RESUMEN
We are presenting the case of a 53-year-old woman with a history of Sjögren syndrome and a secondary antiphospholipid syndrome admitted at the Nephrology department for the evaluation of renal failure. The patient was initially diagnosed with tubulointerstitial nephritis and subsequently a membranoproliferative type I glomerulonephritis, secondary to cryoglobulins during the course of the disease. Repeated renal biopsies were required to confirm the diagnosis.
Asunto(s)
Riñón/fisiopatología , Insuficiencia Renal/etiología , Síndrome de Sjögren/diagnóstico , Biopsia/métodos , Femenino , Glomerulonefritis Membranoproliferativa/diagnóstico , Humanos , Persona de Mediana Edad , Nefritis Intersticial/diagnóstico , Síndrome de Sjögren/patologíaRESUMEN
We report a case of a 64-year-old man who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anaemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease. LEARNING POINTS: Drug-induced TTP is a rare condition and difficult to diagnose.Decreased activity of ADAMTS13, unusual in drug-induced TTP, was present in this case.
