[Advanced prostate cancer in Senegal. Clinical aspects at the General Hospital of Grand Yoff]. / Cancer avancé de la prostate au Sénégal. Aspects diagnostiques à l'hôpital de Grand Yoff.

UNLABELLED: Prostate cancer is a common disease, which continues to be discovered at advanced stages in Africa, despite improved diagnostic tools. AIM: The authors report the experience of the Department of Urology, General Hospital of Grand Yoff Dakar in the diagnostic of advanced prostate cancer. MATERIAL: This was a retrospective descriptive study on patients followed for advanced prostate cancer during the period from January 1st, 2004 to May 31st, 2010. RESULTS: There were 102 people aged from 51 to 96 years with an average of 71 ± 9 years. A comorbid condition was associated in 24.5 % of cases. The circumstances of discovery were pain (32 cases), neurological signs (17 cases), and urinary disorders. DRE had objectified an abnormality in all patients. The serum levels of prostate specific antigen ranged from 5.88 ng/mL to 21,660 ng/mL, with an average of 1447.57 ± 812 ng/mL. A prostate biopsy was performed in 44 patients and prostatic adenocarcinoma was found in 97.7 % of cases with Gleason scores greater than 7 (33 cases). We found different metastatic sites at vertebral column (23 cases), at lung (14 cases), and on pelvic bones (11 cases). CONCLUSION: The prostate cancer is a serious condition with high morbidity and mortality. The diagnosis is not made early in developing countries. We need a strategic plan to improve the early screening and we should develop supportive care too because of the high number of advanced cases diagnosed in our context.

[Total cystectomies for cancers locally advanced of bladder about 12 cases in the service of urology of the general hospital of Grand-Yoff]. / Cystectomies totales pour cancers localement avancés de vessie au service d'urologie de l'hôpital général de Grand-Yoff.

OBJECTIVE: The goals of the study is to evaluate the feasability of the total cystectomy for cancer infiltrating locally advanced of bladder and to evaluate perioperatitive morbidity and short-term results. PATIENTS AND METHODS: We made a retrospective study concerning 12 first patients having profited from a total cystectomy for cancer infiltrating of the bladder in our hospital over one period of 1 year. The parameters of study were: the age at the time of the diagnosis, circumstances of the diagnosis, antecedents of the patient, the histological type and stage TNM before and after intervention, the type of derivation associated, duration of the intervention, the anesthesia, complications and morbidity per- and postoperational. We carried out calculations of average and frequency for the data analysis. RESULTS: The mean age was 51 years (extreme: 32; 83). They were nine men and three women. The circumstances of diagnosis were dominated by the total hematuria and in less frequency by the bladder irritative symptoms. The antecedents of the patients were dominated by the schistosomia (five cases) and the tobacco addiction (two cases). The histological type obtained in preoperative after biopsy or trans urethral resection of bladder found, seven cases of squamous cell carcinoma, four cases of transitional cell carcinoma and one case of adenocarcinoma. Into preoperative, three patients were at the stage pT2, eight patients pT3, one pT4. Four patients had a replacement of bladder: three by a bladder in Z and a patient had Camey II. They were the three patients pT2 preoperative and a patient pT3. Two patients had a standard ureterosigmoidostomy type coffey: the patient pT4 and a patient pT3. The six other patients had Bricker. All the patients profited from a blood transfusion peroperational (two units on average). We did not record any operational mortality. The complications and morbidity are represented by the suppurations of wall (three cases), the vesicocutaneous fistula (one case), the infections urinary and the anemia which was constant. CONCLUSION: The management of bladder cancer poses a real problem in our countries because of the diagnosis at advanced stage.

[Urinary incontinence in woman: epidemiologic profile in Sub Saharian countries]. / Incontinence urinaire de la femme: profil épidémiologique au sud du Sahara.

UNLABELLED: The objective of this study was to describe the epidemiologic profile of urinary incontinence of the African woman of three Sub Saharan African countries. MATERIAL AND METHODS: A multicentric study summarized the epidemiological data collected in female from Nouakchott, Dakar and Ndjamena using a questionnaire. All participants filled an anonymous questionnaire including demographic data and marital status, medical, surgical, gynecological and obstetrical history and the characteristics of the urinary incontinence. RESULTS: Overall, 3021 questionnaires were distributed, only 2070 answers (69%) could be processed. Mean age of the overall population was 28 years. Adult women aged less than 30 years accounted for 56% of the study population. The age group 30-49 years accounted for 42% of the population and only 2% of the study group had more than 50 years. The prevalence of incontinence was 367 cases over 2070 (17,7%). The types of incontinence found were: urgency in 28.6% of cases, stress incontinence in 38.4% of cases and mixed in 33% of cases. Approximately 23,9% of nulliparous and 23,5% of the multiparous had urinary incontinence. The leakage was occasional in 75% of the cases and regular in 25% of the cases. According to gravity, in 31% of cases the volume of urines lost necessitated a change of underwear. Of the women presenting urinary incontinence, 85 (23%) consulted a doctor. A psychosocial repercussion was found in 31% of the cases. CONCLUSION: Urinary incontinence is much more frequent in our areas than it was thought to be because it was rarely acknowledged.

L'echographie doppler couleur scrotale dans la recherche etiologique de l'infertilite conjugale

Introduction : l'infertilite masculine est de plus en plus importante(1). Les etiologies sont variees; l'echographie doppler couleur des bourses constitue l'examen d'imagerie de premiere intention dans la recherche etiologique. Le but de notre travail est d'evaluer la place de l'echographie doppler couleur dans l'exploration de l'infertilite masculine. Patients et methodes : Nous avons realise une etude retrospective sur une annee de 53 dossiers de patients ayant consulte pour infertilite du couple. Une echographie doppler couleur des bourses a ete realisee pour tous les patients. Elle a permis de noter pour chaque patient la taille; le volume; les contours du testicule et l'aspect du cordon. Le doppler couleur precisait la cartographie vasculaire. Resultats : la moyenne d'age etait de 39;5 ans; la duree moyenne d'infertilite etait de 07 ans et demi. L'examen clinique avait retrouve 20 cas de varicocele clinique dont 12 gauches et 8 bilaterales. L'echographie Doppler couleur avait retrouve 42 cas de varicocele dont 11 confirmant l'examen clinique (3 varicoceles gauches et 8 varicoceles bilaterales); et 31 infra cliniques avec 13 cas de varicoceles bilaterales; 12 cas de varicoceles droites et 6 cas de varicoceles gauches. Les valeurs du diametre des veines droites et gauches variaient entre 2 et 4;8 mm; un reflux a ete objective chez tous nos patients. 33 patients avaient une atrophie testiculaire droite; 35 patients une atrophie testiculaire gauche. 2 cas de kyste para-epididymaire; 3 cas de micro lithiases testiculaires; deux cas d'hydrocele ont ete retrouves. L'echographie Doppler couleur etait normale chez 3 patients. Conclusion : Cet examen est une methode d'imagerie de premier choix dans la strategie diagnostique de l'infertilite masculine

Varicocele primitive et fertilite : evaluation postoperatoire des parametres du spermogramme et de la fecondite

Objectif : Il n'existe pas de consensus concernant la capacite de la varicocelectomie a ameliorer la fertilite et la fecondite. L'objectif de cette etude retrospective etait d'etudier l'evolution postoperatoire de la fertilite masculine (par les parametres du spermogramme) et celle de la fecondite du couplePatients et methodes: Il s'agit d'une etude retrospective de 50 patients porteurs de varicocele palpable operes selon la technique de Palomo au service d'Urologie de l'Hopital Grand Yoff; Dakar; Senegal. Les parametres etudies sont les parametres du spermogramme (densite; mobilite totale a la premiere heure; vitalite) et du spermocytogramme (taux de spermatozoides de morphologie normale); une fois avant l'operation et a deux reprises apres (entre le 3eme et le 8eme mois et a partir du 9eme mois) et la fecondite postoperatoire du couple chez 35 patients. Resultats : L'etude du spermogramme retrouve; pour l'ensemble des patients; une elevation de la valeur moyenne de tous les parametres; sans normalisation; exception faite de la morphologie (spermocytogramme). L'evolution postoperatoire n'etait statistiquement significative que pour la densite. La majorite des patients (76a 92) presentaient des valeurs du spermogramme preoperatoires inferieures a la normale; excepte pour la morphologie (28) (spermocytogramme). Les parametres du spermogramme se sont ameliores pour 48 a 64des patients selon le parametre etudie. L'amelioration des parametres est d'autant plus importante que leur valeur preoperatoire moyenne etait basse. Les facteurs de bon pronostic postoperatoires sont representes par les patients les plus jeunes (moins de 35 ans) et ceux qui presentaient une varicocele bilaterale; une infertilite de type secondaire et une duree d'infertilite moins longue. Nous n'avons pas etudie la correlation entre le grade de la varicocele et la fecondite. Le taux de grossesse postoperatoire etait de 31;4. Les sujets feconds etaient plus jeunes; avaient une duree moyenne de l'infertilite moins longue et des parametres constamment plus eleves par rapport aux patients infeconds. Les ameliorations postoperatoires de la fertilite et de la fecondite dans cette etude etaient relatives et limitees. Conclusion: Par la frequence de la varicocele et ses consequences sur la fertilite; il s'avere necessaire aussi de mieux et de plus informer les populations sur cette affection; ses consequences et les resultats de son traitement sur la fertilite. De plus une collaboration plus etroite entre gynecologues; biologistes de la reproduction; radiologues et urologues-andrologues permettrait une prise en charge integree de l'infertilite du couple. Il est egalement necessaire; concernant l'infertilite; d'ameliorer la prise en charge psychologique du couple; et notamment celle de la conjointe

Profil clinique du cancer de la prostate au Senegal

Objectives: To describe the clinical features of prostate cancer in Senegal. Materials and Methods: We underwent a descriptive and retrospective study including 121 patients managed for prostate cancer in two hospitals of Dakar between 1997 and 2002. The histological diagnosis was assessed on prostate biopsy or after transurethral resection of the prostate or prostatectomy. We studied: the age of the patients; the PSA level; the stage of the tumor using the TNM staging of 1997; and the circumstances of diagnosis. Results: The mean age was 69 years (52-88); the mean PSA was 72;2 ng /ml (6-578;9). The localized tumors that represented 43;8of the cases were mainly T2 (42;1); while the advanced (T3-T4) tumors represented 41;3of the cases. Metastases were found in 15of cases; and in 78of the cases the metastases could not be assessed. The circumstances of diagnosis were dominated by prostate or cancer-related symptoms which represented 49;6of the cases. The association between symptoms and high PSA was present in 16;5of cases. Conclusion: This study shows an elevated age of our patients correlated with a high PSA level; an advanced tumor stage; an important rate of metastases and the presence of symptoms. Screening is needed for a better management of prostate cancer in Senegal

[Neurologic aspects of vesico-vaginal fistula of obstetrical origin]. / Les aspects neurologiques de la fistule vésico-vaginale d'origine obstétricale.

OBJECTIVE: To study the electromyographic alterations of the urethral sphincter, perineal muscles and lower limbs observed in women with obstetric vesicovaginal fistula. METHODS: We compared a group of 22 women with obstetric vesicovaginal fistula with a control group of 10 women without fistula. Each woman underwent a neurological examination of the perineum and lower limbs and electromyography of the lower limbs and urethral sphincter. According to the classification proposed by MENSAH, the fistulas were classified as simple (54.5%), complex (31.8%) and complicated (13.6%). RESULTS: Twenty women with VVF presented a peripheral nerve lesion. Five of these patients had a clinical and electromyographic lesion; while the other fifteen patients had a subclinical lesion. 68.18% of the fistula patients presented a clinical neuropathy in the perineum. This lesion was detected on electromyography in all patients with fistula. The severity of this denervation lesion ranged from moderate (36.37%) to severe (63.63%). No neurological lesions were detected in the control group. The degree of denervation has more severe in young women (21-25 years) and in primiparous women. In contrast, the severity of denervation did not appear to be related to the history of the fistula. The risk of treatment failure increased proportionally to the severity of denervation. 73% of fistulas with severe denervation remained "unsuturable", or required multiple operations with disappointing results in the form of persistent vesicosphincteric dysfunction. CONCLUSION: Although the psychosocial impairment and upper urinary tract repercussions have been well evaluated, the peripheral neurological lesion has always been underestimated in the management of obstetric vesicovaginal fistulas. The authors consider that the fistula is only the apparent manifestation of "neurovesical damage", which remains the decisive factor in the prognosis and which largely explains the high frequency of treatment failure.