Asunto(s)
Acetilcisteína , Unitiol , Humanos , Acetilcisteína/uso terapéutico , Antídotos/uso terapéutico , CobaltoRESUMEN
Osmium tetroxide is a strong oxidizing agent used in electron microscopy. Eye exposure may cause severe burns, and after inhalation or ingestion damage to the respiratory or gastrointestinal tract occurs. Exposure to osmium and its compounds is extremely rare. We present a case of a 32-year-old female stained by 9 mL of 2% osmium tetroxide in acetone during an accident in the laboratory, with rare dermal and ocular findings. Due to lack of data in toxicological databases and the absence of antidote, the therapy was symptomatic. Osmium was detected in serum 19 hours later (0.22 µg/L) and in urine during the 15-hour collection (three samples-7.05, 1.65 and 8.45 µg/L). In blood serum on admission, after 1 and 2 days after exposure, the levels of iron (28.2, 39.8 and 50.5 µmol/L; reference range 5.8-34.5 µmol/L) and transferrin receptor/ferritine were elevated. To our knowledge, this is the first paper documenting a significant absorption from the skin and potentially from the eye conjunctiva, based on serum and urine analysis. The relationship between increased iron in blood and exposure has not been described yet, and the mechanism remains unknown. The patient is being followed up for the unknown long-term effects.
Asunto(s)
Ojo/efectos de los fármacos , Tetróxido de Osmio/envenenamiento , Piel/efectos de los fármacos , Adulto , Femenino , HumanosRESUMEN
Air quality in the Moravian-Silesian Region and especially in the Ostrava agglomeration represents a very important factor influencing the environment and health of the local population. The area has been burdend for more than two centuries with rapid development of the mining industry and related metallurgical and chemical production. As a result, hundreds of tons of pollutants have progressively been released into the atmosphere. Some of them have been gradually eliminated from the environment; others, such as some heavy metals, remain locally present and burden the local landscape. Ultrafine particles (UFPs; diameter less than 100 nm) are ubiquitous in urban air and an acknowledged risk to human health. Therefore, recurrent situations when statutory limits for airborne dust and selected chemical pollutants are exceeded require more detailed research focused on the sources, paths of propagation, chemical composition and morphology of ultrafine aerosol (UFA). In order to comply with these objectives measurements were carried out directly in production halls and the vicinity of industrial technologies with expected high UFA emission. In line with global trends, focus is increasingly placed on solid aerosols with particle sizes below 1 µm and, where appropriate, on nanoparticles. This is mainly due to a much greater penetration of these particles into an organism and a subsequent initiation of some serious diseases.
Asunto(s)
Aerosoles/análisis , Contaminantes Atmosféricos/análisis , Contaminación del Aire/análisis , Monitoreo del Ambiente/métodos , Tamaño de la Partícula , República Checa , Polvo , Humanos , Industrias , Microscopía Electrónica de Rastreo , Nanopartículas/análisisRESUMEN
Aerosols formed during shooting events were studied with various techniques including the wide range size resolving sampling system Nano-ID(®) Select, followed by inductively coupled plasma mass spectrometry chemical analysis, scanning electron microscopy, and fast mobility particle sizing. The total lead mass aerosol concentration ranged from 2.2 to 72 µg m(-3). It was shown that the mass concentration of the most toxic compound lead is much lower than the total mass concentration. The deposition fraction in various compartments of the respiratory system was calculated using the ICRP lung deposition model. It was found that the deposition fraction in the alveolar range varies by a factor >3 for the various aerosols collected, depending on the aerosol size distribution and total aerosol concentration, demonstrating the importance of size resolved sampling in health risk evaluation. The proportion of the total mass of airborne particles deposited in the respiratory tract varies from 34 to 70%, with a median of 55.9%, suggesting the health risk based upon total mass significantly overestimates the accumulated dose and therefore the health risk. A comparison between conventional and so called 'green' ammunition confirmed significant lowering of concentrations of lead and other toxic metals like antimony in the atmosphere of indoor shooting ranges using 'green' ammunition, although higher concentrations of manganese and boron were measured. These metals are likely to be the constituents of new types of primers. They occur predominantly in the size fraction <250 nm of aerosols.
Asunto(s)
Aerosoles/análisis , Armas de Fuego , Exposición por Inhalación/análisis , Metales Pesados/análisis , Deportes , Contaminantes Ocupacionales del Aire/análisis , Monitoreo del Ambiente/métodos , Intoxicación por Metales Pesados , Humanos , Microscopía Electrónica de Rastreo , Modelos Teóricos , Exposición Profesional/análisis , Tamaño de la Partícula , Intoxicación/prevención & controlRESUMEN
BACKGROUND: Because dacryoliths occur at low frequency, few studies have focused on their composition. We aimed to present findings from morphological, chemical, and mineralogic analysis of 86 dacryoliths. METHODS: We studied 86 dacryoliths obtained during 832 dacryocystorhinostomies (DCR) performed for postsaccal obstruction. We examined the samples with atomic infrared spectrometry (80 samples), amino acid analysis (17 samples), scanning electron microscopy, and an electron microprobe with an energy dispersive detector (seven samples). RESULTS: Dacryoliths were found in 86/832 DCRs (10.3 %), mostly in patients with primary acquired nasolacrimal duct obstruction. All the dacryoliths were soft, composed of organic material, including proteins and mucoproteins, with approximately 20 % amino acid content. There were no "hard" dacryoliths composed of calcium phosphate. The stones were composed of lobes and lobules built on an amorphous core material with small cavities, probably as a result of various chemical processes that produced a gaseous product. The most frequent elements found in inorganic inclusions were silicon, magnesium, sulfur, potassium, calcium, sodium, and chlorine. Also, some particles had high contents of bismuth, titanium, iron, and organic fibers. The fibers found in the core of dacryoliths suggested a potential origin from cotton swabs used in cosmetics. CONCLUSION: Dacryoliths are composed almost exclusively of organic material, including proteins and mucoproteins, with approximately 20 % amino acid content.
Asunto(s)
Cálculos/química , Enfermedades del Aparato Lagrimal/diagnóstico , Litiasis/química , Litiasis/diagnóstico , Conducto Nasolagrimal/patología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Aminoácidos/análisis , Calcio/análisis , Cálculos/ultraestructura , Niño , Preescolar , Dacriocistorrinostomía , Microanálisis por Sonda Electrónica , Femenino , Humanos , Lactante , Enfermedades del Aparato Lagrimal/cirugía , Litiasis/cirugía , Masculino , Microscopía Electrónica de Rastreo , Persona de Mediana Edad , Mucoproteínas/análisis , Espectroscopía Infrarroja por Transformada de Fourier , Adulto JovenRESUMEN
CONTEXT: Cobalt intoxication has become more frequent due to the wide use of metal hip implants. CASE DETAILS: A 56-year-old male patient underwent total hip prosthesis, with a ceramics-on-ceramics implant. Almost 3 years later, it was replaced by metal implant containing cobalt, chromium, and titanium. He developed weight loss, heart, thyroid, and neurological toxicity, with severe hearing loss. He was treated with 2,3-dimercaptopropane-1-sulfonate (DMPS), and cobalt excretion increased. Clinical symptoms apart from deafness gradually resolved. CONCLUSION: We report significant cobalt poisoning from a damaged hip replacement with cobalt containing implant and a slow abrasion of the metal by residual ceramic particles. Chelation therapy resulted in apparent benefit.