RESUMEN
Pairs of mutually different, spatially overlapping letters were exposed for recognition to groups of patients with Parkinson's disease (PD) and the age-matched control group. Stimulus onset asynchrony (SOA), medical treatment status (de novo vs. treated), and predominant symptoms (tremor vs. hypokinetic rigidity) were an other main variables. The highly significant main effects of SOA and health status demonstrated slowing of elementary visual recognition operations in Parkinson's disease; the results are based on the experimental method that requires neither fast manual responses nor tracking of the display events by saccadic eye movements. Significant interaction between the temporal order of stimulus exposure and health status showed that impairment due to PD was more pronounced for the first stimulus, including the de novo group. Qualitatively similar recognition functions in the binocular and dichoptic conditions showed that the typical pattern of results--prevalence of S2 over S1 at intermediate SOAs--cannot be attributed to retinal processes and should be originating from central processes. An earlier finding (Bachmann, 1994) that PD patients whose nonspecific thalamic nuclei were stimulated intracranially produced qualitatively unusual recognition functions that should have been the result of stimulation, rather than PD as such.
Asunto(s)
Atención , Recuerdo Mental , Enfermedad de Parkinson/diagnóstico , Reconocimiento Visual de Modelos , Enmascaramiento Perceptual , Tiempo de Reacción , Adulto , Anciano , Anciano de 80 o más Años , Antiparkinsonianos/uso terapéutico , Atención/efectos de los fármacos , Percepción de Profundidad/efectos de los fármacos , Dopaminérgicos/uso terapéutico , Femenino , Humanos , Masculino , Recuerdo Mental/efectos de los fármacos , Persona de Mediana Edad , Examen Neurológico/efectos de los fármacos , Pruebas Neuropsicológicas , Enfermedad de Parkinson/psicología , Reconocimiento Visual de Modelos/efectos de los fármacos , Tiempo de Reacción/efectos de los fármacos , Movimientos Sacádicos/efectos de los fármacosRESUMEN
The polygraphic studies with the calculation of the complex of the EEG and REG quantitative parameters which were conducted in 20 individuals of young age and 20 adult individuals, displayed that there was an increase of the vascular tone and a decrease of the brain pulse blood-content which were observed not rarely with the EEG irritation at the same time in the mature age. Papaverine and euphilline action revealed dependence on the initial tone of the brain vessels and expressiveness of the general hemodynamic shifts.
