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1.
Mech Dev ; 94(1-2): 95-109, 2000 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-10842062

RESUMEN

We have studied several cell behaviour parameters of mutant alleles of fat (ft) in Drosophila imaginal wing disc development. Mutant imaginal discs continue growing in larvae delayed in pupariation and can reach sizes of several times those of wild-type. Their growth is, however, basically allometric. Homozygous ft cells grow faster than their twin cells in clones and generate larger territories, albeit delimited by normal clonal restrictions. Moreover, ft cells in clones tend to grow towards wing proximal regions. These behaviours can be related with failures in cell adhesiveness and cell recognition. Double mutant combinations with alleles of other genes, e.g. of the Epidermal growth factor receptor (DER) pathway, modify ft clonal phenotypes, indicating that adhesiveness is modulated by intercellular signalling. Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway.


Asunto(s)
Drosophila/genética , Proteínas de la Membrana/genética , Alas de Animales/crecimiento & desarrollo , Alas de Animales/patología , Alelos , Animales , Cadherinas/genética , Cadherinas/metabolismo , Diferenciación Celular/genética , División Celular/genética , Drosophila/crecimiento & desarrollo , Receptores ErbB/metabolismo , Regulación del Desarrollo de la Expresión Génica , Hiperplasia , Larva , Proteínas de la Membrana/metabolismo , Mosaicismo , Mutación , Regeneración , Transducción de Señal
2.
Mol Gen Genet ; 257(2): 103-12, 1998 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-9491068

RESUMEN

We have carried out screens for lethal mutations on the second chromosome of Drosophila melanogaster that are associated with abnormal imaginal disc morphologies, particularly in the wing disc. From a collection of 164 P element-induced mutations with a late larva/pupa lethal phase we have identified 56 new loci whose gene products are required for normal wing disc development and for normal morphology of other larval organs. Genetic mosaics of these 56 mutant lines show clonal mutant phenotypes for 23 cell-viable mutations. These phenotypes result from altered cell parameters. Causal relationships between disc and clonal phenotypes are discussed.


Asunto(s)
Elementos Transponibles de ADN/genética , Drosophila melanogaster/genética , Genes de Insecto , Genes Letales , Alas de Animales/crecimiento & desarrollo , Animales , Mapeo Cromosómico , Células Clonales , Drosophila melanogaster/crecimiento & desarrollo , Células Epiteliales/patología , Regulación del Desarrollo de la Expresión Génica , Larva , Morfogénesis/genética , Mosaicismo , Mutagénesis Insercional , Fenotipo , Pupa , Alas de Animales/anomalías
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