of 40) underwent surgery with due regard to an adequate extent of resection within so-called borders of intact tissues. Critical analysis of literature and authors' own experience made it possible to establish strict borders of resection of damaged bones in this disease of thoracic wall frame and to obtain good results of combined treatment in patients over 50 years. Complete removal of chondral tissues and resection of bones within the area of probably normal anatomic formation of the bone, irrespective of the origin of osteomyelitis and chondritis (hematogenous, exogenous), have promoted recovery of the patients. There were no relapses during 1-7 year period.

[Prognosis and prevention of postoperative suppurative-septic complications of hematogenic osteomyelitis]. / Prognozirovanie i profilaktika posleoperatsionnykh gnoino-septicheskikh oslozhnenii gematogennogo osteomielita.

The article deals with experience in the treatment of 295 patients with hematogenous osteomyelitis, who accounted for 51.4% of adult patients with various forms of osteomyelitis. In 15.4% the acute stage of the disease was complicated by sepsis. A recurrence in chronic disease was encountered in 42% of cases. In view of this, postoperative pyoseptic complications were analysed and the main ways for their reduction defined. Early opening of the medullary canal in patients with acute hematogenous osteomyelitis and expansion of the scope of resection in chronic forms have a favourable effect on the prognosis of the disease. Recovery was registered in 74.2% of cases after sequestrnecrectomy and in 94.6% of cases after tubular bone recanalization. Thus, patients with hematogenous osteomyelitis must be treated at specialized departments with early hospitalization if acute hematogenous osteomyelitis is suspected. Operation, ranging from sequestrnecretomy to possible bone extirpation, is still the preferred method in chronic forms of the disease.

[Osteoplastic trepanation and recanalization of the tubular bone in chronic osteomyelitis of the femur]. / Kostno-plasticheskaia trepanatsiia i rekanalizatsiia trubchatoi kosti pri khronicheskom osteomielite bedra.

A new method for the treatment of chronic osteomyelitis of tubular bones is described, realized via osteoplastic trepanation when the disease is localized in the femoral bone. Satisfactory results were achieved in the treatment of 15 patients, remote results were followed for up to 2 years in 13 patients--no recurrences were recorded.