[Dystrophic calcification of the parotid salivary glands in Sjogren's disease]. / Distroficheskaya kal'tsifikatsiya okoloushnykh slyunnykh zhelez pri bolezni Shegrena.

This article discusses a rare clinical case of differential diagnosis between salivary stone disease and calcinosis, which developed against the background of autoimmune pathology. Diagnosis of these pathologies causes difficulties for practitioners, and treatment methods have fundamental differences. In this regard, the description of this case is relevant and significant. The algorithm of the main and additional research methods to confirm the diagnosis is described.

[Ductoplasty of the post-traumatic stricture of a parotid duct]. / Duktoplastika posttravmaticheskoi striktury protoka okoloushnoi slyunnoi zhelezy.

A report on the primary application of the modern technique of plastic removal of stricture of the Stenonic duct. A clinical case of surgical intervention in the localization of stricture and salivary stone is considered. The analysis of the patient's medical history, ultrasound diagnostics, multispiral computed tomography of the maxillofacial region was carried out. Based on the results of the examination, the choice of the surgical intervention technique was made.

Influence of the cumulative effect of zoledronic acid on periodontal microcirculation in rats.

PURPOSE: To evaluate the effect of repeated administration of zoledronic acid (ZA) on the development and severity of osteonecrosis of the jaws. METHODS: In the experiment, 36 rats were used, which were divided into 4 groups: group 1 was injected with saline for 6 weeks, group 2 was injected with ZA once, group 3 was injected zoledronic acid for 3 weeks once a week, group 4 was injected with ZA for 6 weeks once a week. While taking medications, the tooth was removed. The volumetric blood flow rate was studied using laser and high-frequency ultrasound Doppler in the area of the periodontium of an extracted tooth in rats with the application of acetylcholine. Bone tissue was examined out using CBCT. RESULTS: In group 2, there was a violation of blood flow in the mucous membrane, bone microcirculation, but no reliable data was obtained in the bone defect in comparison with group 1. In groups 3 and 4, there was significantly disrupted blood flow. This led to an increase of the osteonecrosis (maximum at the 4th group), which was confirmed by data obtained using CBCT. An inverse relationship was observed between the blood flow of bone tissue and the size of the defect after tooth extraction. CONCLUSION: The introduction of ZA in a dose-dependent fashion resulted in impaired endothelial vasodilation and impaired blood flow to extraction sockets. These findings might explain the development of osteonecrosis of the mandible following removal of a first molar.

Disorders of microcirculation in the mechanism of bisphosphonate osteonecrosis: preliminary study in rats.

We investigated the possibilities of angioprotection and the reduction of osteonecrosis in rats that had been given bisphosphonates. In our experiment, 27 rats were divided into three groups: Group 1 was injected with saline; Group 2 was given zoledronic acid for six weeks; and Group 3 was given zoledronic acid for six weeks, with added doses of sulodexide after three weeks. After that we constructed a model of how the teeth should be extracted. The velocity of linear blood flow in the periodontal area of an extracted tooth in rats was studied using laser and high-frequency Doppler ultrasound (with the application of the vasoactive substance acetylcholine 3% for 1min). We evaluated changes in the structure of the bony tissues of the head using computed tomography, comparing the control group with the saline group. A rapid reduction in microcirculation was detected during the use of zoledronic acid for six weeks. A smaller reduction in microcirculation was detected after three weeks of treatment with sulodexide and zoledronic acid. There was a reduction in blood flow in the mucous membranes and, to a greater extent, in bony tissue. Zoledronic acid causes significant impairment of the periosteal blood flow to the mucous membranes because of a complex of disorders, which includes both the cellular component (impaired endothelium-dependent vasodilation of the mucous membrane vessels) and by reducing the intensity of microcirculation in the mucous membranes and bony tissues. Sulodexide, however, improves the restoration of blood flow and reduces the severity of osteonecrosis.

[Heerfordt-Waldenström disease. Report of two clinical cases]. / Diagnostika sindroma Kheerfordta-Val'denstrema. Dva klinicheskikh sluchaia.

The article presents two clinical cases of patients with Heerfordt-Waldenström disease demonstrating diagnostic difficulties and the need for holistic treatment approach.

[Comparative biomechanical study of surgically assisted rapid palatal expansion with tooth-borne and bone-borne expanders]. / Sravnenie biomekhaniki khirurgicheski assotsiirovannogo rasshireniia neba pri ispol'zovanii distraktsionnykh apparatov s nazubnym i nakostnym tipami fiksatsii.

The study objective was to compare the biomechanics of surgically assisted rapid palatal expansion (SARPE) with tooth-borne and bone-borne expanders. Materials include a sample of 54 cone-beam CT of 27 patients who underwent SARPE (bone-borne, n=21; tooth-borne, n=6) before treatment and at expander removal. Expansion efficacy was estimated by interapecal and intercoronal distances between maxillary canines, premolars and first molars as well as Coronal-Apical Index (CAI = coronal expansion (mm)/apical expansion (mm)). CAI varied between 1.5 and 2.0 in the group of patients with bone-borne appliances, and from 2.3 to 2.6 in the tooth-borne appliances group. The maximal amount of vestibular coronal declination was revealed in premolars by the use of tooth-borne appliances. Bone-borne appliances allowed lateralization of maxilla and the most prominent effect of tooth shift in a vestibular direction, which may be seen as the most important factors in a relapse prevention.

Role of C-reactive protein concentration of blood plasma in assessment of the severity and the effectiveness of treatment in patients with squamous cell carcinoma of the oral cavity mucosa.

The purpose of this study was to determine the prognostic significance of dynamics of C-reactive protein concentration in blood plasma as a marker for the progression of squamous cell carcinoma of the oral cavity mucosa. From January 2014 to August 2014 there were under the observation 35 patients with squamous cell carcinoma of the oral cavity mucosa. All patients were divided into 2 groups: group 1 - primary patients who had been diagnosed with malignant lesions of the oral cavity mucosa for the first time (17 people); group 2 - patients with recurrent disease (18 people). All 17 patients of group 1 received induction polychemotherapy by PF scheme and 18 patients of group 2 - curative polychemotherapy by the following schemes: PF, DCF, TC. In all patients there was performed an assessment of the level of C-reactive protein in blood serum at the stage prior to drug treatment and before each subsequent cycle of chemotherapy. An assessment of the level of C-reactive protein before treatment showed that in 17 patients of group 1 its level was in the normal range. Patients of group 2 had an increased concentration of C-reactive protein in blood plasma. Analysis of obtained data allows concluding that the level of C-reactive protein may be effectively used as a prognostic marker in patients with this pathology.

[Experimental substantiation of hormone replacing therapy by estrogens in treatment and prevention of inflammatory infectious diseases of maxillo-facial region].

Estrogen play the important role in normal current of inflammatory process. At age oppression of synthesis or at surgical menopause in an organism it is formed estrogen-deficiency syndrome shown in particular, in salivary glands change, loss of a jaw bones, disseminated current of inflammatory processes. For study of hormone replacing estrogen's therapy role in experiment, we determine the influence of transdermal estrogen-consisting systems on structure and function of large salivary glands, density of a bone jaws and current of infectious-inflammatory process in laboratory animals. For hormone-replacing estrogen-therapy we used an equivalent doze of estrogen-consisting plaster with a doze of estradiol 0.32 mg per day. The plaster pasted once a week on the ear. Criteria of efficiency were: calculation of bone destruction areas, pathology study of glandulars parotid and densitometries. The received experimental data testify to efficiency of application hormone-replacing estrogen's therapy in inflammatory diseases of maxillofacial area proceeding on a background of estrogen-deficiency.