RESUMEN
Interferon-inducible transmembrane protein 3 (IFITM3) participates in the defense against viral infections. This study identified and compared the frequency of the IFITM3 rs12252 polymorphism in 410 individuals in western Mexico. The western Mexican allelic frequencies (frequency of the "C" allele = 0.18) differ from some American, East Asian and European populations.
Asunto(s)
Alelos , Etnicidad/genética , Proteínas de la Membrana/genética , Polimorfismo de Nucleótido Simple , Proteínas de Unión al ARN/genética , Adolescente , Adulto , Frecuencia de los Genes , Predisposición Genética a la Enfermedad , Genotipo , Voluntarios Sanos , Humanos , México , Persona de Mediana Edad , Adulto JovenRESUMEN
Idiopathic recurrent pregnancy loss (IRPL) is defined by three or more consecutive miscarriages occurring before the twentieth week of gestation as a result of unidentified etiological factors. The results of previous studies have indicated that prothrombotic factors play a pathogenic role in early and late pregnancy. This study aimed to identify inherited prothrombotic and hypofibrinolytic risk factors in Mexican-Mestizo patients with IRPL. Fifty-six women with IRPL and 50 control women with at least two full-term pregnancies and no history of RPL were included in this case-control study. Four prothrombotic (F5 G1691A, F2 G20210A, MTHFR C677T-A1298C) and one hypofibrinolytic (PAI1 4G/5G) restricted fragment length polymorphisms were subjected to molecular analysis. In the case of hypofibrinolytic ACE Ins/Del (I/D), identification was performed by direct PCR. The independent risk correlated with the presence of polymorphisms in IRPL patients was estimated using odds ratio (OR) with a 95% confidence interval (CI). MTHFR 677TT was the most frequent prothrombotic factor in the IRPL group (23%), followed by the compound-heterozygous C677T-A1298C (16%) and heterozygous F2 20210GA (3.6%). The heterozygous ACE I/D (62%) was the main hypofibrinolytic risk factor of IRPL, followed by the homozygote PAI1 4G/4G (18%). The ACE I/D polymorphism was the only significantly different factor among the cases and controls. The dominant genetic model D/D+I/D vs I/I showed an OR (95%CI) of 2.89 (1.22-6.89) and P = 0.019 in Mexican-Mestizo women. The results of this study support an association between the ACE I/D polymorphism and IRPL risk in a Mexican population.
Asunto(s)
Aborto Habitual/genética , Trombofilia/genética , Estudios de Casos y Controles , Demografía , Femenino , Fibrinólisis , Humanos , México , EmbarazoAsunto(s)
Hemofilia B/sangre , Hemorragia/etiología , Protrombina/análisis , Adulto , Factor V/genética , Humanos , Masculino , Fenotipo , Polimorfismo Genético , Protrombina/genética , HermanosRESUMEN
PIP: A retrospective analysis of the ways that various disciplines have taken to the study of demographic aging is presented. The author concludes by considering gerontology as a science and as the point of convergence for the various disciplines concerned with demographic aging. (SUMMARY IN ENG)^ieng
