Asunto(s)
Fármacos Dermatológicos/uso terapéutico , Inmunosupresores/uso terapéutico , Psoriasis/tratamiento farmacológico , Acitretina/uso terapéutico , Adolescente , Niño , Preescolar , Ciclosporina/uso terapéutico , Dapsona/uso terapéutico , Fumaratos/uso terapéutico , Humanos , Metotrexato/uso terapéutico , Pautas de la Práctica en Medicina , Reino UnidoAsunto(s)
Dermatología/normas , Pautas de la Práctica en Medicina/normas , Psoriasis/terapia , Factores Biológicos/uso terapéutico , Niño , Fármacos Dermatológicos/uso terapéutico , Adhesión a Directriz , Humanos , Auditoría Médica , Fototerapia/normas , Guías de Práctica Clínica como Asunto , Psoriasis/diagnóstico , Reino UnidoRESUMEN
This is a synopsis of the main research and clinical findings presented at the 92nd Annual Meeting of the British Association of Dermatologists, held on 3-5 July 2012 in Birmingham, U.K. The conference highlighted the biological, epidemiological and therapeutic advances that have been made recently in the field of dermatology. This synopsis is a selection of the major findings from the meeting; it is not intended to be a substitute for reading the conference proceedings and related references quoted in this article.
Asunto(s)
Dermatología/tendencias , Enfermedades de la Piel/terapia , Humanos , Pediatría/tendencias , Telemedicina/tendencias , Reino UnidoRESUMEN
BACKGROUND: Multiple endocrine neoplasia syndrome type IIA (MEN IIA) has rarely been encountered in pregnancy. CASE: A 22-year-old, nulliparous woman developed bilateral pheochromocytomas during pregnancy. This finding aroused suspicion for MEN IIA, and close endocrinologic follow-up was arranged. Four years later, hyperparathyroidism developed, and the diagnosis was established. The patient underwent prophylactic total thyroidectomy with parathyroid exploration. CONCLUSION: This was the first case of MEN IIA in pregnancy in which the diagnosis was established prior to the development of medullary thyroid cancer, thereby allowing prophylactic thyroidectomy. The presence of bilateral neoplastic disease in young patients may be indicative of a hereditary predisposition to malignancy.
Asunto(s)
Neoplasias de las Glándulas Suprarrenales/diagnóstico , Neoplasia Endocrina Múltiple Tipo 2a/diagnóstico , Neoplasias de las Paratiroides/diagnóstico , Feocromocitoma/diagnóstico , Complicaciones Neoplásicas del Embarazo/diagnóstico , Neoplasias de las Glándulas Suprarrenales/patología , Neoplasias de las Glándulas Suprarrenales/cirugía , Adulto , Diagnóstico Diferencial , Femenino , Humanos , Neoplasia Endocrina Múltiple Tipo 2a/cirugía , Neoplasias de las Paratiroides/cirugía , Paratiroidectomía , Feocromocitoma/patología , Feocromocitoma/cirugía , Embarazo , Complicaciones Neoplásicas del Embarazo/cirugía , TiroidectomíaRESUMEN
The aqueous and methanol extracts of thirty-one herbs traditionally used as anti-fever remedies in China were screened for their in vitro inhibition on human immunodeficiency virus type-1 protease (HIV-1 PR). The activity of recombinant HIV-1 protease was determined by sequence-specific cleavage at the Tyr-Pro bond of the fluorogenic substrate (Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)- Arg) or by HPLC anaylsis of the cleavage products after incubation of the enzyme with a synthetic peptide substrate (Acetyl-Ser-Gln-Asn-Tyr-Pro-Val-Val-amide). Among the herbal extracts examined, the aqueous extracts of Prunella vulgaris and Scutellaria baicalensis and the methanol extracts of Woodwardia unigemmata, Paeonica suffruticosa and Spatholobus suberectus elicited significant inhibition (>90%) at a concentration of 200 microg/ml.
Asunto(s)
Inhibidores de la Proteasa del VIH/farmacología , Proteasa del VIH/metabolismo , Medicina Tradicional China , Fitoterapia , Extractos Vegetales/farmacología , VIH-1/enzimología , Humanos , Cinética , Magnoliopsida , Metanol , Proteínas Recombinantes/antagonistas & inhibidores , AguaRESUMEN
To examine the effect of prenatal steroids on fetal intestinal maturation, eight pregnant rabbits received either dexamethasone (Dex) or saline (Cont) on Days 25-27 of a 31-day gestation. As the rabbit provides a model of growth retardation based on uterine position, fetuses were identified as favored (Fav) or runt (Runt), generating four study groups: ContFav, ContRunt, DexFav, and DexRunt. On Day 31 the small intestinal uptake of glucose and proline was measured by an everted sleeve technique. Additionally, lactase and maltase activity was determined. Small intestinal length and nutrient uptake was significantly increased in the Dex fetuses. Control runts had a trend to decreased levels of nutrient uptake when compared to their favored counterparts. This trend reversed in the Dex fetuses with runt nutrient uptake surpassing that of the favored fetus. A trend to increased enzyme activity of both lactase and maltase was demonstrated. This report provides the first description of maternal steroid administration causing a marked increase in fetal small intestinal length and glucose and proline absorption in an in vivo model of intrauterine growth retardation.
Asunto(s)
Dexametasona/farmacología , Desarrollo Embrionario y Fetal/efectos de los fármacos , Absorción Intestinal/efectos de los fármacos , Intestino Delgado/embriología , Análisis de Varianza , Animales , Dexametasona/uso terapéutico , Disacaridasas/metabolismo , Modelos Animales de Enfermedad , Enterocolitis Seudomembranosa/prevención & control , Femenino , Retardo del Crecimiento Fetal/tratamiento farmacológico , Retardo del Crecimiento Fetal/metabolismo , Madurez de los Órganos Fetales , Glucosa/metabolismo , Intestino Delgado/enzimología , Intercambio Materno-Fetal , Microvellosidades/fisiología , Embarazo , Prolina/metabolismo , ConejosRESUMEN
As fetal swallowing is documented in utero, supplementation of the ingested amniotic fluid with nutrients or hormones has been postulated as a potential prenatal treatment for intrauterine growth retardation (IUGR). To study the effect of epidermal growth factor (EGF) on the developing fetal small intestine, 12 pregnant rabbits underwent operation on day 24 of a normal 31-day gestation. Bilateral ovarian end fetuses underwent catheterization of their respective amniotic cavities with attachment to a miniosmotic pump. Study fetuses received recombinant human EGF at approximately 300 micrograms/kg/d for 1 week; controls received carrier solution only at an equivalent rate. On gestational day 31, fetuses were delivered by cesarean section and somatic measurements were recorded. The small intestine was harvested and proximal, middle, and distal regions were analyzed for lactase and maltase enzyme activity. Additionally, the uptake of radiolabeled glucose and proline was measured by a standard everted mucosal sleeve technique for each segment. Results were analyzed by Student's paired t test and reported as mean +/- SEM. Nine fetal pairs survived (75%). Small intestinal (SI) length was increased in EGF fetuses (54.8 +/- 1.9 cm) versus control (50.4 +/- 2.7 cm) (P = .02). Lactase activity, reported as UE/g protein, was significantly increased in the proximal segments in the EGF-infused fetuses; maltase was significantly increased in both the proximal and middle segments (P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)