RESUMEN
Femtosecond inscription of fiber Bragg gratings (FBGs) in each core of a cladding-pumped seven-core Yb-doped fiber enables efficient (≈70%) 1064-nm lasing in a robust all-fiber scheme with ≈33â W power, nearly the same for uncoupled and coupled cores. However, the output spectrum is quite different: without coupling, seven individual lines corresponding to the in-core FBG reflection spectra sum up into a broad (0.22â nm) total spectrum, whereas the multiline spectrum collapses into a single narrow line at strong coupling. The developed model shows that the coupled-core laser generates coherent superposition of supermodes at the wavelength corresponding to the geometric mean of the individual FBG spectra, whereas the generated laser line broadens, with a power (0.04-0.12â nm) like the single-core mode of a seven-times larger effective area.
RESUMEN
All-fiber Raman lasers have demonstrated their potential for efficient conversion of highly multimode pump beams into high-quality Stokes beams. However, the modal content of these beams has not yet been investigated. In this work, based on a mode decomposition technique, we are able to reveal the details of intermodal interactions in the different operation regimes of continuous wave multimode graded-index fiber Raman lasers. We observed that, above the laser threshold, the residual pump beam is strongly depleted in its transverse modes with principal quantum number below 10. However, the generated Stokes signal beam mainly consists of the fundamental mode, but higher-order modes are also present, albeit with exponentially decreasing population.
RESUMEN
We develop a comprehensive theory for describing the experimental beam profiles from multimode fiber Raman lasers. We take into account the presence of random linear mode coupling, Kerr beam self-cleaning and intra-cavity spatial filtering. All of these factors play a decisive role in shaping the Stokes beam, which has a predominant fundamental mode content. Although the highly multimode pump beam is strongly depleted, it remains almost insensitive to the different physical effects. As a result, the intensity of the output Stokes beam is an order of magnitude higher than the pump intensity at its maximum, in quantitative agreement with the experimental results and in contrast with the simplified balance model.
RESUMEN
Multimode fibres provide a promising platform for boosting the capacity of fibre links and the output power of fibre lasers. The complex spatiotemporal dynamics of multimode beams may be controlled in spatial and temporal domains via the interplay of nonlinear, dispersive and dissipative effects. Raman nonlinearity induces beam cleanup in long graded-index fibres within a laser cavity, even for CW Stokes beams pumped by highly-multimode laser diodes (LDs). This leads to a breakthrough approach for wavelength-agile high-power lasers. However, current understanding of Raman beam cleanup is restricted to a small-signal gain regime, being not applicable to describing realistic laser operation. We solved this challenge by experimentally and theoretically studying pump-to-Stokes beam conversion in a graded-index fibre cavity. We show that random mode coupling, intracavity filtering and Kerr self-cleaning all play a decisive role for the spatio-spectral control of CW Stokes beams. Whereas the depleted LD pump radiation remains insensitive to them.
RESUMEN
The power scaling on all-fiberized Raman fiber oscillator with brightness enhancement (BE) based on multimode graded-index (GRIN) fiber is demonstrated. Thanks to beam cleanup of GRIN fiber itself and single-mode selection properties of the fiber Bragg gratings inscribed in the center of GRIN fiber, the efficient BE is realized. For the laser cavity with single OC FBG, continuous-wave power of 334 W with an M2 value of 2.8 and BE value of 5.6 were obtained at a wavelength of 1120 nm with an optical-to-optical efficiency of 49.6%. Furthermore, the cavity reflectivity is increased by employing two OC FBGs to scale the output power up to 443 W, while the corresponding M2 is 3.5 with BE of 4.2. To our best knowledge, it is the highest power in Raman oscillator based on GRIN fiber.
RESUMEN
A brightness-enhanced random Raman fiber laser (RRFL) with maximum power of 306 W at 1120 nm is demonstrated. A half-open cavity is built based on a graded-index (GRIN) passive fiber and single high-reflective fiber Bragg grating written in it directly. Due to the beam cleanup effect in the GRIN fiber enhanced in the half-open RRFL cavity, the output beam quality factor M2 is improved from 9.15 (pump) to 1.76-2.35 (Stokes) depending on power, while the pump-Stokes brightness enhancement (BE) factor increases proportionally to output power reaching 6.1 at maximum. To the best of our knowledge, this is the highest power GRIN RRFL with BE.
RESUMEN
Raman lasing in a graded-index fiber (GIF) attracts now great deal of attention due to the opportunity to convert high-power multimode laser diode radiation into the Stokes wave with beam quality improvement based on the Raman clean-up effect. Here we report on the cascaded Raman generation of the 2nd Stokes order in the 1.1-km long GIF with 100-µm core directly pumped by 915-nm diodes. In the studied all-fiber scheme, the 1st Stokes order is generated at 950-954 nm in a linear cavity formed at GIF ends by two fiber Bragg gratings (FBGs) securing beam quality improvement from M2 ≈ 30 to M2 ≈ 2.3 due to special transverse structure of FBGs. The 2nd Stokes wave is generated either in linear (two FBGs) or half-open (one FBG) cavity with random distributed feedback via Rayleigh backscattering. Their comparison shows that the random lasing provides better beam quality and higher slope efficiency. Nearly diffraction limited beam (M2 ≈ 1.6) with power up to 27 W at maximum gain (996 nm), and 17 W at the detuned wavelength of 978 nm has been obtained, thus demonstrating that the 2nd-order random lasing in diode-pumped GIF with FBGs provides high-efficiency high-quality beam generation in a broad wavelength range within the Raman gain spectral profile.
RESUMEN
Replication proteinâ A (RPA) is an essential single-stranded DNA (ssDNA)-binding protein that initiates the DNA damage response pathway through protein-protein interactions (PPIs) mediated by its 70N domain. The identification and use of chemical probes that can specifically disrupt these interactions is important for validating RPA as a cancer target. A high-throughput screen (HTS) to identify new chemical entities was conducted, and 90 hit compounds were identified. From these initial hits, an anthranilic acid based series was optimized by using a structure-guided iterative medicinal chemistry approach to yield a cell-penetrant compound that binds to RPA70N with an affinity of 812â nm. This compound, 2-(3- (N-(3,4-dichlorophenyl)sulfamoyl)-4-methylbenzamido)benzoic acid (20 c), is capable of inhibiting PPIs mediated by this domain.
Asunto(s)
Proteína de Replicación A/antagonistas & inhibidores , ortoaminobenzoatos/química , ortoaminobenzoatos/farmacología , Anisotropía , Relación Dosis-Respuesta a Droga , Polarización de Fluorescencia , Ensayos Analíticos de Alto Rendimiento , Modelos Moleculares , Estructura Molecular , Relación Estructura-Actividad , ortoaminobenzoatos/síntesis químicaRESUMEN
Various 2-substituted indolizines can be directly and selectively lithiated in the 5 position and subsequent reactions with different electrophiles lead to some novel classes of indolizines. In particular, previously unknown 5-formyl- and 5-iodoindolizine have been prepared by this way and the molecular structure of 5-formyl-2- phenylindolizine was confirmed by X-Ray analysis. The reactivity of the 5-CHO- and 5- COPh groups toward some nucleophiles has been examined, and some additional classes of derivatives (oximes and alcohols) have been obtained. The possibility of Suzuki cross- coupling of 5-iodoindolizines and boronic acids was proven.
