RESUMEN
Psoriasis is a chronic, inflammatory, T cell-mediated auto-immune disease mainly affecting skin and joints. It is a multisystem disease associated with a multitude of co-morbidities and thus, has become increasingly important for all medical fields, beyond dermatology and rheumatology. Psoriasis has also become more and more important as a model disease for scientist working on chronic inflammation and autoimmunity. And psoriasis has become increasingly relevant as a first-choice disease for proof of concept studies investigating the efficacy of newer pathogenesis-based treatments.
Asunto(s)
Psoriasis , Humanos , Psoriasis/diagnóstico , Psoriasis/etiología , Psoriasis/terapiaRESUMEN
Swiss clinical practice guidelines for skin cancer in organ transplant recipients Transplant patients have increased over the last decades. As a consequence of long-term immunosuppression, skin cancer, in particular squamous cell carcinoma (SCC), has become an important problem. Screening and education of potential organ transplant recipients (OTRs) regarding prevention of sun damage and early recognition of skin cancer are important before transplantation. Once transplanted, OTRs should be seen yearly by a dermatologist to ensure compliance with sun avoidance as well as for treatment of precancerosis and SCC. Early removal is the best treatment for SCC. Reduction of immunosuppression, switch to mTOR inhibitors and chemoprevention with acitretin may reduce the incidence of SCC. The dermatological follow-up of OTRs should be integrated into a comprehensive post-transplant management strategy.