¿Está el estrés oxidativo asociado a la gravedad de la enfermedad, a la función pulmonar y al síndrome metabólico en la enfermedad pulmonar obstructiva crónica? / Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

OBJETIVO: Investigar las asociaciones entre los biomarcadores oxidantes/antioxidantes y el estado de gravedad, la función pulmonar y la presencia de síndrome metabólico (SM) en pacientes con EPOC. MÉTODOS: Se incluyeron 74 sujetos, 39 con EPOC (edad 69+/-7 años; mujeres 41%) y 35 para el grupo control (edad 69+/-7 años; mujeres: 43%). Fueron diagnosticados con SM y asignados a uno de los 4 subgrupos: EPOC y control, con y sin SM, respectivamente. Se analizaron los productos de oxidación avanzada de proteína (AOPP), la paraoxonasa-1, la actividad de catalasa, el grupo sulfhidrilo y el hidroperóxido de lípidos totales. La función pulmonar fue analizada por medio de un pletismógrafo. RESULTADOS: El estado de gravedad de la EPOC (GOLD≥3) y la función pulmonar fueron asociados con el grupo sulfhidrilo y AOPP (p≤0,03 para todos). La prevalencia de SM se asoció con AOPP en la EPOC (p = 0,04). Los individuos con EPOC y SM mostraron niveles de AOPP más altos en comparación con los sujetos con EPOC sin SM (p < 0,0001). CONCLUSIÓN: La gravedad de la EPOC, el deterioro de la función pulmonar y la presencia de síndrome metabólico están asociados con el estrés oxidativo en individuos con EPOC

OBJECTIVE: To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD. METHODS: Seventy-four subjects were included, 39 with COPD (age 69+/-7 years; female 41%) and 35 for control group (age 69+/-7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph. RESULTS: COPD severity (GOLD≥3) and pulmonary function were associated with sulfhydryl group and AOPP (P≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (P=.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P<.0001). CONCLUSION: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD

Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease? / ¿Está el estrés oxidativo asociado a la gravedad de la enfermedad, a la función pulmonar y al síndrome metabólico en la enfermedad pulmonar obstructiva crónica?

OBJECTIVE: To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD. METHODS: Seventy-four subjects were included, 39 with COPD (age 69±7 years; female 41%) and 35 for control group (age 69±7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph. RESULTS: COPD severity (GOLD≥3) and pulmonary function were associated with sulfhydryl group and AOPP (P≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (P=.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P<.0001). CONCLUSION: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD.