A study of flex miniaturized coils for focal nerve magnetic stimulation.

BACKGROUND: Peripheral magnetic stimulation (PMS) is emerging as a complement to standard electrical stimulation (ES) of the peripheral nervous system (PNS). PMS may stimulate sensory and motor nerve fibers without the discomfort associated with the ES used for standard nerve conduction studies. The PMS coils are the same ones used in transcranial magnetic stimulation (TMS) and lack focality and selectiveness in the stimulation. PURPOSE: This study presents a novel coil for PMS, developed using Flexible technologies, and characterized by reduced dimensions for a precise and controlled targeting of peripheral nerves. METHODS: We performed hybrid electromagnetic (EM) and electrophysiological simulations to study the EM exposure induced by a novel miniaturized coil (or mcoil) in and around the radial nerve of the neuro-functionalized virtual human body model Yoon-Sun, and to estimate the current threshold to induce magnetic stimulation (MS) of the radial nerve. Eleven healthy subjects were studied with the mcoil, which consisted of two 15 mm diameter coils in a figure-of-eight configuration, each with a hundred turns of a 25 µm copper-clad four-layer foil. Sensory nerve action potentials (SNAPs) were measured in each subject using two electrodes and compared with those obtained from standard ES. The SNAPs conduction velocities were estimated as a performance metric. RESULTS: The induced electric field was estimated numerically to peak at a maximum intensity of 39 V/m underneath the mcoil fed by 70 A currents. In such conditions, the electrophysiological simulations suggested that the mcoil elicits SNAPs originating at 7 mm from the center of the mcoil. Furthermore, the numerically estimated latencies and waveforms agreed with those obtained during the PMS experiments on healthy subjects, confirming the ability of the mcoil to stimulate the radial nerve sensory fibers. CONCLUSION: Hybrid EM-electrophysiological simulations assisted the development of a miniaturized coil with a small diameter and a high number of turns using flexible electronics. The numerical dosimetric analysis predicted the threshold current amplitudes required for a suprathreshold peripheral nerve sensory stimulation, which was experimentally confirmed. The developed and now validated computational pipeline will be used to improve the performances (e.g., focality and minimal currents) of new generations of mcoil designs.

Normal categorical perception to syllable-like stimuli in long term and in first episode schizophrenia.

Schizophrenia is associated with deficits in language processing that are evident even at first-episode. However, there is debate as to how early in the processing stream the linguistic deficits appear. We measured categorical processing of artificial syllables that varied in voice-onset time (VOT), and how sensory biasing impacts categorical perception. VOT varied in 5 ms increments from 0 ms (strong /ba/) to 40 ms (strong /pa/). Participants chose whether a syllable sounded more like /ba/ or /pa/. Twenty-two individuals with long-term schizophrenia (Sz) were compared to 21 controls (HCSz), and 17 individuals at their first-episode of schizophrenia (FE) were compared to 19 controls (HCFE). There were three conditions: equiprobable - each syllable had an equal probability of being presented; /ba/-biased - 0 ms VOT (strong /ba/) presented 70% of the time; /pa/-biased - 40 ms VOT (strong /pa/) presented 70% of the time. All groups showed categorical perception and category shifts during biased conditions. Sz and FE were statistically indistinguishable from controls in the point of categorical shift, slope of their response function, and the VOT needed to reliably perceive /pa/. Together, this suggests intact ability to map acoustic stimuli to phonetic categories when based on timing differences in voiced information, both early and late in the disease.

Ultra-focal Magnetic Stimulation Using a µTMS coil: a Computational Study.

A new miniaturized figure-of-eight coil (µCoil) for TMS applications has been developed taking advantage of the Flex circuit technology. First experiments on volunteers demonstrated the ability of the µCoil to elicit sensorial action potentials of the peripheral nervous system. The necessity of reducing the size of standard TMS stimulator arises from the poor spatial resolution of the latter. This study aims to model the µCoil and study the electromagnetic fields induced inside the arm during peripheral nerve stimulation. Results confirmed that the µCoil is capable of inducing a focalized electric field inside the tissues with amplitudes up to 70V/m consistent with the observed peripheral nerve stimulation in healthy volunteers.