RESUMEN
PURPOSE: To study the role of Toxoplasma IgG avidity in evaluating the stage of systemic infection during manifestation as toxoplasma retinochoroiditis and its clinical implications in eastern India. METHODS: Retrospective chart review of Toxoplasma retinochoroiditis cases with Toxoplasma serology for IgG, IgM, and IgG avidity. RESULTS: Included in this study were 17 eyes of 17 patients who had active retinitis located in the macula (14), mid-periphery (2), or periphery (1). They were either primary lesions (12) or reactivations (5). All the cases had Toxoplasma IgG positive; one case had IgM positivity, while all the cases had high IgG avidity values. IgG avidity had a positive correlation with the duration of symptoms. CONCLUSION: We observed high IgG avidity values in active retinochoroiditis in both primary ocular Toxoplasmosis and reactivation subgroups. These results indicate a late ocular manifestation after initial systemic infection with a possible incubation period ranging from 5 weeks to 5 months.
Asunto(s)
Anticuerpos Antiprotozoarios , Coriorretinitis , Inmunoglobulina G , Toxoplasma , Toxoplasmosis Ocular , Humanos , Toxoplasmosis Ocular/inmunología , Toxoplasmosis Ocular/diagnóstico , Toxoplasmosis Ocular/parasitología , Estudios Retrospectivos , Inmunoglobulina G/sangre , Inmunoglobulina G/inmunología , Femenino , Masculino , Toxoplasma/inmunología , Coriorretinitis/parasitología , Coriorretinitis/inmunología , Coriorretinitis/diagnóstico , Adulto , Anticuerpos Antiprotozoarios/sangre , Anticuerpos Antiprotozoarios/inmunología , Adulto Joven , Adolescente , Niño , Infecciones Parasitarias del Ojo/parasitología , Infecciones Parasitarias del Ojo/diagnóstico , Infecciones Parasitarias del Ojo/inmunología , Inmunoglobulina M/sangre , Inmunoglobulina M/inmunología , Persona de Mediana Edad , Afinidad de Anticuerpos , Estudios de SeguimientoRESUMEN
A woman in her 60s presented with vision blur in both eyes, a year post-radiotherapy for oral cancer. The best corrected visual acuity was 20/40 in both eyes. Posterior segment examination was remarkable for a unilateral intervortex venous anastomosis in choroid in her right eye, on the side of her face that had received radiation. Ultra-wide field indocyanine green angiography complimented the clinical findings. We discuss the ramifications of detection of this entity and suggest non-invasive methods of detection.