RESUMEN
For antibody-based drugs, it is important and relevant to study their toxic effects, which can often become limiting when prescribing this type of therapy. General toxicity of antiviral drug Ergoferon based on technologically processed antibodies was studied on sexually mature animals. Analysis of acute toxicity showed the absence of lethal outcomes when the drug was administered to adult rats at the maximum tolerated doses. In a study of repeated dose toxicity, no adverse effects of the drug were detected.
Asunto(s)
Anticuerpos , Antivirales , Ratas , Animales , Antivirales/farmacología , Anticuerpos/farmacología , Pruebas de Toxicidad AgudaRESUMEN
The effects of a new derivative of benzimidazole (K-134) in doses of 5 and 50 mg/kg on the spermatogenesis and fertilizing ability of spermatozoa were studied on male rats. It was found that 2-month course treatment with the studied substance enhances the producing ability of the spermatogenic epithelium and improves fertilizing ability of spermatozoa.
Asunto(s)
Fertilidad/efectos de los fármacos , Quinolinas/farmacología , Epitelio Seminífero/efectos de los fármacos , Urea/análogos & derivados , Animales , Animales no Consanguíneos , Bencimidazoles/farmacología , Citoprotección/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Masculino , Ratas , Epitelio Seminífero/fisiología , Espermatogénesis/efectos de los fármacos , Testículo/efectos de los fármacos , Urea/farmacologíaRESUMEN
The effects of impaza on ovulatory cycles, sexual behavior, and conception processes were studied in female rats. A two-week course of impaza in doses of 3 and 15 ml/kg did not affect alternation of estrous cycle phases, the incidence of estrus reducing. Sexual behavior of these females was characterized by activation of the receptive sexual motivations; conception was characterized by a higher fertility index and a lower fetal mortality.
Asunto(s)
Anticuerpos/farmacología , Ciclo Estral/efectos de los fármacos , Fármacos para la Fertilidad Femenina/farmacología , Fertilización/efectos de los fármacos , Aptitud Genética/efectos de los fármacos , Conducta Sexual Animal/efectos de los fármacos , Animales , Animales no Consanguíneos , Ciclo Estral/fisiología , Femenino , Fertilización/fisiología , Mortalidad Fetal , Aptitud Genética/fisiología , Libido/efectos de los fármacos , Tamaño de la Camada/efectos de los fármacos , Tamaño de la Camada/fisiología , Masculino , Embarazo , Ratas , Conducta Sexual Animal/fisiologíaRESUMEN
The effects of kardostin on the ovulatory cycle, conception, and sexual behavior of female rats have been experimentally studied. It is established that a two-week therapy with kardostin at a dose of 5 and 15 mg/kg changed phases of the estrous cycle (with the estrus phase being most prevalent) and led to ambiguous changes in the sexual behavior of female rats (a dose of 5 mg/kg increased sexual behavior, while a dose of 15 mg/kg inhibited it), activated fertility, and improved the quality of conception.