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1.
Vopr Virusol ; 54(5): 33-7, 2009.
Artículo en Ruso | MEDLINE | ID: mdl-19882901

RESUMEN

Vitaherpavac, a dry inactivated herpes simplex virus (HSV) culture vaccine, has been obtained, by using the Vero B continuous cell line as a substrate for accumulation of herpes simplex virus types 1 (US strain) and 2 (VN strain). Vitaherpavac and the similar vaccine Herpovax made by the Research Institute of Vaccines and Sera, Saint Petersburg (for which preparation a primary trypsinized chick embryo cell culture used as a substrate for accumulation of HSV types 1 and 2), underwent comparative clinical trials. The tolerability and therapeutic effectiveness of the vaccine were tested in patients diagnosed as having chronic frequently recurring herpes. The trials have yielded positive results that suggest that it is expedient to introduce of the new vaccine Vitaherpavac into practice to treat chronic recurrent herpetic infection of various localizations. Vitaherpavac has been registered in the Russian Federation and permitted for medical application.


Asunto(s)
Vacunas contra el Virus del Herpes Simple/uso terapéutico , Herpes Simple/terapia , Herpesvirus Humano 1/inmunología , Herpesvirus Humano 2/inmunología , Adolescente , Adulto , Animales , Chlorocebus aethiops , Enfermedad Crónica , Vacunas contra el Virus del Herpes Simple/administración & dosificación , Vacunas contra el Virus del Herpes Simple/efectos adversos , Humanos , Inyecciones Intradérmicas , Persona de Mediana Edad , Resultado del Tratamiento , Vacunas de Productos Inactivados/administración & dosificación , Vacunas de Productos Inactivados/efectos adversos , Vacunas de Productos Inactivados/uso terapéutico , Células Vero
2.
Vopr Virusol ; 52(6): 30-6, 2007.
Artículo en Ruso | MEDLINE | ID: mdl-18050715

RESUMEN

The quality of drugs used in the Russian Federation to prevent and diagnose tick-borne encephalitis (TBE) was analyzed. The TBE vaccines made in Russian were shown to be as effective as those manufactured in foreign countries and to have the similar production techniques and quality indices therefore they may be interchangeable in the population's vaccination. The specific activity of has recently increased in terms of the content of TBE virus antibodies. In Russia, a wide range of enzyme immunoassay systems have been designed and manufactured for the detection of human serum (plasma) IgM and IgG antibodies to TVE virus and for that of TBE viral antigen in the biological objects, primarily in the ticks.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/inmunología , Encefalitis Transmitida por Garrapatas/diagnóstico , Encefalitis Transmitida por Garrapatas/terapia , Inmunoglobulinas , Juego de Reactivos para Diagnóstico/normas , Vacunas Virales/normas , Animales , Anticuerpos Antivirales/sangre , Antígenos Virales/sangre , Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación , Encefalitis Transmitida por Garrapatas/sangre , Humanos , Técnicas para Inmunoenzimas/normas , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Ixodes/virología , Control de Calidad , Federación de Rusia , Sensibilidad y Especificidad , Vacunas de Productos Inactivados/inmunología , Vacunas de Productos Inactivados/normas , Vacunas Virales/inmunología
3.
Vopr Virusol ; 41(5): 221-4, 1996.
Artículo en Ruso | MEDLINE | ID: mdl-8967069

RESUMEN

Inactivated culture vaccine against tick-borne encephalitis (TBE) FSME-Immun-Inject produced in Austria ("Immuno") was compared to vaccine produced in the Institute of Poliomyelitis and viral encephalitis by immunological activity, safety, reactogenicity. In mice, no significant differences in protective activity of the vaccines were found when test-strains were diverse strains of TBE virus. Seroconversion in the sera from the vaccinated two times was not significantly different by the level of antibodies determined for both eastern and western serotypes of TBE virus.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/inmunología , Encefalitis Transmitida por Garrapatas/prevención & control , Vacunas de Productos Inactivados , Vacunas Virales , Animales , Anticuerpos Antivirales/análisis , Austria , Encefalitis Transmitida por Garrapatas/inmunología , Pruebas de Inhibición de Hemaglutinación , Técnicas para Inmunoenzimas , Ratones , Ratones Endogámicos BALB C , Federación de Rusia , Vacunación , Vacunas de Productos Inactivados/inmunología , Vacunas Virales/inmunología , Cultivo de Virus
4.
Vopr Virusol ; 40(5): 205-8, 1995.
Artículo en Ruso | MEDLINE | ID: mdl-8659173

RESUMEN

Comparative analysis of the characteristics of tick-borne encephalitis (TBE) strain 205 used for the production of vaccine against TBE and of its variants obtained by passages in mouse brain showed the stability of such properties as infective activity, neurovirulence, sensitivity to physical (heating to 50 C) and chemical (sodium deoxycholate treatment) factors. At the same time increased neurovirulence of variants 205/M10 and 205/M20, which undergone through 10 and 20 passages in white mouse brain, for low-sensitive Syrian hamsters was revealed. Use of a panel of 5 monoclonal antibodies to protein E and of 4 monoclonal antibodies to protein E and of 4 monoclonal antibodies to protein NS3 helped differentiate between not only strains 205 and Sofyin, but between variants of strain 205 as well.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/inmunología , Animales , Encéfalo/virología , Cricetinae , Ácido Desoxicólico/farmacología , Virus de la Encefalitis Transmitidos por Garrapatas/efectos de los fármacos , Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad , Calor , Macaca mulatta , Mesocricetus , Ratones , Ratones Endogámicos BALB C , Ratones Endogámicos C57BL , Pase Seriado , Vacunas Virales , Virulencia
5.
Vopr Virusol ; 28(6): 655-60, 1983.
Artículo en Ruso | MEDLINE | ID: mdl-6670250

RESUMEN

The results of virological and morphological study of the pathogenesis of the infection induced by viruses of the tick-borne encephalitis complex (attenuated TP-21 and E-30 strains) in Syrian hamsters with normal and suppressed immune response are presented. The data obtained indicate long-term persistence of the virus-specific antigen: sufficiently high titres of specific antibodies in the blood serum of the animals at late periods after virus inoculation, positive immunoenzyme tests for virus antigen in the meninges of the hamsters inoculated with the TP-21 strain. Features of the pathogenesis were found to be related to strain characteristics, particularly the degree of their attenuation. Chronic destructive process and reparative gliosclerosis were observed in the CNS of some animals due to Protozoa of the genus Encephalitozoon; in this connection, the necessity of differential diagnosis between cuniculosis and a process of virus genesis is emphasized.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad , Encefalitis Transmitida por Garrapatas/etiología , Animales , Antígenos Virales/análisis , Sistema Nervioso Central/inmunología , Sistema Nervioso Central/patología , Cricetinae , Ciclofosfamida/inmunología , Virus de la Encefalitis Transmitidos por Garrapatas/inmunología , Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación , Encefalitis Transmitida por Garrapatas/inmunología , Encefalitis Transmitida por Garrapatas/patología , Tolerancia Inmunológica/efectos de los fármacos , Mesocricetus , Factores de Tiempo
6.
Vopr Virusol ; 27(3): 311-6, 1982.
Artículo en Ruso | MEDLINE | ID: mdl-7123912

RESUMEN

The paper presents the results of the study of 8 attenuated strains of viruses of the tick-borne encephalitis complex by the marker of pathogenicity for Syrian hamsters in comparison with virulent virus strains. The group of the attenuated strains was found to be nonhomogeneous in this marker of pathogenicity for Syrian hamsters. One of the 8 strains, Pan-114, proved to be highly virulent for these animals by the intracerebral route. The analysis of the experimental results and data from the literature shows the degree of pathogenicity of attenuated strains to differ for mice, Syrian hamsters and monkeys, apparently indicating that each virus variant is attenuated only for a given species of laboratory animals.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad , Animales , Sistema Nervioso Central/patología , Cricetinae , Encefalitis Transmitida por Garrapatas/microbiología , Encefalitis Transmitida por Garrapatas/patología , Mesocricetus , Ratones , Virulencia
7.
Vopr Virusol ; (6): 675-9, 1977.
Artículo en Ruso | MEDLINE | ID: mdl-602146

RESUMEN

Exacerbation of virus infection caused by 4 attenuated strains of viruses of the tick-borne encephalitis complex in BALB/c mice treated with an immunosuppressant was demonstrated. The influence of the treatment was manifested both in an increased extraneural activity of the virus, higher mortality of the experimental animals, and in high virus titers in the brain, liver, and spleen of the immunosuppressed animals, and a decrease or complete absence of specific antibody in their sera.


Asunto(s)
Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad , Terapia de Inmunosupresión , Animales , Anticuerpos Antivirales/biosíntesis , Encefalitis Transmitida por Garrapatas/inmunología , Encefalitis Transmitida por Garrapatas/microbiología , Ratones , Ratones Endogámicos BALB C , Especificidad de la Especie , Virulencia
8.
Vopr Virusol ; (5): 565-8, 1977.
Artículo en Ruso | MEDLINE | ID: mdl-412323

RESUMEN

The evidence of long-term survival of the tick-borne encephalitis complex viruses in primarily trypsinized brain cells of suckling mice inoculated in vivo is presented. The viability of the brain cell cultures from suckling mice inoculated with an attenuated strain was shown to be higher than that of a similar culture of the brain cells from suckling mice infected with a virulent strain. The infectious virus could be recovered for over 200 days of the existence of these cultures. The experimental results appear to be another confirmation of the capacity of viruses of the tick-borne encephalitis complex, particularly of the attenuated strains, for persistence.


Asunto(s)
Encéfalo/citología , Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad , Animales , Células Cultivadas , Haplorrinos , Riñón/citología , Porcinos , Factores de Tiempo , Ensayo de Placa Viral , Virulencia
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