The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial.

BACKGROUND: Palmitoylethanolamide (PEA) has analgesic/anti-inflammatory properties that may be a suitable alternative to over-the-counter (OTC) non-steroidal analgesics/anti-inflammatories. While OTC pain medications can impair strength training adaptations, the mechanism of action of PEA is distinct from these and it may not negatively affect skeletal muscle adaptations to strength training. METHODS: The primary aim of this study was to investigate the effects of daily PEA supplementation (350 mg Levagen + equivalent to 300 mg PEA) combined with 8-weeks of resistance training on lean body mass with secondary aims addressing strength, power, sleep, and wellbeing compared to placebo (PLA) in young, healthy, active adults. In a randomized, controlled, double-blinded trial, 52 untrained, recreationally active participants aged 18-35 y were allocated to either the PEA or PLA groups. Participants consumed either 2 × 175 mg Levagen + PEA or identically matched maltodextrin capsules during an 8-week period of whole-body resistance training. This trial assessed the pre- to post- changes in total and regional lean body mass, muscular strength (1-RM bench, isometric mid-thigh pull), muscular power [countermovement jump (CMJ), bench throw], pain associated with exercise training, sleep, and wellbeing compared with the PEA or PLA condition. RESULTS: 48 Participants were included in the final intention to treat (ITT) analysis and we also conducted per protocol (PP) analysis (n = 42). There were no significant between-group differences for total or regional lean muscle mass post-intervention. There was a significantly higher jump height (CMJ) at week 10 in the PEA group compared to the PLA (Adjusted mean difference [95% CI] p-value; ITT: - 2.94 cm [- 5.15, - 0.74] p = 0.010; PP: - 2.93 cm [- 5.31, - 0.55] p = 0.017). The PLA group had higher 1-RM bench press post-intervention compared with the PEA group (ITT: 2.24 kg [0.12, 4.37] p = 0.039; PP: 2.73 kg [0.40, 5.06] p = 0.023). No significant treatment effects were noted for any of the other outcomes. CONCLUSION: PEA supplementation, when combined with 8 weeks of strength training, did not impair lean mass gains and it resulted in significantly higher dynamic lower-body power when compared with the PLA condition. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ANZCTR: ACTRN12621001726842p).

Research and Development Prospects for Sugarcane Industry in Vietnam.

Sugarcane is one of the most important industrial crops in Vietnam and covers a total of 127,000 hectares of plantation area. In the season 2020-2021, Vietnam has produced 0.763 million tons of sugar (accounting for 0.34% total world sugar production). A current sugarcane production of 7.498 million tons is being used mainly for sugar production for direct consumption, ethanol production, bio-electricity and fertilization. To ensure crop sustainability, various policies and plans have been implemented. Crop breeding and zoning improvement programme significantly influence sugarcane production and sugar yield. Over 25 years since the programme "one million ton of sugar" was promoted, Vietnam currently possesses 25 sugar mills with a total capacity of 110,000 tons of sugarcane per day. Major problems of sugarcane industry as well as research and development have been discussed in this review. Recent research and development work focused on the added values of co-products to ensure sustainability of the sugarcane industry. Molasses will be used for ethanol production, and bagasse is used as the biomass for the alternative energy. Sugarcane and sugar would be the main feedstocks for those bio-economy growths in Vietnam. To keep the sustainable development of the sugar industry, and to meet the demand of the food and non-food requirements, it is necessary to upgrade the sugar value chain through the adoption and the development of co-products of the sugar industry.

Structure of Investor Networks and Financial Crises.

In this paper, we ask whether the structure of investor networks, estimated using shareholder registration data, is abnormal during a financial crises. We answer this question by analyzing the structure of investor networks through several most prominent global network features. The networks are estimated from data on marketplace transactions of all publicly traded securities executed in the Helsinki Stock Exchange by Finnish stock shareholders between 1995 and 2016. We observe that most of the feature distributions were abnormal during the 2008-2009 financial crisis, with statistical significance. This paper provides evidence that the financial crisis was associated with a structural change in investors' trade time synchronization. This indicates that the way how investors use their private information channels changes depending on the market conditions.

Assessment of stock process in national business during period 1999-2003 (continued No 12-2004)

To the end of 2003, there were 73 national pharmacy businesses conducting capitalization. Of these businesses, there were 8 central national pharmaceutical businesses and 65 local national pharmacy businesses. 33/64 cities and provinces in nationwide was conducted capitalization. Stock process in national business and in national pharmaceutical business was faster than before but had not completed planning. Funds size of business conducting stock was small. In pharmacy, there were 9 businesses having 10 billion of funds conducted stock, acquired 42.9% of national pharmaceutical businesses with 10 billion of funds. After capitalization, the number of business having 100% of government funds was only 4.1%; and business having governable shares belong to government were 6.2%. 11/73 pharmaceutical joint stock companies had production line meeting to GMP standard

Assessment of stock process in national business during period 1999-2003

The reality, some results and shortcomings of privatization process of state owned pharmacies were evaluated at period 1999-2003. The result: privatizating state owned pharmacies is relatively good, the amount of privatizated state owned pharmacies increase continously in past years. However, although there were 54,1% of provinces and cities implementing privatization but mainly that are enterprises belong to 2 regions of The Red river delta and South- East Viet Nam. This showed that the privatization process of regions isn’t equal. According to the plan, in 1998 there had been 7 units carrying out privatization but to the end of the 2000, there was only 1 first unit conversing successtly. That is the branch of Hai Phong 1 Health company changing into HaiPhong Health trade privatization company. Estimating to 12/2003, there were 8 center state owned pharmacies and 65 local state owned pharmacies privatized. They concentrate most in South VietNam

Investigation on drug supply activities in the hospital 19/8 of the Ministry of Public Security

Pharmaceutical Preparations; Medicine; Therapeutics; hospitals; drugs Results of the survey on implementing instruction 30/CT – BYT (Ministry of Health – MOH) of 19/8 Hospital in the period of 1997-2001, showed that: Council of medicine and treatment war established and broadened its activities. The medicine list of 19/8 Hospital is amended and supplemented every year. The rate of essential medicine increases from 64.64% to 67.15%, the rate of domestic drugs also see the rise from 24.5% to 33.8%. However there was a decrease from 75.5% down to 66.2% of imported drugs. The supply of medicine increased annually: 142.9% in 2001 compares to that of 100% in 1997. The rate of antibiotic and vitamin witness the decrease by 14% and 12.7% respectively